Edit - I quoted/highlighted the BMRN data..not ONCE. Factor VIII is Hemophilia A, Factor IX is Hemophila B. - sorry for the confusion. Actually it's both... They reference ONCE (George - Hemophilia B)... http://www.nejm.org/doi/10.1056/NEJMoa1708538 and BMRN (Rangarajan - Hemophilia A)... http://www.nejm.org/doi/10.1056/NEJMoa1708483