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CDEX Director Coates, Paradigm Shifts in Spectroscopic Measurements:

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Viking65   Friday, 07/24/15 11:29:19 PM
Re: None
Post # of 45763 
CDEX Director Coates, Paradigm Shifts in Spectroscopic Measurements: Example…Spectral Sensors

University of Washington


Recipient of the 2013 Pittcon Awards, Dr John Coates

Biophotonics Next-Generation IR Microscopy: The Devil Is in the Detail

CDEX's John Coates, Coates Consulting

One of the most important attributes of infrared spectroscopy is its ability to handle physically small samples or small features on samples. Important applications include forensic analysis of a crime scene, where infinitesimal evidentiary samples are collected for identification and/or characterization. Another consideration is the ability to isolate and characterize cell defects, including the cancerous regions of a biological specimen. In the early days of IR spectroscopy, the issue was how to handle such small samples and how to get sufficient energy to them to enable recording a useful spectrum. The options ranged from using relatively low cost microsampling accessories, such as beam condensers, to specially configured microscope accessories. For more than a decade, the role of the IR microscope has been growing, and dedicated products are available that enable microscopic-scale samples to be handled and characterized on a routine basis. Although these products can be extremely expensive – ranging from approximately $40,000 to $200,000 – they are one of the most valuable and cost-effective tools in the analytical arsenal. More recently, the biggest advances have been in imaging areas, with either mapping stages or imaging arrays, or combinations of both.



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