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WAS GIBT?
O.K., what's going on w/bouncy AVXL SP this A.M.? Looks positive so far. We are WAAAAYYYY overdue around here for some positive-supportive developments . BTW, if this is some kind of new game...BEWARE...some of us OLD TIMERS still have a few moves left. Most of us still believe AVXL is the REAL THING and that WGT. Carry On.
hnnbadger1..Thanks for this ref. article. Some objective evidence of efficacy. finally "Our cup is (at least) half full". IMO.
[quote“These data are very exciting, particularly in a study that can demonstrate objective slowing of markers of neurodegeneration,” Michael Weiner, MD, professor of radiology and biomedical imaging, medicine, psychiatry, and neurology at the University of California, San Francisco (UCSF) and principal investigator of the Alzheimer's Disease Neuroimaging Initiative (ADNI) said in a statement.1
One of the most common treatment-emergent adverse events in the respective safety population was dizziness, which was transient and mostly mild to moderate in severity. This adverse event was reported in 120 participants (35.8%) during titration and in 76 participants (25.2%) during maintenance with blarcamesine. In comparison, this adverse effect occurred in 10 participants (6.0%) during titration and 9 (5.6%) during maintenance with placebo.
“Alzheimer disease is such a devastating disease that affects tens of millions worldwide, and Anavex’s clinical development is a testament to our determination to follow the science,” Christopher U Missling, PhD, president and chief executive officer of Anavex said in a statement.1 “We like to thank all the people involved in the study for their invaluable contributions and we look forward to advancing blarcamesine as a potential new convenient orally available treatment option for Alzheimer disease.”
REFERENCES
1. Anavex’s Phase 2b/3 Trial of Blarcamesine (ANAVEX®2-73) in Patients with Alzheimer’s Disease Shows Robust Clinical Efficacy and Slows NeurodegenerationSignificant Reduction of Amyloid Beta Biomarkers of Alzheimer’s Pathology. News Release. Anavex Life Sciences. Published September 14, 2023. Accessed September 15, 2023. https://www.anavex.com/post/anavex-sphase2b-3trialofblarcamesine-anavex-2-73-inpatientswithalzheimer-sdisease][/quote]
hnbadger1:
6.98 +0.09 (+1.31%)
After hours: -
That's little better.
Jonjones
Thanks K9uwa...lets hope today and SP actions that follow today are (at least) honest and sensible. We despise liars.
Does anyone (who knows what they are talking about) want to tell us what the AVXL SP opening price is likely to be? (ball park est. is OK. )
Have to admit that today's sp action was a mess and (IMO) was obviously some kind of set-up for who knows what?
sab63090
abew4me
Ya Know, a guy could totally lose any remaining sense of humor on a day like this.
Cannot spike fast enough or far enough for some of us...BTW, we earned many consecutive days just like this...get used to it...TIA.
AB-E-NORMAL ...well, It's a START
D-Mike...
test ...8:39 am ...pilots and crews report to your ready rooms. Prepare the flight deck for air operations.
Bioinvestor5
WolfofMia
Dr.M., I need your help w/this. Have been here for years and support your team and the process all the way, but I have limits. Would appreciate any help you can offer right now. The sooner and bigger the better. TIA.
bas2020...
TOLD YA...Sigmar1...Anavex 3-71 ... treatments await..."Go AVXL"...https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501138/
WGTHAT, (HF) also
boi
Anyone have a rational explanation for this (looks like) massive collapse? Is it REALLY good news in some kind of trick disguise? or An indication the real bottom fell out of AVXL? Confusing me. Who gains by this selling??? Is this just some kind of WS trickery????...seriously
IMO, being LONG AND LOYAL means you have put up with the liars posts and the thieves dishonesty knowing all along you have studied the available facts from AVXL and the , "Buy In". If those inputs change then you may feel free to reconsider. Keep an open mind-thought process for new information/facts. You never go to sleep and your never leave AVXL staff behind in your thinking, even when it is a bad day. Semper fi...hold the line. Dr.M. will not let us down.
McM
NOW WHAT IS GOING TO HAPPEN ON MONDAY to SP ???TIA
One question has to be answered. Will FDA top decision makers want to get the 50+ years of Amyloid Thesis plaque AD-CNS cause behind them in one sweep , or not???? By signing up w/AVXL science and BIO markers they are able to snatch victory from the jaws of certain (very public) science failure . Yes, we all understand there will be deals cut while politics re-position their public message.
If Dr.M. is able to keep AVXL in sight while we work in the background to cement the language, then FDA can be helpful (by at least being quiet) while the real science gets published and understood.
A complex stew of science, image, results and lots of BIG $$$$ is in this POT. IMO, AVXL has presented a low profile so far which has not helped AVXL SP much but such posture may help get the FDA moving-motivated to work w/us. We do not need to rub their faces in a checkered history, IMO.
Bottom line is. It looks like AVXL has got the goods and can prove the results are the REAL THING. Now lets make it stick and cut some GREAT BIG deals .
Wolfofmia
https://finance.yahoo.com/news/anavex-phase-2b-3-trial-113000676.html
Some news we have been waiting to see..."Go with throttle UP..."
sab63090
Dr.M.
Excellent summary of the status and our future potential...it's all about the Bio-med process being followed. IMO, at some point all competition will be forced to fold camp and leave the field, Only a matter of time now.
Great work Plex...thx.