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Many doctors doubt optune. They think it doesn't work. "4] Despite earning regulatory approval, the efficacy of this technology remains controversial among medical experts.[1][5]"
https://en.m.wikipedia.org/wiki/Alternating_electric_field_therapy
This is why stock nvcr low. Because people are subjective . They see it passes ph3 after ph3 but decide they don't want to believe. Vb111 is immunotherapy results are seen late this is why not stopped back in August but now if people stay alive they may stop it
There is similarity between optune and vb111 and again it shows how not objective people are including doctors. Optune passed phase 3 it's approved by fda . Trial stopped early and most of all it's obvious it will work in many cancers but look at valuation of nvcr. It's the same here with vblt low valuation because of market stupidity same with optune how stupid people can be is just beyond me. Optune is million times better than avastin
There was conditional approval and now it's just approved but the reason is not the anti cancer but other things it helps like what the write reduction of cortico...
Avastin is like the old generation drugs that just milk the patients money. Optune and vb111 together with more immunotherapy to come is the future
I don't know if this is the reason.
It was very personal there. I think he referred to his own celebration and he will know the results before end q1 maybe more like end of q4 17
The article from bottom to top gives the feeling to the reader of coming celebration that is going to take place in the city modiin like Hanuka miracle and holiday that this city related too. Not only he said it clearly the whole article imply imminent...
The market valuation of vbl is exactly as staccani evaluate it. According to the market cap u can tell clearly that the market consider each word coming from this company as a possible lie exaggeration or hiding the full picture. There is no other reason why a company that passed 3 phase 2 is at such a low valuation other than the market says its word clearly that this company may be a scam
You used translator but I am native Hebrew speaker he said "we will get the fda approval in 2018" there was no condition or option attached to this sentence. He also said the ph3 is over before that sentence and yes he did ask him about his wet dream. About the stock even without this interview it should be at 500 mil market cap by now after the validation from the Japanese but it's not so I wouldn't care much about the stock price
an interview from 22nov with Dr Erez Feige a worker at VBL.
2 interesting things:
1. he says clearly " we get FDA approval in 2018"
2. The phase 3 is over
In hebrew here are the 2 places
1. ?????? ??? ?? ????? ?-FDA ?????????
"???? ?????? 2018 ???? ?????? ??????
2. "????? ??????? ?? ??????? ???? ????? ???? ????, ?????? ??? ??? ?? ???? ???? ????? ???????????, ??? ????? ?? ???????? ?????? ????? ??????? 2018 ????? ?? ?????? ????? ???? ??????? ??? ?? ???? ?????? ?? ????????.
here is the full interview
http://www.mnews.co.il/stories/6932/-%D7%90%D7%A0%D7%97%D7%A0%D7%95-%D7%9C%D7%90-%D7%A8%D7%95%D7%A6%D7%99%D7%9D-%D7%9C%D7%94%D7%99%D7%95%D7%AA-%D7%9B%D7%9E%D7%95--%D7%98%D7%91%D7%A2--
Here u said different thing. Here u said the 8 not shown may be alive
Could it u both right ? At the time they published it at the beginning it was 810 and now it's down to 477 but they didn't updated yet the presentation
I look at the chart and the 9th patient is not alive
Thank u for repeating the explanation from back then. If u look at my comment today to staccani I did mentioned there were replies to his allegations but from some reasons couple of hours ago I couldn't find it. No big deal - we all agree the Japanese deal and the fact trial did not finished by mid October outweighs the negative someone may find. I think it's a mistake to sell vblt I said it in the past to a member and I say it now and I hope and believe I m right. I bought at price 9 and I may buy more although I told myself when 9 it's the last buying for me
I suggest u read past threads . If u look at presentation in their website u see the 9th patient lived 15.7 and the 9th is the median when 17 participated while in the graph and press releases he says 810 which is probably not true unless somebody can explain
The info u show prove they lie unless somebody can explain how 810 median turned to be 15.7 which is just over 400. Vblt is my biggest investment and these doubts about the honesty of CEO started back then when u first wrote about their lies. I was probably wrong when I thought the CEO is honest looking at what u and other have to say. I continue to hold vblt and I even bought a lot when the price was 9 because I also trusted ur estimated calculations and other calculations I saw by other forums that primary endpoint was already met. If again CEO is lying and 189 were already occurred then the results are weaker but October we know for sure 189 events didn't occur because CEO said it clearly. If primary endpoint was met in GLOBE I don't see a reason to sell but to buy more vblt the more the better. Vb111 can't lie and if we are unfortunate and the father of vb111 is a lier and a criminal then I m sorry for it but not going to sell my posotion
About the gbm they moved to speak 59 weeks but u may be right and here and there we still hear 15 months but ovarian I don't remember him mentioning 810 days in the past year and a half. When was the last time they talked 810 as median ? Also I think u urself doubted ur own conclusion in some way back then in case people continue to stay alive and I remember and can't find a reply to ur claim by members here explaining u did wrong determining the mos in ur calculations. Can u remind me pls what was ur own claim and what was the other member claim criticizing ur 810 false median statement ?
The ceo is super trusted. He played the game do u will get 7.5 dilution and not 5 or 6
I support this dilution and the high price of 7.5. It's a very high price. CEO played the game
U were right dilution
I prefer not to disclose but more than 20000
I bought today my last portion at price 9. I will wait for buyout or couple of years good luck
It's the first time he said that correct but I feel he said that in order to think about his sentence as a pause for his brain so he just added this if...
