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In the long run, probably.
And NG will be used to generate some of those sparks.
But in the short to medium term, NG still has a real chance.
DW, it's reasonable to think the recharging time will be significantly cut in the near future, where sufficient line power is available.
The infrastructure to supply that power in rural areas is probably more problematic.
So is the vast amount of copper cable, rare earth metals, lithium, etc involved.
Copper is pretty cheap just now, but it's a volatile commodity.
It's a harsh market that refuses to recognize an important, newly approved blood cancer treatment!
Further, there's reason to assume it'll work for other blood cancers too. Thousands of hopeless victim's lives will be saved!
Really exciting!
And the Sp just squats there....sigh.
That's both disappointing and irritating.
Thanks Burrhead.
Small, cash flow negative bios like TPIV are plagued by loud mouths attempting to work the short term SP for petty profits.
By undermining the Tapimmune shareprice, they undermine the companies' ability to finance the necessary research and clinical trials.
The fact that the company is earnestly laboring away, working hard to end the agonizing, tragic deaths of thousands of victims,
bothers those SP parasites not-at-all!
Jack;
China makes grand pronouncements, but then often does the most pragmatic thing.
The immediate motivation for banning ICVs is air urban pollution...That's the source of the political pressure involved.
They are surely beating the pants off us in solar/wind and hydro power development, as well as virtual armies of new graduating engineers.... but...
It's hard to imagine heavy haulage across China's vast stretches powered by EVs for quite a long time.
Cleaner NGVs offer a bridge solution that'll probably be taken.
Well,the market sure didn't like that!!
We've been plummeting down in leaps and bounds ever since the announcement that management was going to cut back on new research and employees...
Then bet all on approval of one drug!
Some posters have been advocating that strategy for this and a few other small bios as it means less dilution.
But it seems to me to be both future limiting and shows a "hail-Mary"desperation.
It's the kind of action one might expect by a CEO appointed by a hedge-fund.
Let's let the new CEO do his thing and se what he can do...Way too soon to pout about his shareholder message.
He seems knowledgeable, experienced, personally involved and not as phony as a lot of small bio company CEOs.
TPIV has a long way to go before we have anything substantial past the FDA and in the bag.
In the meantime, the PPS will flop around like a dying snake, and the shorts and pumpers will jump on and attempt to ride it while spraying hyperbole. Don't let them bother you.
Keep your eyes on the science and clinical trials
Not much pop. growth in China now but their rise in economic level will necessarily be followed by growing transportation needs.
As cheap NG becomes more widely available, it's probable it's adaption becomes much more popular.
Quatar, with it's vast untapped NG reserves, has built a huge LNG facility and is building the fleet to deliver it anywhere. They can extract and sell NG much cheaper than anyone.
Um, the PPS is rising back closer to the true value of it's potential?
grin.
NG is cheap and abundant in the US and much of the Americas. There are considerable reserves untapped due the low price and there's the truly enormous amounts of methane hydrate waiting under the permafrost and in the colder water of the oceans ( deeper in warmer water).
As for the competition, such is capitalism.
Jack, i think you've firmly established that the PPS isn't anchored to any sort of reality, beginning from the stunning drop to a buck.
Oh Jack; while i was toasting the company's rise from the slough of despair; You had it stomped and stamped as throughly toasted , run-over roadkill ,from your position as a fat short .
While their chances of survival as a dedicated, small niche company are greater if they follow your vision; you do tend to be, um, short sighted. We'll need to keep exploring multiple options to thrive in the longer run.
Like the crash in oil prices, any number of events could change the future of this outfit dramatically for the better....or worse.
Even if oil prices remain low, pollution pressures in urban areas will continue to grow.
China's strangle hold on rare earth metals necessary for electric vehicles and the finite availability of easily extractable lithium are also apt to change the equation in the near future.
The great abundance of cheap NG remains a very strong motivator.
Hi Jack: there are just a few ZEV formats that have a real chance.
It'll be quite a number of years before "low emission vehicles "engines aren't good enough, i'd bet..
I think that most any industrialized nation, urban area lacking a consistent wind are our natural market.
I'm an old guy who grew up in LA and clearly recall eyes burning, asthma and air the color of a grocery sack.
The Smog laws were very unpopular at the time. Everybody who picked up a wrench hated them, Many still do. But you can actually breathe a lot of the time in SO CA now.
Vehicle emissions are a much easier target now.
If you've ever sat out city council meetings, you know that bus and garbage truck costs are debated endlessly, they care!
But the voters care about breathing a lot more.
I'm sure you've spent hours in traffic behind older, diesel muni buses, and enjoyed the money saving exhaust.
