SYRS

Syros Pharmaceuticals Inc

NASDAQ

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SYRS

Syros Pharmaceuticals Inc

NASDAQ

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chemist72

07/24/23 11:46 AM

Post #46

Re: #44: @Mr. Money$ - $SYRS: Does anyone have any information on Syros

Syros Pharmaceuticals (SYRS) Stock Forecast & Price Target
Follow - 643 Followers
Moderate Buy - 2
Buy - 2
Hold - 0
Sell - 0
Based on 2 analysts giving stock ratings to Syros Pharmaceuticals in the past 3 months
SYRS Stock 12 Months Forecast - $15.00 ?(337.32% Upside)

https://www.tipranks.com/stocks/syrs/forecast

Mr. Money$ Free

04/10/23 9:52 AM

Post #45

$SYRS: Stock moves quickly on low volume. Large healthcare funds are holding positions

Mr. Money$ Free

04/10/23 9:50 AM

Post #44

$SYRS: Does anyone have any information on Syros Pharma? Word on the street says they filed an S3 prior to announcing big news. Your thoughts? The stock seems to move quickly on low volume. Should I hold or sell? Thanks

Bullish

splintered sunlight PremiumMember

11/14/22 4:43 PM

Post #43

Brookline Capital Markets remains a Buy on SYRS with a $60 Price Target.

Spread the word.

splintered sunlight PremiumMember

10/03/22 12:53 PM

Post #42

Re: #41: @OCEANIC 815 - TD Ameritrade has SYRS Short % of float

Then lets hope for 2...

OCEANIC 815 Free

09/30/22 10:26 AM

Post #41

TD Ameritrade has SYRS Short % of float is 130%. If just one drug pans out - major short squeeze. No idea of that will happen but having a little in it is worth it.

INFINITI

09/16/22 4:10 PM

Post #40

Re: #39: @knrorrel - SYRS come dollar a/h ? weeeé

Don’t see it happening

knrorrel

09/16/22 4:08 PM

Post #39

Re: #38: @INFINITI - Let’s break that dollar and open @ $50

SYRS come dollar a/h ? weeeé
SYRS moving up WOWZAAAA

SYRS come dollar a/h ? weeeé

https://www.nasdaq.com/market-activity/stocks/syrs/real-time

INFINITI

09/13/22 7:04 PM

Post #38

Re: #37: @PennyPusher786 - This one is bound to pop to 1+

Let’s break that dollar and open @ $50

PennyPusher786 Free

09/13/22 6:23 PM

Post #37

Re: #36: @INFINITI - Awesome NEWS!!!!

This one is bound to pop to 1+ again... yesterday i loaded .70s mid day and was about to get out srouns 1.08, but watched it touch 1.16 or so.... analysts all calling anywhere from $4-$19 on this one.

INFINITI

09/13/22 4:11 PM

Post #36

Awesome NEWS!!!!

INFINITI

09/13/22 4:10 PM

Post #35

Syros Receives FDA Orphan Drug Designation for SY-5609 for the Treatment of Pancreatic Cancer

Source: Business Wire
Syros Pharmaceuticals, Inc. (NASDAQ:SYRS), a leader in the development of medicines that control the expression of genes, today announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation (ODD) to SY-5609 for the treatment of pancreatic cancer. SY-5609, a highly selective and potent oral cyclin-dependent kinase 7 (CDK7) inhibitor, is currently being evaluated in combination with chemotherapy for the treatment of patients with relapsed metastatic pancreatic cancer.

“This orphan drug designation underscores the urgency of our efforts to develop SY-5609 for patients with pancreatic cancer, one of the most devastating and difficult to treat malignancies,” said David A. Roth, M.D., Chief Medical Officer of Syros. “Based on the early data we reported last year, which demonstrated single-agent activity in heavily pre-treated patients, as well as compelling preclinical data and a strong mechanistic rationale, we believe SY-5609 could deliver meaningful benefit to people with pancreatic cancer, whose tumors have otherwise eluded therapeutic intervention. We look forward to sharing initial data from the safety lead-in portion of our ongoing Phase 1 study later this year.”

The FDA's Office of Orphan Drug Products grants orphan status to support development of medicines for the treatment of rare diseases that affect fewer than 200,000 people in the United States. Orphan drug designation may provide certain benefits, including a seven-year period of market exclusivity if the drug is approved, tax credits for qualified clinical trials and an exemption from FDA application fees.

