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Good afternoon Biophans...
Thanks you Krays...for clarifying the consolidation, agreed Pal...time to git er done...
How about those Cardinals...
ole bub and the dawgs
Good morning Biophans...
There is a new sheriff in town, from Texas...welcome aboard Pal...
Though some pholks may not agree with Molecule's skepticism...years of attending shareholder meetings and Biophan presentations together with his insightful posts here and on Raging Bull have served Biophans well these past few years.
All the best...Much obliged Nick...
ole bub and the dawgs
Good afternoon Biophans...
Few jobs as thankless as Message Board moderation...much obliged B9 Molecule...JMHO
Go Biophan...sis boom bah
ole bub and the dawgs
Good morning Biophans...
Agreed Pal...some news you can use...for a change...lots of good info at www.angioplasty.org but you have to dig for it...JMHO
http://www.ptca.org/voice/archives/2009_0113.html
Go Biophan...sis boom bah...
ole bub and the dawgs
Good Morning Biophans..
Wald...I agree...tight lipped is one thing...unresponsive is irresponsible...JMHO
ole bub and the dawgs
Good morning Biophans....
Thanks Krays...more news you can use...
http://www.foxbusiness.com/story/markets/industries/health-care/boston-scientific-buys-irish-stent-technology-company/
ole bub and the dawgs
Good morning Biophans...
I'm curious how many substantial shareholders of record today...would support an increased share authorization for a more appropriate amount of shares, given realistic guidance and expectations, from Biophan management.
This would be potentially useful information, which competent responsible management could factor into a strategic plan...JMHO
Anyone know the status of the BSX license renewals?
All the best...in 2009
ole bub and the dawgs
Good morning and Happy New Year Biophans...
Thanks Samcat...an appropriate benediction prayer...IMHO
Hoping to see an 8K filing on the status of BSX licensing renewal fees...soon.
Speaking of wishes...Allow me to reiterate a request for a BOD shareholder representative or two. Guidance would be nice too.
bah hum bub...
ole bub and the dawgs
Good morning Biophans...
Tech...the best team won...the Eagles came to play....the Cowboys were pitiful...congratulations to the Eagles and Giants fans...the NFC East is the most difficult division in the NFL...end of story.
Regarding Biophan...patience Tech...I continue to accumulate as funds permit.
A Happy and Prosperous New Year for all...
ole bub and the dawgs
Good morning Molecule....
You are correct...this is the first MRI contrast agent to market in the US...the point is...cardiovascular disease and angiography is moving steadily toward imaging innovations. You can't win em all...JMHO
Some pholks see Biophan as a glass half full...others half empty...JMHO I bet those Madoff investors wish they had some Biophan pixie dust about now...JMHO
more to come...still collating...
Merry Christmas...congrats on the Giants win over Carolina...
ole bub and the dawgs
Good morning Biophans...
Here's some news to contemplate in light of the BSX licenses...thanks to MBD for uncovering this lil nugget of news.
EPIX Pharmaceuticals Announces FDA Approval of Vasovist
First Imaging Agent Approved for Magnetic Resonance Angiography (MRA) in the U.S.
LEXINGTON, Mass.--(BUSINESS WIRE)--EPIX Pharmaceuticals, Inc. (NASDAQ:EPIX - News), a biopharmaceutical company focused on discovering and developing novel therapeutics through the use of its proprietary and highly efficient in silico drug discovery platform, today announced that the U.S. Food and Drug Administration (FDA) has approved for marketing its novel blood pool magnetic resonance angiography (MRA) agent, Vasovist® (gadofosveset trisodium), to evaluate aortoiliac occlusive disease (AIOD) in adults with known or suspected peripheral vascular disease. AIOD occurs when iliac arteries become narrowed or blocked and may prevent the sufficient transport of oxygen and/or blood throughout the body.
Vasovist is the first contrast agent approved for marketing in the United States for use with MRA, a non-invasive modality for imaging blood vessels. In 2007, there were approximately 1.3 million MRA procedures performed in the United States using contrast agents not specifically approved for this procedure. MRA is a less invasive procedure than x-ray angiography, allowing for reduced patient discomfort and recuperation time and unlike x-ray angiography, MRA does not expose patients to ionizing radiation. Vasovist had previously been approved for marketing in 34 countries outside the United States based on data from four multi-center, Phase 3 clinical trials that showed that Vasovist’s overall accuracy was similar to that of catheter-based x-ray angiography, as determined by blinded readings
“Vasovist is a first-in-class contrast agent with several unique characteristics that we believe will allow it to become a market leader in the United States,” said Elkan Gamzu, Ph.D., interim chief executive officer of EPIX. “It offers good resolution angiography, a high signal per dose, a long imaging window timeframe and single-dose imaging of multiple vessel beds. We believe the resulting high-quality image will allow physicians to fully utilize MRA as a meaningful diagnostic and therapeutic tool. In addition, the albumin-binding properties of Vasovist make it ideal for vascular imaging as opposed to other gadolinium agents that are rapidly cleared from the blood stream and have a narrow imaging window. There are no other imaging agents approved for MRA in the United States and we believe Vasovist will be well-received by the physician community as a valuable, safe tool for MRA. Our strategy remains to monetize this asset and we believe these characteristics and market dynamics make Vasovist an appealing opportunity for a company interested in building or augmenting its competitive position in the imaging market.”
