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Money $hot Free

03/06/20 10:10 AM

Post #137

$AGNPF Algernon Explores the Use of NP-120 (Ifenprodil) as a Novel Treatment for Coronavirus

VANCOUVER, British Columbia, March 06, 2020 (GLOBE NEWSWIRE) -- Algernon Pharmaceuticals Inc. (CSE: AGN) (FRANKFURT: AGW) (OTCQB: AGNPF) (the “Company” or “Algernon”) a clinical stage pharmaceutical development company is pleased to announce that it is exploring the potential of using NP-120 (Ifenprodil) as a novel treatment for COVID-19, also known as the coronavirus. A recent independent study found that Ifenprodil significantly reduced acute lung injury (ALI) and improved survivability in an animal study with H5N1 infected mice. H5N1 is the most lethal form of influenza known to date with an over 50% mortality rate.

Based on this study, published by the American Society of Microbiology in mSystems in the December 2019 issue, the Company believes that Ifenprodil has the potential to be a front-line treatment for the most severe cases of coronavirus, and may also reduce morbidity in patients. Coronavirus currently has an overall predicted mortality rate of approximately 4%. Management’s belief that Ifenprodil is a possible treatment for COVID-19 is based on historic animal studies and not on human trials.

Despite the overall mortality rate of 4% based on current data, coronavirus-infected patients experience sometimes profound pulmonary complications including lung infiltrates, opacification, and risk of adult respiratory distress syndrome. Beyond systemic steroid therapy, clinicians have few agents with which to treat these patients and Ifenprodil may offer a new and efficacious treatment option that limits inflammatory infiltrates and the resulting fibrotic responses, as suggested in its earlier animal model studies.

Ifenprodil H5N1 Animal Study Background:

A genome wide RNAi interference approach to identify genes that aid in the recovery of cell viability after H5N1 infection, lead to the identification of the NMDA receptor antagonist Ifenprodil, which when tested in an animal model of H5N1 infection showed:

Markedly decreased leukocyte infiltration and lung injury scores in effected lungs
Significantly ameliorated edema infected mouse lung tissue
Significantly improved the survival of H5N1 infected mice by 40%
Study Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906739/

The company believes these findings could be relevant for reducing the lung-associated complications of coronavirus infection.

Algernon is preparing to apply for ethics approval in Australia for Ifenprodil, for its planned phase 2 clinical trial for idiopathic pulmonary fibrosis (IPF) and chronic cough.

“The Company has begun a process to review the potential of Ifenprodil as a novel treatment option for coronavirus”, said Christopher J. Moreau CEO of Algernon Pharmaceuticals. “Ifenprodil is a known, and approved safe drug that has been on the market in Japan for over 20 years and could be repurposed quickly to help in the treatment of the disease.”

Algernon has filed new intellectual property rights for NP-120 (Ifenprodil) for the treatment of respiratory diseases.

About NP-120 (Ifenprodil)

NP-120 (Ifenprodil) is an N-methyl-d-aspartate (NDMA) receptor glutamate receptor antagonist specifically targeting the NMDA-type subunit 2B (Glu2NB). Ifenprodil also exhibits agonist activity for the Sigma-1 receptor, a chaperone protein up-regulated during endoplasmic reticulum stress. Although the anti-fibrotic activity of Ifenprodil in IPF is not known, recent studies have suggested a link between both receptors and pathways associated with fibrosis.

NP-120 (Ifenprodil - brand name Cerocal) was initially developed by Sanofi in the 1990s in the French and Japanese markets for the treatment of circulatory disorders. The drug is genericized and sold in Japan.

About Algernon Pharmaceuticals Inc.

Algernon Pharmaceuticals is a clinical stage pharmaceutical development company focused on advancing its lead compounds for non–alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF), and chronic cough.

CONTACT INFORMATION

Christopher J. Moreau
CEO
Algernon Pharmaceuticals Inc.
604.398.4175 ext 701

info@algernonpharmaceuticals.com
investors@algernonpharmaceuticals.com
www.algernonpharmaceuticals.com

The CSE does not accept responsibility for the adequacy or accuracy of this release.

Neither the Canadian Securities Exchange nor its Market Regulator (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release. The Canadian Securities Exchange has not in any way passed upon the merits of the proposed transaction and has neither approved nor disapproved the contents of this press release.

