makemydaze Sunday, 02/11/18 04:13:38 PM Re: Penny Double post# 140614 Post # of 238109 Very interesting article Penny and thanks for posting. I'm thinking Harald Hampel is a great source of information and inspiration for Dr Missling. http://www.pharmaceuticaldaily.com/harald-hampel-to-become-anavexs-scientific-advisory-board-member/ Harald appears to be a big believer in Precision Medicine - from one of his research papers: "The emerging paradigm of precision medicine aims at optimizing the effectiveness of disease prevention and therapy, by considering an individual’s specific biological makeup (e.g. genetic, epigenetic, biomarker, phenotypic, lifestyle and psychosocial characteristics) that recognizes and embraces the heterogeneity of disease for targeted interventions aimed at specific biological subsets rather than the traditional concept of neurodegenerative diseases or brain proteinopathies, such as Alzheimer’s disease (AD) as homogenous clinicopathological or clinicobiological entities. Therefore, drug discovery and development in precision medicine starkly contrast with the classical “one-drug-fits-all” approach." and "The objective of precision medicine is to decipher the specific biological and molecular perturbations associated with disease among specific sub-populations. This approach helps understand the final diagnostic dilemma of clinical heterogeneity by identifying a person’s comprehensive and characteristic pattern of risk factors and biological dysfunction, as reflected by genomic and genetic variants, neuroimaging indicators (structural, functional, metabolic) as well as fluid-based biological markers (cerebrospinal fluid [CSF], blood, urine, saliva). By understanding the complexity of these alterations and identifying the importance of specific alterations among groups of patients, a refined preventive or therapeutic approach that is specifically personalized (i.e. “customized”) to the individual can be applied." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363725/ Lucky for us that Missling surrounds himself with great scientists.