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Experimental Calithera compound cripples key lung cancer mutations

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Sikmarson   Thursday, 10/05/17 08:49:17 AM
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Post # of 188 
Experimental Calithera compound cripples key lung cancer mutations

...The researchers found that a mutated gene called KEAP1 teams up with another abnormal gene, KRAS, to cause lung cancer cells to grow aggressively. In so doing, they expel one type of glutamate and break down another to make energy. When the scientists tested CB-839 in mouse models of lung adenocarcinomas that had both mutations, the drug stopped the tumor growth....

Link: fiercebiotech

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