Xencor Inc (XNCR): XmAb7195 Questions 1. XmAb7195 engage...

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BayAreaBiotechI

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BayAreaBiotechI

Re: None

Friday, 06/06/2014 11:11:44 PM

Friday, June 06, 2014 11:11:44 PM

XmAb7195 Questions

1. XmAb7195 engages the Fc?RIIb on B-cells to dampen IgE production. Bassil said it would take months to see an effect. Why does it take long? Shouldn't the B-cell be shut down immediately?

2. XmAb7195 engages the Fc?RIIb on liver sinusoidal endothelial cells, targeting IgE bound XmAb7195 to the liver for destruction, which was shown nicely by PET imaging in mice. IgG1 is a nice control, but it is not Xolair, like Bassil eluded to, it does not bind IgE. Bassil stated Xolair does not go to the liver, but I don't see any evidence of that, where is the data?

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