Therapeutic Solutions International Inc (TSOI)

[centsability4me]

Link to new Pterostilbene study info :

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=8101&path%5B%5D=23865

Modulation of macrophage polarization and lung cancer cell
stemness by MUC1 and development of a related small-molecule
inhibitor pterostilbene

( TSOI has pterostilbene patents working their way through the process ,and TSI's flagship product- Projuvenol is a pterostilbene formula ,so this study is very relevant )

Here are a few points from this study :

1) Tumor-associated macrophages (TAMs) polarized to the M2 phenotype play key roles in tumor progression in different cancer types, including lung cancer.

2) Pterostilbene may have therapeutic potential for modulating the unfavorable effects of TAMS in lung cancer progression.

3) We found that the treatment of phytochemical pterostilbene led to the suppression of TAM-mediated CSC generation via modulating MUC1 signaling. In conclusion, we have shown that MUC1 was involved in TAM-mediated lung CSC generation ,and agents such as phytochemical pterostilbene that can negatively modulate MUC1 expression could potentially be used to suppress lung CSC generation and CSC-associated malignancy.