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Re: BWIS post# 76369

Monday, 09/26/2016 4:46:45 PM

Monday, September 26, 2016 4:46:45 PM

Post# of 722825
BuyWhenISell,

Let's look at what we do know and what might happen because of it in the simplest possible scenarios. First we know and big pharma knows that DC treatment potentiates checkpoint inhibitors. These pharmas can either look at NWBO or look for other DCs which may or may not work as well as DCVax in their view. If they skip this approach they would need to experiment with other therapies for use in combinations where safety might be more of an issue. DCVax-L is already a good ways through the path to approval and if Direct moves into registrational status, utilizes optimized endpoints and receives an SPA it might be too. The shotgun approach takes a good deal of time and DC therapies close to approval are very few. If they can get their products used 3× more while perhaps using less product with a better safety profile in a relatively short period of time with potentially 2 types of DC treatment vs having a big question mark in front of them for quite a while, what do you think will make the most sense to their shareholders who also have their own experiences with cancer?

Now is the time that pharma has some leverage with NWBO but if Linda plays hardball and we go into extra innings that leverage will be lost if L is approved before they strike a deal. In most cases, pharma would want better validation but they basically already convinced themselves. Hardball could hurt investors in the short run if potential partners balk at Linda's terms but if NWBO begins monetization without a deal the potential partners could lose in a much bigger way. Their worst case scenario would be if NWBO monetizes and the investigstion finds one or more was found to be playing dirty with NWBO. I really hope this is not the case. Best wishes.
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