The approval was based on the positive results from a blinded, independent re-read of images of Vasovist from previous Phase 3 studies. The re-read, which was conducted earlier this year, met all pre-specified endpoints prospectively agreed to with the FDA. In the re-read Vasovist was demonstrated to have:
* statistically greater sensitivity – readers of images using Vasovist more accurately detected disease when disease was present, compared with non-contrast MRA;
* statistically greater specificity – readers of images using Vasovist more accurately excluded disease if it wasn’t present at a rate that was not worse than non-contrast MRA;
* for scans deemed uninterpretable, Vasovist was demonstrated to have sensitivity and specificity that was significantly better than chance alone.
About Vasovist
Vasovist is an injectable intravascular contrast agent designed to provide improved imaging of the vascular system through magnetic resonance angiography imaging (MRA). Vasovist has been approved for marketing in the United States and in 34 countries outside the United States, including all 27 member states of the European Union, Switzerland, Turkey, Australia and Canada. Global marketing rights to Vasovist are held by Bayer Schering Pharma until March 1, 2009 at which time they transfer to EPIX. Vasovist is currently marketed in Canada and 18 European countries, including Germany, the Netherlands, Italy, all Nordic countries, the United Kingdom and Switzerland.
About AIOD and Peripheral Vascular Disease
Aortoiliac occlusive disease (AIOD) occurs when iliac arteries become narrowed or blocked. Arteries are normally smooth and unobstructed on the inside, but with age, plaque can build up in the walls of arteries and cause them to narrow and stiffen. Those affected with AIOD may not receive the blood and oxygen they need throughout their legs, causing pain, sores or gangrene, which can result in the loss of a limb. Peripheral vascular disease refers to diseases of blood vessels outside the heart and brain and includes functional peripheral vascular disease, which doesn’t have an organic cause or involve defects in blood vessels’ structure and organic peripheral vascular disease, which is caused by structural changes in blood vessels.
About MRA
Magnetic resonance angiography uses a powerful magnetic field, radio waves and a computer to produce detailed images of major blood vessels throughout the body. MRA may be performed with or without contrast material and is used in many diagnostic medical procedures including the identification of disease, aneurysms, and atherosclerosis; it is also used to guide surgeons making repairs to diseased blood vessels and plans for surgical operations.
About EPIX
EPIX Pharmaceuticals is a biopharmaceutical company focused on discovering and developing novel therapeutics through the use of its proprietary and highly efficient in silico drug discovery platform. The company has a pipeline of internally-discovered drug candidates currently in clinical development to treat diseases of the central nervous system and lung conditions. EPIX also has collaborations with leading organizations, including GlaxoSmithKline, Amgen and Cystic Fibrosis Foundation Therapeutics.
More about managing expectations a bit later...
Merry Christmas to all...
ole bub and the dawgs
Good morning Biophans...
Thank you Krays...for clarification...agreed it IS huge...JMHO
all the best...Go Dallas
ole bub and the dawgs
Good morning Biophans...
Thank you Krays...
Tech I think we are confused...it appears there are two or three important patents issued or allowed in the past two weeks.
Perhaps Krays, can provide some guidance...please.
Go Dallas...
ole bub and the dawgs
Good Afternoon Biophans....
Much Obliged Krays...
It make's perfect sense to have a MRI imageable controller assembly for the Myo-Vad heart cup. Perhaps this is the icing on the proverbial IP cake. Any chance someone can post an abstract of this patent?
A little guidance would be useful about now...JMHO
Merry Christmas...Go Dallas
ole bub and the dawgs
OT...Molecule...
Even a blind hawg finds an acorn ...now and then...
I suspect both QB's were very slow to rise this morning.
all the best...
ole bub and the dawgs
Good afternoon Biophans...
BSX receives FDA approval for first US Renal Stents...
http://biz.yahoo.com/prnews/081215/nem055.html?.v=71
Hmmmm....I wonder how they measure the percentage of stent restenosis so precisely?
