NorthWest Biotherapeutics Inc (NWBO)

[GoodGuyBill]

Thanks Sentiment-stocks.

Based on your comments below, NWBO may have an issue meeting its PFS endpoint #s because patients with pseudo-progression (caused by DCVax-l) are deemed to have disease progression (since there is no process within the trial protocol that seeks to distinguish between the two).

If LL was growing aware of it in 2012 when she told her tale of two tumors, then she may have been seeing it by 2011/2012 in the trial. But by then, there was a prior protocol that most likely delineated exactly how progression would be read, and as I went into some detail in post #102956, that there are no words in the April 2013 protocol about "waiting and seeing" and then doing another MRI in a couple of months. There is no baseline MRI AFTER you enter the trial that is written about in the protocol. RK believes that it is being done because MacDonald criteria does this. But that is NOT what is in the protocol. And so, IMO, it really doesn't matter what any other assessment criteria does or doesn't do. It's the protocol that calls the shots here.