CAUTIONARY DISCLAIMER STATEMENT: No Securities Exchange has reviewed nor accepts responsibility for the adequacy or accuracy of the content of this news release. This news release contains forward-looking statements relating to product development, licensing, commercialization and regulatory compliance issues and other statements that are not historical facts. Forward-looking statements are often identified by terms such as “will”, “may”, “should”, “anticipate”, “expects” and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include the failure to satisfy the conditions of the relevant securities exchange(s) and other risks detailed from time to time in the filings made by the Company with securities regulations. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable law.

http://www.globenewswire.com/news-release/2020/03/06/1996401/0/en/Algernon-Explores-the-Use-of-NP-120-Ifenprodil-as-a-Novel-Treatment-for-Coronavirus.html

/////AMG

ForzaFerrari Free

04/27/12 4:19 PM

Post #136

Re: #135: @rbl100 - How do I get free level 2? I

Sorry, IHUB had a glitch that day and I had free L2 for that day only.

rbl100

04/26/12 12:59 PM

Post #135

How do I get free level 2? I never got anything free here except harassment by others... I even saved those posts for future payback.

ForzaFerrari Free

04/24/12 1:29 PM

Post #134

Re: #133: @Daylas - Great call!

Thanks, that was one of the easier ones. They got billions coming out of their ears lol!

Daylas

04/06/12 1:50 PM

Post #133

Re: #124: @ForzaFerrari - AAPL is about to test the 200 day

Great call!

ForzaFerrari Free

07/14/11 11:41 PM

Post #132

Hey IHUB, thanks for the free L2. :p, jk, I know you're having technical difficulties lol.

ForzaFerrari Free

06/30/11 11:52 PM

Post #131

Re: #130: @FatFingers - Nice play!

Have a great long weekend buddy, cheers!

FatFingers Free

06/29/11 2:29 AM

Post #130

Re: #129: @ForzaFerrari - Small money, but I'll take the %200+

Nice play!
I'll take 200% any day

ForzaFerrari Free

06/29/11 2:23 AM

Post #129

Re: #86: @ForzaFerrari - Got in @ .0125, small money, as that

Small money, but I'll take the %200+

ForzaFerrari Free

06/24/11 4:36 PM

Post #128

Re: #117: @ForzaFerrari - Below $80 now tho...

And below $70 now, sometimes its just too easy to predict...

ForzaFerrari Free

06/24/11 4:35 PM

Post #127

Re: #118: @ForzaFerrari - Can't hold high up, always a seller or

Looking ok now... Better next week IMO.

ForzaFerrari Free

06/24/11 4:35 PM

Post #126

Re: #114: @ForzaFerrari - Thanks for the posts guys. JBII is

$4 hit, holding ok as well, should dip a lil before hitting $5.

ForzaFerrari Free

06/24/11 4:34 PM

Post #125

Re: #116: @ForzaFerrari - CVSL holding the gains for now.

CVSL still up nicely this week, looking for 3 cent break next week, would be huge!

ForzaFerrari Free

06/10/11 4:07 PM

Post #124

AAPL is about to test the 200 day for the first time in quite a while. If you are not buying shares at this level, you are an idiot.

ForzaFerrari Free

06/10/11 4:02 PM

Post #123

Re: #104: @ForzaFerrari - OPMG explosion!

Still holding this lil guy.

ForzaFerrari Free

06/10/11 4:00 PM

Post #122

Re: #110: @ForzaFerrari - JBII Chart May 26th, 2011

Still holding and climbing, thought would see $4 this week, was wrong, but sitting nicely @ 3.50 atm.

ForzaFerrari Free

06/10/11 3:59 PM

Post #121

Re: #120: @ForzaFerrari - Didn't back in a lot because I think

But after it bounced off the $2 today, I grabbed a few at $2.03.

ForzaFerrari Free

06/10/11 3:58 PM

Post #120

Re: #119: @ForzaFerrari - Bought back into SIRI today. Had held

Didn't back in a lot because I think it will see 1.90, even 1.75 before it gets back into the mid 2's.

ForzaFerrari Free

06/10/11 3:58 PM

Post #119

Bought back into SIRI today. Had held from 1.90 sold @ 2.20.

ForzaFerrari Free

06/10/11 3:47 PM

Post #118

Re: #116: @ForzaFerrari - CVSL holding the gains for now.