Merry Christmas and a Prosperous New Year...
ole bub and the dawgs
Good afternoon Biophans...
The problem here is a failure to communicate guidance regarding the additional share authorization to the domestic and European shareholders.
A significant MyoTech CSS deal will alleviate some of those guidance concerns...JMHO
How about dem Cowboys...
ole bub and the dawgs
Good morning Biophans...
Uphillride...posted a clarification of the IP transfer to MDT...on the RB board...the absence of corporate guidance contributes to the confusion we see posted here and elsewhere....JMHO
Regarding the adjournment date for the shareholder voting...the 8K filed after the September 12th meeting, clearly states...December 1, 2008, as the adjournment date.
Biophans may want to review the "Letter to Shareholders" posted at the company website...from this past January...an interesting read in light of recent developments.
Merry Christmas...and a Happy New Year...Ho Ho Ho
ole bub and the dawgs
Good evening Biophans...
Pal...It's incumbent on the company to clarify the IP transferred to MDT and offer GUIDANCE for the shareholders...JMHO I've been requesting guidance for over a year.
It;s time for shareholder representatives on the BOD...I nominate Uphillride and Tetrahedron.
bah hum bub...git er done
ole bub and the dawgs
Good morning Biophans...
Here's a link to an interesting blog regarding cardiovascular imaging.
http://www.ptca.org/voice/archives/2008_1130.html
Pal...I'm not sure the nature of our relationship with Dr. Melzer. MBD, EP and I sat next to Dr. Melzer, while he prepared his laptop for his most impressive power point presentation during the 2005 shareholder meeting...a very interesting physician/researcher.
Perhaps the company will offer the results of the voting today?
Go Dallas...Biophan too...
ole bub and the dawgs
Gobble Gobble...Biophans...
News you can use...seems our imaging competition may not be competitive afterall...JMHO
http://www.cnn.com/2008/HEALTH/conditions/11/27/healthmag.heart.ct.angiography/
Go Dallas and Oklahoma State and Biophan...sis boom bah
ole bub and the dawgs
Good morning Biophans...
Excellent post Wald...I absolutely agree...
Company guidance is critical for continued shareholder support...JMHO
The Holidays are especially difficult for our fine folks serving overseas...pray for their safe return.
Happy Holidays...gobble gobble...Go Cowboys
ole bub and the dawgs
Good morning Biophans...
Nice to hear from you Andy....how is that Lincoln limo...LOL
Much obliged for the update and commentary...Dr. Tet...
Tis the time to be thankful for our bountiful blessings...JMHO
Been a while...Making Big Dough Dough....don't be such a stranger.
How about dem Cowboys...Go Oklahoma State...Biophan too...
gobble gobble...
ole bub and the dawgs
Good evening Biophans...
Biophan has a long history of collaboration with Dr. Wang....Krays.
Nice volume on a rising share price today...looks like the MM's even painted the tape mid session....hmmm
expecting the expected...
ole bub and the dawgs
Good morning Biophans...
Thank you for the insightful comments...Dr. Tet.
Sunspotter's comments belie a duplicitous agenda...as laughable as his "objective" moderation of Natural Nano, be it a hedge fund ,a hostile competitor(s) or a "short" his principal(s) may be a bit nervous...JMHO
I have never worked for the company nor have I received any compensation from Biophan...the difference between myself and Voldie...I own Biophan common stock...my money is where my mouth is...I voted yes, and encourage "longs" who have yet to vote to do the same..."tough love"..."forensic analyst"...I doubt it.
expecting the expected...
ole bub and the dawgs
Good afternoon Biophans...
Krays...I believe the shareholders of record date, was July 25th, 2008.
Nice to hear from Jazzer and Tet...JMHO
Sunspotter...
Monday morning quarterbacking is not my style. You either believe in Biophan's management and products or you don't...if not you sell or pass and move on...pretty simple really. Despite your incessant litany of innuendos and accusations...most of us are adults and in no need of a "nanny" forensic or otherwise, to protect us from ourselves...JMHO
expecting the expected...
ole bub and the dawgs
Good evening Biophans...
Much Obliged Pal...guess we are even on the Texas Tech/Oklahoma State wager.
Voldiemort/Sunspotter...you have no shame...you know the company was prohibited by the collateralization agreement to buy out the Iroquois folks with Medtronic proceeds...yet you intentionally mislead...who do you represent and why?.
Since we have a open board seat, let me be the first to nominate Tetrahedron, a Physician and significant long term shareholder to the Biophan Board of Directors, as a shareholder representative.
expecting the expected...how about dem Cowboys...both of em.
ole bub and the dawgs
Good morning Biophans...