But I may be wrong and there is meaning to this comment like u think
5B is ok with me but I don't think will satisfy Dror haha
one more thing. things are different now, we have now patients with ovarian and cancer and thyroid that the cancer totally disappear and they live long period of time clean of cancer, they can show the data to the big pharma and since the patients are alive it is easy to check and test the validity of VBL claims. it is not like before that things were in the air now you have proof on the ground and very big sample together with the ph3 success in gbm
First VB-111 was tested as monotherapy with ph2 compelling results in Thyroid cancer, refractory thyroid cancer patients that were desperate after all therapy failed and stay alive until today very long term with no signs of cancer under monotherapy vb-111. it was also tested as monotherapy in lung cancer , neuroendocrine cancer and renal cancers with a patient alive over 7 years from ph1 mono so the no mono part of what you wrote is wrong.
Second it is obvious to me should be to you and of course it will be obvious to big pharma that if gbp results are positive and the ph2 was translated to phase 3 success then all the ph2 in easier indication which showed better results in the ph2 like thyroid and ovarian will pass the ph3 so this is also not an issue
If there is a buyout the buyout is for all solid tumor, I know it and if I know it big pharma knows it .
189 events already hit yes or no ? Chances of buyout after top line? Ur opinions please if yes assuming buyout after top line repeating ph2 success in rgbm would 5b will be the price or 10b to ur opinion ? Stock options started today to predict over 10 this year where are we heading this year when only ph3 trial initiation is on the table
I think there won't be financing in the near future and instead of u I buy vblt on Monday not beginning of market and not at the end but at some dead time middle of day and to compensate urself or myself I would be more aggressive and put more money than I had in price 5. The reason I think no financing is the thai Lee family they have their own agenda and will press against more dilution. Thai lee is half Korean she will tell him go partner with the Korean before u come with dilution ideas
I told u back then it was a mistake to sell. Being a doctor acted against u. Because as a doctor u know gbm won in past years and u considered vb111 just another one in the list. So far doctors failed in cancer and psychiatric diseases and more and every new drug raises questions of failure. I just studied dentistry but I m not a dentist I studied with doctors and unfortunately they considered what written in Harrison and other books as science while around 50% of what is written there is not science. Even car-t I suspect the job is not being made by the t cells injected as doctors represent it . I think it's just the mess it cause in immune system that attack the tumor but this mess cab be aroused without car t specifically. Vb111 if used properly is one of the best cancer drugs in the world if course not by using it once in 2 months giving summer school holiday for the cancer to kill u
I m not trading the stock but if u ask me they will pump it until earning and after earning the crash but this is pure gambling can be totally wrong. It's disappointing it took them 1.5 years to start phase 3 ovarian
The answer is yes I even took loans. By the way I start to believe car-t effect on tumor is not because of the t cells they inject but just because it mess with the immune system that attack the tumor. It's a dangerous treatment complicated expensive and I start to think it's not what the doctors say it's. I m against this path by vblt and I think they should neglect it
What is astm?
I read the messages here and other places and I think I m an alien. I m 100% sure vb111 met primary endpoint in GLOBE and I m 100% it will be met in OVAL. It's not 99% in my mind and not 99.9 but 100 this is why I understand I m so different than 95% of people. For me to read everybody message is like thinking are they out of their mind ? And I believe these people think the same about me. I read and I just can't believe what I read. To me people who have doubts about the success of these trials have zero superior vision because it obvious like the sun shine or not tomorrow in Sharm el sheikh
Wait for news too early to know
Why i ask it ? Because in car t again febrile patients react better it implies not the t cells they injected is doing the job
Offtopic what is the chance the effect of car-t is not the modified t cells they inject but the general immune stimulation the modified cells caused ? Vb111 is better than all drugs if used properly. Right now they pay the politics of fda but fighting the cancer u need an arsenal of variations of vb111 also raising doses and frequent administration
But ph2 rgbm vb111 we also have 10% durable. I think 2 patients are alive one from the group of sub therapeutic dose and 1 from high dose monotherapy correct me if I m wrong
The amount u mentioned are possible but not us are going to participate in the success . A buyout offer of between 5 to 10 billion and the ceo is selling it. I can understand him - the competition to vb111 the future competition will be taught it's not anymore avastin chemo radiation or some other crap but real anti cancer drugs
Is there any reference from other companies with failed compassionate use of their tech ? Is it allowed not to notify investors in case of negative update in patient with regard to esophagus ? Or they can just move on when they know it eventually failed
The mechanism of action is again immune response. The offered a mechanism but there is only one sure thing the immune system is doing the job if it's the initial virus or the fc following it that cause the immune response is not important. Any drug that keep gbm patients alive is very good news to the patients to society and to pharma companies. Imagine all gbm patients stay alive - the need for drugs will raise . I assume cancer will try to fight back and a combination or another drug is needed. Any new working drug including complete curing is always good news. The mechanism of working drugs will always be immune system that is doing the job I think it's not a competition in cancer drugs world but why to treat all cancer the same with vb111 ? Why to give once in 2 months to thyroid patients and also once in 2 months to gbm after all it's such a different cancer . The decision to stick with once in 2 months for every cancer is like fighting a 7 year old boy with same force u fight mike Tyson. I believe that being aggressive with vb111 in gbm you will get 50% complete responses and 20% durable for couple of years to forever