I only have two things running at start up in Windows 10,
One drive and Defender, I have Malwarebytes start on a 10 second delay, maybe I'm rolling the dice, a little strict?
I right click and disable the item rather than click on and hit the disable button on the bottom right, not sure if this makes a difference, but they stay disabled...until I get an update that is. :(
Also I make a habit of when I install new software I'll go to its options and set it not to run during startup.
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