Sunspotter...
Your intent is to rabble rouse, confuse and obfuscate while stirring the flames of mistrust and ill will.
The longs I know...have invested their time, treasure and trust...while sharing their due diligence with no hidden agenda.
No doubt your agency agreement precludes any admission of complicity.
The esteemed contributors to this message board know why they are here...but we are befuddled by your rapacious presence.
Agreed...guidance from management is woefully past due and ironic given recent developments...sometimes you have to trust the pholks you believe...and ignore the ones you don't.
Posting as Voldemort your incessant venom and prestidigitation of facts and figures contributed to the ruination of five years of rapport and trust built upon 120,000 plus posts on Raging Bull...you hounded and harassed Terry Hallinan on RB until he moved to an obscure board on Investor Village.
Posting as Sunspotter...you seem hell bent on bringing that same venom and chaos to IHUB...all in the name of a selfless compulsion to protect us from ourselves...pardon me if I don't believe you...JMHO
vaya con dios...adios
Go Biophan...Oklahoma State and Dallas...sis boom bah..
ole bub and the dawgs
Good morning Biophans...
Thank you Tet for the second opinion...please cross post your opinion on RB, in response to Nurseratchet's due diligence.
Agreed the table is being set...now where is that damn bird?
I thought the disclosure of Dr. Tisherman's consultancy to Velomedex and Biophan was particularly interesting especially in conjunction with Medtronics...JMHO
expecting the expected...Go Dallas...Go Pokes
ole bub and the dawgs
Good afternoon Biophans....
From the RB board courtesy of Nurseratchet...
http://circ.ahajournals.org/cgi/content/full/118/15/1585
hopefully some younger eyes will summarize the contents...
Go Dallas...Go Biophan...Go Pokes...
ole bub and the dawgs
Good morning Biophans...
Thanks for the info Chuck...
Perhaps that rule change accounts for today's "massive" volume....or rather lack thereof...LOL
expecting the expected...
ole bub and the dawgs
Oops...Krays...my bad...
I missed that post with these ole beady eyes...
much obliged...
ole bub and the dawgs
Good afternoon Biophans...
Be my guest...Krays...your welcome.
I noticed the LaViolette retirement video is no longer posted at Angioplasty dot org...pholks may have to visit the BSX website for that informative video.
saluting those who serve and served...
ole bub and the dawgs
Good morning Biophans...
A note of heartfelt gratitude to all Veterans who serve and have served our country so valiantly.
May God speed you home safely...and comfort those who sacrificed their beloved...Freedom is never free.
Steve Summar, SSgt. USAF, SAC, 4017th CCTS, 1967-74
Much obliged...Krays...
Your excellent DD posts are greatly appreciated...especially by cyber-challenged pholks like me...
Go BIPH....Dallas too...
ole bub and the dawgs
Good afternoon Biophans...
Excellent inquiry Krays...
Interested pholks may want to visit angioplasty dot org and watch BSX's retiring CEO Paul LaViolette video comments regarding their next generation of DES...check the home page in the current news section scroll down to early June.
The FDA lifted their punitive restrictions on BSX effective this past October, enabling a 32 month backlog of products in the BSX clinical trials pipeline to be submitted for FDA approval...expecting the expected.
Go Dallas...Go Pokes...how about those Red Raiders....
ole bub and the dawgs
Good morning Biophans...
May I humbly request...the company management offer some realistic GUIDANCE...while our significant shareholder base continues to erode...enough is enough.
git er done...
ole bub and the dawgs
Good morning Biophans...
Well said Wald, Krays and Tet...at this point if you know what you own, you either believe in the company and it's IP or you don't...if you don't ...why are you still here...JMHO I've been long this company for five years in January, I'm a bit weary of the incessant bashing by a few miscreants with hidden agendas...JMHO
I'm more concerned about the self appointed "Nanny state" designees, protecting us from ourselves...than I am a 225% increase in treasury stock.
Reminder...Republicans vote today...Democrats voting multiple ballots...vote tomorrow...LOL
expecting the expected...git er done...Go Oklahoma State
ole bub and the dawgs
Good afternoon Biophans...
Titan...Wald is a trusted long time poster here, if he says he was called...I believe him...hopefully the company will provide guidance on this matter.
expecting the expected...
ole bub and the dawgs
Excellent Due Diligence...Krays...
Nice to see the company dotting the I's and crossing the T's...the devil is in the details...JMHO
Looks like MyoTech CSS is positioning to become a therapeutic player rather than a "bridge" player...JMHO
we like it...Go big D...trick or treat
ole bub and the dawgs