Syros’ ongoing Phase 1 trial is evaluating SY-5609 in combination with chemotherapy in pancreatic cancer patients who have progressed following treatment with FOLFIRINOX. Patients were randomized to receive either SY-5609 in combination with gemcitabine, or SY-5609 in combination with gemcitabine and nab-paclitaxel, at the approved doses of the combination agents. The study is assessing safety and tolerability, as well as efficacy measures such as disease control rate and progression free survival. Safety and clinical activity data from the safety lead-in portion of the trial are expected in the second half of 2022.

Under an existing clinical supply agreement with Roche, Syros is also supplying SY-5609 for a combination dosing cohort in Roche’s ongoing Phase 1/1b INTRINSIC trial. This cohort is evaluating the combination of SY-5609 and atezolizumab in patients with BRAF-mutant colorectal cancer. Roche is the sponsor of the INTRINSIC trial.

About Syros Pharmaceuticals
Syros is redefining the power of small molecules to control the expression of genes. Based on its unique ability to elucidate regulatory regions of the genome, Syros aims to develop medicines that provide a profound benefit for patients with diseases that have eluded other genomics-based approaches. Syros is advancing a robust clinical-stage pipeline, including: tamibarotene, a first-in-class oral selective RARa agonist in RARA-positive patients with higher-risk myelodysplastic syndrome and acute myeloid leukemia; SY-2101, a novel oral form of arsenic trioxide in patients with acute promyelocytic leukemia; and SY-5609, a highly selective and potent oral CDK7 inhibitor in patients with select solid tumors. Syros also has multiple preclinical and discovery programs in oncology and monogenic diseases. For more information, visit www.syros.com and follow us on Twitter (@SyrosPharma) and LinkedIn.

Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, including without limitation statements regarding Syros’ clinical development plans with respect to SY-5609, the potential of SY-5609 to deliver meaningful benefit to people with pancreatic cancer, the timing of anticipated data readouts and potential regulatory submissions from Syros’ clinical trials, and the potential for Syros’s product candidates to obtain regulatory approval. The words ‘‘anticipate,’’ ‘‘believe,’’ ‘‘continue,’’ ‘‘could,’’ ‘‘estimate,’’ ‘‘expect,’’ “hope,” ‘‘intend,’’ ‘‘may,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predict,’’ ‘‘project,’’ ‘‘target,’’ ‘‘should,’’ ‘‘would,’’ and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including Syros’ ability to: advance the development of its programs, including tamibarotene, under the timelines it projects in current and future clinical trials; demonstrate in any current and future clinical trials the requisite safety, efficacy and combinability of its drug candidates; sustain the response rates and durability of response seen to date with its drug candidates; successfully develop a companion diagnostic test to identify patients with the RARA biomarker; obtain and maintain patent protection for its drug candidates and the freedom to operate under third party intellectual property; obtain and maintain necessary regulatory approvals; identify, enter into and maintain collaboration agreements with third parties; manage competition; manage expenses; raise the substantial additional capital needed to achieve its business objectives; attract and retain qualified personnel; and successfully execute on its business strategies; risks described under the caption “Risk Factors” in Syros’ Annual Report on Form 10-K for the year ended December 31, 2021 and Quarterly Report on Form 10-Q for the quarter ended June 30, 2022, each of which is on file with the Securities and Exchange Commission; and risks described in other filings that Syros makes with the Securities and Exchange Commission in the future. In addition, the extent to which the COVID-19 pandemic continues to impact Syros’ workforce and its clinical trial operations activities, and the operations of the third parties on which Syros relies, will depend on future developments, which are highly uncertain and cannot be predicted with confidence, including the duration and severity of the pandemic, additional or modified government actions, and the actions that may be required to contain the virus or treat its impact. Any forward-looking statements contained in this press release speak only as of the date hereof, and Syros expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220913006229/en/

Media:
Brittany Leigh, Ph.D.

