Thursday, February 15, 2018 11:53:33 PM
Dr. Alkons research shows how PKCe levels can be measured in the skin, and how the levels directly correlate with the probability of getting AD in the future.
These two articles show how it can be done:
https://www.researchgate.net/publication/263934332_Fibroblast_Aggregation_Rate_Converges_with_Validated_Peripheral_Biomarkers_for_Alzheimer%27s_Disease
https://www.researchgate.net/publication/230657221_Spatiotemporal_Complexity_of_Fibroblast_Networks_Screens_for_Alzheimer%27s_Disease
The abstract for that first one has a particularly interesting part in it:
"Furthermore, we show that by using a simple majority rule, i.e., two out of the three assays have the same outcome, we significantly increase the agreement with clinical AD diagnosis (100%). Based on the high accuracy of this strategy, the biomarker profile appears to accurately identify AD patients for therapeutic intervention."
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