If you can't economically store the H2 fuel and/or if maintenance costs are prohibitively high because it leaks out of every vibrating joint and even slowly bleeds out of the walls of the tank and hoses...Then is sure does matter.
And if the sources of your 0 emission fuels are mostly dramatically emissive...Then what's the point?
Easy, i think the CAR-T therapies are only for blood cancers presently.
Our NEO and other individually tailored newer treatments are going to be similarly expensive.
The Lm constructs that we all invested in, are probably squatting on expired patents, or soon to be expired IP. ( Is this true now?)
Last, why aren't we renting out our expensive production facilities to other companies till we need them?
".Darn another missed opportunity! Oh well hopefully Mr. Lombardo will do a better job of running trials now hat Dan is gone!"
Say Easymoneyman...Do you see any evidence of that?
Hi Dew:
~"Missed opportunity?"
Think of all the cash we save that way for future executive bonuses!~
Hydrogen is such a small molecule that it's very difficult to store and handle...and it's aggressively explosive. Nothing leaks as well as pressurized H2.
Presently, most H2 is mostly derived from natural gas, if i recall correctly....And that process, like electrical generation sure isn't 0 emission!
Betting all on one drug candidate makes me kinda nervous, given the capriciousness of the FDA. Especially now that big swamp pharma has so much more influence.
So, let's see....
IONS announces a new clinical trial series for a drug that might command enormous , unserved markets;
Collects a fat wad of dollars,
and the PPS sinks over # 3%.
Riiiight! Rational market indeed.
"CARLSBAD, Calif., Oct. 13, 2017 /PRNewswire/ -- Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) today announced that it has initiated a Phase 1/2a clinical study of IONIS-MAPTRx in patients with mild Alzheimer's disease (AD). Ionis earned a $10 million milestone payment from Biogen related to the initiation of this study."
Seems obvious that a company who wanted us could just use hi-freq techniques to quietly buy up small lots of stock day after day until they had the better part of a controlling interest. A few front companies could make that pretty inconspicuous.
Even if they ran the price up some in the process, it would still come to them for relatively little.
Yeah, it oughta be labeled so folks who don't believe in science can continue to handicap themselves.
Probably better for the PPS this way though.
There were several references to incorporating long read sequencing in research in today's online Oncologist's Journal.
Pasted in one below.
That's the first time i can recall multiple references.
Just what we'd been hoping for!
Clinical Application of Targeted Deep Sequencing in Solid-Cancer Patients; Utility of Targeted Deep Sequencing for Biomarker-Selected Clinical Trial
Seung Tae Kim, Kyoung-Mee Kim, Nayoung K.D. Kim, Joon Oh Park, Soomin Ahn, Jae-Won Yun, Kyu-Tae Kim, Se Hoon Park, Peter J. Park, Hee Cheol Kim, Tae Sung Sohn, Dong Il Choi, Jong Ho Cho, Jin Seok Heo, Wooil Kwon, Hyuk Lee, Byung-Hoon Min, Sung No Hong, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Woong-Yang Park, Jeeyun Lee
Advances in sequencing technologies and improved algorithms for detecting specific molecular aberrations make it possible to perform biomarker-driven clinical trials. The analytical sensitivity and clinical validity have not yet been demonstrated in a large cohort. This article describes the implementation of a targeted-sequencing panel in a precision oncology clinic and the feasibility of a clinic-based molecular screening program
There's a whole little flock of new collaborations and clinical trials either in process or about to launch.
As is proper, we are up 7%!
While my other little bios just squat there, SG roars into the future.
We agree Ira:
In the face of a deadly disease, a reasonable person and even the FDA sometimes, accepts some unfortunate side effects
"A hypothetical drug that can cure one HER cancer, has a fairly good chance to cure other HER cancers.
Like a certain dog vaccine has a great chance of curing human cancers maybe, Shub?"
That's right Terry. That's why we were all excited about back when our IP was fresh and enforceable.
People are not so different from dogs in important ways.
And just to raise a bit of dust, medical testing on dogs before it's done on humans is common and important.
After all, here in the US we kill "euthanize" millions of dogs every year , dogs that nobody wants.
Terry; Even if our vaccine somehow caused a few % mortality as a nasty side effect,
but saved a significant % of folks with HER cancers...Then that would be very acceptable!
Check out the current mortality rate.
HER is a genetic identifier/ driving mechanism for a number of superficially unrelated cancers.
Each new treatment has different side effects, often unrelated to treatments that use different mechanisms..
A hypothetical drug that can cure one HER cancer, has a fairly good chance to cure other HER cancers.