Can't hold high up, always a seller or two or three to knock it down.

ForzaFerrari Free

06/10/11 3:47 PM

Post #117

Re: #103: @ForzaFerrari - Who wants to bet LNKD closes below $80 tomorrow!>

Below $80 now tho...

ForzaFerrari Free

06/07/11 12:11 PM

Post #116

Re: #115: @ForzaFerrari - CVSL pop!

CVSL holding the gains for now.

ForzaFerrari Free

06/03/11 3:01 PM

Post #115

Re: #84: @ForzaFerrari - CVSL Chart

CVSL pop!

ForzaFerrari Free

05/27/11 12:23 PM

Post #114

Re: #113: @mikeo56 - Falls business turns plastic into fuel

Thanks for the posts guys. JBII is up nicely today, IMO we will see $4 next week.

mikeo56

05/26/11 8:38 PM

Post #113

Re: #112: @Rawnoc - mikeo56 Share

Falls business turns plastic into fuel
http://www.wivb.com/dpp/news/niagara/Fal...
Wonder if it will make the National news soon? Whatcha think?

Updated: Thursday, 26 May 2011, 6:45 PM EDT
Published : Thursday, 26 May 2011, 6:45 PM EDT

* Rich Newberg
* Posted by: Eli George

NIAGARA FALLS, N.Y. (WIVB) - Imagine turning scraps of plastic into usable fuels. Some creative minds are making the idea into a reality, and it's happening right in Niagara Falls.

Currently, some 30 million tons of waste plastic in the U.S. goes to landfills. Plastic is made from oil, and now a company called J.B.I. based in Niagara Falls has found a way to convert the plastic back to oil.

This is no ordinary ribbon cutting. It may very well be the inauguration of a new era that converts waste plastic, like packaging from meat plants and scrap from auto factories, to usable gasoline, diesel fuel, home heating oil, and natural gas.

JBI President and CEO John Bordynuik said, "The fuel reproduces cleaner than the fuels currently found in industry, due to the fact that plastics is already a highly refined hydrocarbon."

Plastic items we're all familiar with at home can become raw material for the process. The plastic is shredded first and then heated up into a gas. The processor, through a special catalyst, cracks the hydrocarbon chains in the plastic and separates out usable fuel.

"There's your fuel there That's it. This is heating oil right here. This is Number 2 Spec Fuel Oil," said Bordynuik.

It gets filtered and then pumped right into a tanker truck outside the plant. A factory in Canada will use the product to make plastic pipes. Niagara Falls is hoping the plastics-to-oil manufacturing process will expand and create more green jobs.

Niagara Falls Mayor Paul Dyster said, "Every waste hauler in the United States, Canada, and a lot of other places, is going to have one of these units located on site, because now they can take plastic they would otherwise pay to landfill, and they can convert it into fuel to run their vehicles."

The creative development for the process started in this lab less than two years ago. A couple of pints of oil could be produced a day. The current plant produces 109 barrels a day. In two more years, the goal is to produce 20,000 barrels a day, and there's no shortage of plastic.

Bordynuik said, "We received 18 pallets of these alone last week. About 40,000 pounds we received. That's a lot of plastic, but to us, it's a lot of fuel. This is 109 barrels of fuel. 4,400 gallons of diesel."

The natural gas produced is used to heat and run the process. JBI created 40 green jobs to run the plant.

Copyright WIVB.com

Rawnoc

05/26/11 6:58 PM

Post #112

Re: #109: @ForzaFerrari - Cannot believe JBII is still above $3!

mikeo56 Share Thursday, May 26, 2011 5:08:51 PM
Re: Rawnoc post# 4064 Post # of 4071

Big media event today at JBI - encourage everyone to watch CHCH Channel 11 - Hamilton tonight at 6:00 and channels 2 and 4 Buffalo at 5:00 - CNN may pick up story as well
Also websites for each station.

Taken from the JBII board

ForzaFerrari Free

05/26/11 6:30 PM

Post #111

Re: #94: @ForzaFerrari - RFMK Chart May 13th, 2011

POS!

ForzaFerrari Free

05/26/11 6:02 PM

Post #110

Re: #109: @ForzaFerrari - Cannot believe JBII is still above $3!

