NorthWest Biotherapeutics Inc (NWBO)

[Chiugray]

Doc, This is very insightful. This is yet another piece of the therapeutic picture that is forming.

For those who still believe that the science will win the day there is proof of this found in one line of the patent regarding combination therapies. From patent # US 2015/0273033 A1, page 5, 1st paragraph "[0048] FIGS. 4 A+B show that tumor lysate-pulsed dendritic cells down regulate expression of PD-L1." What this means is as long as activated DCs remain in the tumor or tumor cavity, regulation of checkpoint molecules is secured. Checkpoint molecules return when these activated DCs leave the site too soon. How do you fix this? Keep the injections at or about 2 weeks or combine treatment with checkpoint inhibitors. Now, why would big pharma want their hands tied like this?

I read that the FBI is working on 3 big fraud cases and that one of them is much bigger than the Bernie Madoff fraud. This was reported by the same person who told the SEC about Bernie way before any investigation was ever done.