Therapeutic Solutions International Inc (TSOI)

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Conclusions

We attempted to examine the possible application of pterostilbene for therapeutic intervention of drug-resistant bacteria. Resveratrol and pterostilbene exhibited antibacterial activity without exerting unacceptable cytotoxicity on mammalian cells.Pterostilbene was more efficient for bacterial eradication than resveratrol. Pterostilbene was able to reduce biofilm formation and kill the MRSA in immune cells by virtue of its strong antibacterial activity and facile delivery across biomembranes. This natural agent also showed a 6-fold higher cutaneous absorption compared to resveratrol. Pterostilbene had unique mechanisms of action different from resveratrol according to proteomic assay. Bacterial membrane disruption and the change of stress-induced protein profiles were the biocidal mechanisms of pterostilbene. This compound is of interest as a feasible antimicrobial candidate for use against MRSA infection in skin tissues.