updated institutional Holders
RA Capital Management LLC 8,435,584 8,435,584 7.130 06/30
venBio Select Advisor LLC 6,632,452 2,694,422 5.606 06/30
Perceptive Advisors LLC 6,010,660 901,852 5.081 06/30
The Vanguard Group Inc. 3,524,160 1,162,232 2.979 06/30
683 Capital Management LLC 3,341,750 51,750 2.825 06/30
Point72 Asset Management LP 3,000,000 3,000,000 2.536 06/30
Renaissance Technologies LLC 2,353,400 (351,000) 1.989 06/30
Sphera Funds Management Ltd. 2,200,000 (700,000) 1.860 06/30
BlackRock Fund Advisors 1,854,246 (111,669) 1.567 06/30
Armistice Capital LLC 1,600,000 (3,200,000) 1.352 06/30
Millennium Management LLC 1,302,800 1,271,569 1.101 06/30
EAM Investors LLC 891,630 891,630 0.754 06/30
Geode Capital Management LLC 599,610 284,457 0.507 06/30
Bridgeway Capital Management 460,964 0 0.390 06/30
Evercore Wealth Management LLC 168,414 0 0.142 06/30
Paloma Partners Management Co. 151,579 (160,562) 0.128 06/30
Essex Investment Management Co 150,620 150,620 0.127 09/30
Northern Trust Investments In 116,283 0 0.098 06/30
Peter B. Cannell & Co. Inc. 109,875 20,500 0.093 06/30
Pura Vida Investments LLC 100,000 100,000 0.085 06/30
Jane Street Capital LLC 82,686 82,686 0.070 06/30
The Bank of New York Mellon Co 67,668 6,509 0.057 06/30
Rehmann Capital Advisory Group 53,000 53,000 0.045 09/30
Fore Research & Management LP 50,000 50,000 0.042 06/30
Victory Capital Management In 45,040 45,040 0.038 09/30
Citadel Advisors LLC 38,718 27,735 0.033 06/30
The California Public Employee 33,400 0 0.028 06/30
Deutsche Asset Management Inve 30,000 30,000 0.025 06/30
Vanguard Fiduciary Trust Co. 27,200 0 0.023 06/30
SSgA Funds Management Inc. 25,375 0 0.021 06/30
Clear Harbor Asset Management 25,000 (75,000) 0.021 09/30
Cubist Systematic Strategies L 23,000 23,000 0.019 06/30
Morgan Stanley & Co. LLC 22,793 22,793 0.019 06/30
Guggenheim Funds Investment Ad 20,502 0 0.017 06/30
Wolverine Trading LLC 15,318 15,318 0.013 06/30
Goldman Sachs & Co. LLC (Priva 13,732 13,732 0.012 06/30
BlackRock Advisors LLC 13,305 0 0.011 06/30
Two Sigma Securities LLC 13,164 13,164 0.011 06/30
Excalibur Management Corp. 11,000 11,000 0.009 09/30
Raymond James Financial Servic 10,250 10,250 0.009 09/30
Elgethun Capital Management I 10,000 0 0.008 06/30
Edge Wealth Management LLC 10,000 0 0.008 09/30
BNY Mellon Capital Markets LLC 6,342 (18,354) 0.005 06/30
Merrill Lynch Pierce Fenner 5,000 0 0.004 06/30
Springbok Capital Management L 3,900 3,900 0.003 06/30
Gemmer Asset Management LLC 1,939 1,681 0.002 09/30
Morgan Stanley Smith Barney LL 1,500 1,000 0.001 06/30
Manulife Asset Management Ltd. 1,032 (158) 0.001 06/30
D.A. Davidson & Co. (Investmen 1,000 0 0.001 06/30
Citigroup Global Markets Inc. 910 910 0.001 06/30