Expensivetaste281 Free

09/12/22 7:48 PM

Post #34

Re: #33: @PennyPusher786 - Lol.... They wanna load the boat before it

Thanks

PennyPusher786 Free

09/12/22 7:40 PM

Post #33

Re: #32: @Expensivetaste281 - Why

Lol.... They wanna load the boat before it runs for those analyst targets

Expensivetaste281 Free

09/12/22 7:39 PM

Post #32

Re: #31: @PennyPusher786 - Dark Pool Trades dumping on the run

Why

PennyPusher786 Free

09/12/22 6:22 PM

Post #31

Dark Pool Trades dumping on the run

PennyPusher786 Free

09/12/22 6:07 PM

Post #30

Wooooohooo, got in just in time, 15 minutes ago! Thanks to After Hours trading. Gluck to all!

cardvic

08/17/22 4:11 AM

Post #29

Re: #28: @mcsharkey - On the Merger with TYME Pharma coming soon.

My advice is sell as soon as possible.

mcsharkey

08/01/22 4:12 PM

Post #28

On the Merger with TYME Pharma coming soon.
Annual shareholders' meeting and proxy vote ALWAYS IN August. Syros already had thei=s in June. About 1 .onth before the Merger announcement.

We ALL have to vote on it as a matter of course. The major holders already registered as being compliant with Boards of Directors.

From TYME Investor Relations today: "The meeting details will be disclosed within the next week or so."

After initial & minor PPS SURGE by SYRS on announcement, we've both stagnated.

My opinion? We'll have a joint meeting with merger consumated during it.

One big, happy family.

splintered sunlight PremiumMember

07/14/22 9:17 AM

Post #27

Re: #26: @cardvic - I think its good...yes good...well maybe not really

Hopefully $5!!!

cardvic

07/14/22 3:43 AM

Post #26

Re: #25: @splintered sunlight - Anything good to say about SYRS?

I think its good...yes good...well maybe not really good. OK, Im going to say somewhat good. I will let your know how good when it reaches either 5.00 or .13

splintered sunlight PremiumMember

02/17/22 3:10 PM

Post #25

Re: #24: @XenaLives - SY-1425 Our lead drug candidate, SY-1425, is a first-in-class

Anything good to say about SYRS?

XenaLives

09/29/20 8:24 AM

Post #24

SY-1425
Our lead drug candidate, SY-1425, is a first-in-class selective oral retinoid acid receptor alpha (RARa) agonist in a Phase 2 clinical trial in a genomically defined subset of patients with acute myeloid leukemia.

SY-5609
Our second most advanced program, SY-5609, is highly selective and potent oral cyclin-dependent kinase 7 (CDK7) in a Phase 1 trial in patients with advanced breast, colorectal, lung or ovarian cancer, or with solid tumors of any histology with an Rb pathway alteration.

https://www.syros.com/programs

XenaLives

09/29/20 8:15 AM

Post #23

An Expression Makes a World of Difference
The genes expressed - turned on, off, up or down - in any given cell determine its type and function. When the wrong genes are expressed at the wrong time or in the wrong amounts, it can lead to disease.

At Syros, we are redefining the power of small molecules to control the expression of genes, and in doing so, we aim to make a profound difference in the lives of patients and their families. Join us in understanding the coordinated expression of the Syros team in fulfilling our mission.

https://www.syros.com/

XenaLives

09/29/20 8:04 AM

Post #22

Short interest:

Settlement Date Short Interest Percent Change Average Daily Share Volume Days to Cover

09/15/2020 3,704,007 2.20 396,560 9.34
08/31/2020 3,624,255 31.32 554,074 6.54
08/14/2020 2,759,900 (4.90) 201,768 13.68
07/31/2020 2,901,991 (1.32) 164,265 17.67
07/15/2020 2,940,745 (7.83) 261,889 11.23
06/30/2020 3,190,583 13.89 444,310 7.18
06/15/2020 2,801,353 (1.75) 283,038 9.90
05/29/2020 2,851,334 2.43 353,974 8.06
05/15/2020 2,783,765 2.57 328,963 8.46
04/30/2020 2,713,943 (4.19) 342,958 7.91
04/15/2020 2,832,539 19.36 231,033 12.26
03/31/2020 2,373,139 (5.19) 199,335 11.91
03/13/2020 2,502,936 7.87 354,033 7.07
02/28/2020 2,320,223 (4.81) 159,130 14.58
02/14/2020 2,437,464 (2.04) 134,058 18.18
01/31/2020 2,488,238 (0.12) 232,741 10.69
01/15/2020 2,491,195 6.48 292,650 8.51
12/31/2019 2,339,563 30.02 1,174,529 1.99
12/13/2019 1,799,433 (2.99) 182,069 9.88
11/29/2019 1,854,966 (15.81) 240,531 7.71
11/15/2019 2,203,310 (14.78) 323,602 6.81
10/31/2019 2,585,569 8.59 530,616 4.87
10/15/2019 2,381,117 3.45 138,734 17.16
09/30/2019 2,301,761 (1.62) 128,398 17.9