JBII Chart May 26th, 2011

ForzaFerrari Free

05/26/11 6:01 PM

Post #109

Cannot believe JBII is still above $3!

ForzaFerrari Free

05/26/11 6:00 PM

Post #108

Re: #107: @ForzaFerrari - OPMG Chart May 24th, 2011

Maybe a long term play here, but as with most pennies, prolly not.

ForzaFerrari Free

05/24/11 5:55 PM

Post #107

OPMG Chart May 24th, 2011

ForzaFerrari Free

05/24/11 5:52 PM

Post #106

Re: #103: @ForzaFerrari - Who wants to bet LNKD closes below $80 tomorrow!>

It didn't!

FatFingers Free

05/20/11 9:01 PM

Post #105

Re: #104: @ForzaFerrari - OPMG explosion!

OPMG was a nice play for today!

ForzaFerrari Free

05/20/11 10:14 AM

Post #104

OPMG explosion!

ForzaFerrari Free

05/19/11 6:00 PM

Post #103

Who wants to bet LNKD closes below $80 tomorrow!>

ForzaFerrari Free

05/19/11 2:03 PM

Post #102

Re: #64: @ForzaFerrari - AAPL AIG or EXPE?

EXPE probably was the best pick to date, mind you right now AAPL looking like a strong buy, as if could have grabbed shares under $340 last days.

ForzaFerrari Free

05/18/11 6:14 PM

Post #101

Re: #74: @ForzaFerrari - ABT, R, QEC, RMX, RSI, SAS, SGR, STP,

Ah was Canadian TV, no wonder lol!

ForzaFerrari Free

05/18/11 6:13 PM

Post #100

Re: #99: @ForzaFerrari - Wow, actually hit 84 cents? As if

Should have sold my 3300 shares above 50 cents, not at 10. D'uh!

ForzaFerrari Free

05/18/11 6:05 PM

Post #99

Re: #98: @ForzaFerrari - From 60 cents back down to under 30!>

Wow, actually hit 84 cents? As if couldn't make $1.

ForzaFerrari Free

05/18/11 6:02 PM

Post #98

Re: #82: @ForzaFerrari - BCCI Chart May 10th, 2011

From 60 cents back down to under 30!><?

ForzaFerrari Free

05/18/11 6:01 PM

Post #97

Re: #86: @ForzaFerrari - Got in @ .0125, small money, as that

Still waiting on some news here I believe.

ForzaFerrari Free

05/18/11 6:00 PM

Post #96

Re: #38: @ForzaFerrari - Looks like I may be wrong here, at

Was 100% wrong here, only way to make money was flipping .0003's to .0004, which I don't do.

FatFingers Free

05/13/11 9:01 PM

Post #95

Re: #93: @ForzaFerrari - FBCD Chart May 13th, 2011

that is one good looking chart!

ForzaFerrari Free

05/13/11 4:48 PM

Post #94

RFMK Chart May 13th, 2011

ForzaFerrari Free

05/13/11 4:45 PM

Post #93

FBCD Chart May 13th, 2011

ForzaFerrari Free

05/13/11 4:43 PM

Post #92

SFIO Chart May 13th, 2011

ForzaFerrari Free

05/13/11 4:41 PM

Post #91

Re: #89: @FatFingers - oh yea!!!

PSPW Chart May 13th, 2011

ForzaFerrari Free

05/12/11 4:14 PM

Post #90

PSPW pop! SFIO pop! TYTN pop!

Do you see the pattern? I do: Every stock that I do not buy, flies!

FatFingers Free

05/12/11 12:20 PM

Post #89

Re: #88: @ForzaFerrari - Nice one, you must be loving PSPW and

oh yea!!!
my portfolio is GREEN GREEN GREEN!!!
CVSL is looking great for us!!!
i'm also holding FBCD
it's been a good week to say the least, lol

ForzaFerrari Free

05/12/11 12:18 PM

Post #88

Re: #87: @FatFingers - I'm also holding a position in CVSL

Nice one, you must be loving PSPW and CVSL green today!

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Andy's stock picks!

Followers	4	Posters	18
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Welcome to Andy''s stock picks! (with two apostrophes).

This board is for discussion of any stock. Be polite, no personal attacks, try to stay on topic as much as possible, and be positive.

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A list of common acronyms:

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www.investopedia.com/ More educational info on trading, a lot of your questions can be answered here.

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