A non specific response.
Well, you neither.
Your value set is clearly different than mine.
My guess is that you don't expect to live very long.
That leads to superficial, short term decisions.
As a sincere stockholder, not a mere trader;
I hope that we suffer no buyout.
We have serious longterm potential to make some real money.
Sit tight through the turbulence and have faith in our science.
Ideally, we can save lives and profit.
Thanks Georgejjl;
Both Folkman's name and D'Amato's appear across a surprisingly diverse range of fields. Literally awesome people!
Our culture is so stupidly stuck in a positive-negative, win-fail mind set that we learn less and less from our mistakes..
A self handicapping mindset.
Most every novel screw up. is a potential technique in another context....If we can learn from them.
It's true..Out of that disastrous drug error, CELG has changed the problematic chemistry and saved or benefitted millions of sick folks.
They've also done very nicely for my stock portfolio.
Every mistake is a learning opportunity.
Some of our most important medicines were discovered thus.
Sorry: redundant post...
Though it was worth saying twice..
Don't sell your shares to Qualcon!
Sigh:
That is NOT what i wanted to hear.
It is Not in the share holders best interest
and violates their fiduciary duty to us.
Can they do this without a majority of the shareholders?
Please don't give your shares to them!
We own a fast growing company in a strong position and Qualcom is neither. The premium they keep offering is dinky and insulting.
"Fraud alert" he says.
Nope, short alert.
Dizzle...You are peering into a mirror!
No war presently. More than i can say for the US.
You can fly there and visit tomorrow.
DD is the same as for most any small foreign company.
Israel has a heavy concentration of brilliant and productive bio experts. Like silicon valley for computers, Israel is the right place for a company like BLRX.
Have you moved to Switzerland yet?
Bourbon, i may be wrong, but i'm no short.
You've known me under the name Ironyworks on the YMB before we came here. It's been a long time and you should know me by now.
I'm mildly depressive, no positive thinker for sure, but never short.
How many years of promises? Too many for me.
Dadofmax thinks it'll be a whole new FDA soon. But it looks to me like it's been handed over to the tender mercies of BP and little guys like AVXL will not be any better off.
I do, sincerely hope i'm wrong, that i shouldn't have sold and that a treatment for ALZ comes forth...But i'm too old to keep waiting and not betting on it any more.
Hello again Dadofmarcmax:
You've been one of the most rational and informed voices here,
and i've great respect for you and your opinions.
Your inflammation hypothesis appears to be supported to some extent by other studies i've seen, and the amaloyd plaque doesn't appear to be causative.
That's why i stuck with AVXL as long as i did and had invested a fair chunk of my modest artist's income in it.
Voicing my negative opinion is a legitimate expression of my disappointment and hardly disingenuous.
I'm not a short, i've never shorted a stock. I expected volatility and you may recall that i spoke to encourage share holders when we hit unjustified lows in the past, as well as tried to damp irrational enthusiasm when it ran amuck.
But i also expected the company to dedicate every available penny into pushing the critical clinical trials forward;
and i expected a decent standard of transparency from management.
That didn't seem to be happening, hence my disillusionment.
I think newer shareholders should be forewarned so they can make their own judgments. The intention was informative, not manipulative.
I lost my faith in management, not the science.
A business like this can't prosper without both.
I'm a former AVXL shareholder, but after some years of slowly sinking, i took a harder look.
The science, which was why i bought initially, remains unproved . Management won't risk testing the initial tiny study's encouraging results with a large, properly conducted double blind study.
Talk if the big, definitive Ph 3 study drags on and on and it doesn't actually happen.
Management spends most of the money on itself and it's stock options.
They have a fine line of hope and hype that they sell to each successive wave of new investors. And, there's a chance that there's something to it...But that chance looks slimmer by the month.
I finally sold at a loss, like many others, and have slowly managed to cover most of it over the last year or so.
A measure of doubt and questioning is appropriate with AVXL
I sincerely hope i'm very wrong, and that there is a cure for ALZ here. We desperately need it.
Good luck folks!
It sure is an incoherent and dispersed bunch of properties.
I've avoided Twitter and FB between the tracking and the level of ambiguous BS.
Back in the '60s when i was in the local salt water aquarium business, we used ozone generators to control bacteria, etc. It's old tech now..Harsh but effective. The pot industry is growing fast , but is tumultuous.
The patio/snow services looks like it could be solid. The game pub stuff looks vulnerable to fad gusts.
The stock , basically, is a low end penny stock with several earmarks that'd invite the seasoned investor to run like crazy!
If management is very talented, it might do very well.