XenaLives

09/29/20 8:02 AM

Post #21

133% Institutional Ownership

https://fintel.io/so/us/syrs

XenaLives

09/29/20 8:00 AM

Post #20

June 12 $9.25 secondary

We have entered into a sales agreement with Cowen and Company, LLC, or Cowen, dated June 12, 2020, relating to the sale of shares of our common stock, $0.001 par value per share, offered by this prospectus. In accordance with the terms of the sales agreement, we may offer and sell shares of our common stock having an aggregate offering price of up to $75.0 million from time to time through Cowen, acting as our agent. Upon entry into the sales agreement, we terminated our prior at-the-market program pursuant to the original sales agreement, dated July 20, 2017, or the original agreement. At the time of such termination, approximately $19.6 million out of an aggregate of $50.0 million remained unsold under the original agreement.

Our common stock is listed on The Nasdaq Global Select Market under the symbol “SYRS.” The last reported sale price of our common stock on June 10, 2020 was $9.45 per share.

Sales of our common stock, if any, under this prospectus will be made at market prices by any method that is deemed an “at the market offering” as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended, or the Securities Act. Cowen is not required to sell any specific amount of securities, but will act as our sales agent using commercially reasonable efforts consistent with its normal trading and sales practices and applicable state and federal laws, rules and regulations and the rules of The Nasdaq Stock Market, LLC. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.

Cowen will be entitled to compensation at a commission rate equal to 3.0% of the gross sales price per share sold under the sales agreement. See “Plan of Distribution” beginning on page 17 for additional information regarding the compensation to be paid to Cowen. In connection with the sale of the common stock on our behalf, Cowen will be deemed to be an “underwriter” within the meaning of the Securities Act and the compensation of Cowen will be deemed to be underwriting commissions or discounts. We have also agreed to provide indemnification and contribution to Cowen with respect to certain liabilities, including liabilities under the Securities Act.

https://fintel.io/doc/sec-syrs-syros-pharmaceuticals-424b5-2020-june-23-18436-302

ClayTrader Free

12/20/19 5:27 PM

Post #19

* * $SYRS Video Chart 12-20-2019 * *

Link to Video - click here to watch the technical chart video

trustbutverifyit Free

12/20/19 10:22 AM

Post #18

Re: #17: @crudeoil24 - Very nice; you don't post much, but you

Crudeoil24- I spend a fair amount of time researching my next moves. I try to stay out of the fray on some of these boards. Lol

GLTY!

crudeoil24 PremiumMember

12/20/19 10:12 AM

Post #17

Re: #16: @trustbutverifyit - Crudeoil24- I still have a position in CRTX.

Very nice; you don't post much, but you certainly are on top of some powerhouse movers!

crude

trustbutverifyit Free

12/20/19 10:10 AM

Post #16

Re: #15: @crudeoil24 - Excellent move on SYRS. > Also are you

Crudeoil24- I still have a position in CRTX. I came across SYRS recently though and couldn’t resist buying in!

crudeoil24 PremiumMember

12/20/19 10:06 AM

Post #15

Re: #14: @trustbutverifyit - Picking up a few more shares today.

Excellent move on SYRS. > Also are you still holding CRTX? What a December upside run. SYRS will do same type of run!

trustbutverifyit Free

12/20/19 9:54 AM

Post #14

Picking up a few more shares today. With more good news, this is a no-brainer, IMO.

crudeoil24 PremiumMember

12/20/19 9:51 AM

Post #13

Re: #11: @hedge_fun - I sold at average $7.96. Looking for a......

University endowment funds, pension plans, mutual funds, and hedge funds loading... tutes are over 90% .

crudeoil24 PremiumMember

12/20/19 9:45 AM

Post #12

Re: #11: @hedge_fun - I sold at average $7.96. Looking for a......

SYRS & CRST > continuous upside moves!

hedge_fun

12/20/19 9:43 AM

Post #11

Re: #9: @crudeoil24 - 30M share trading float; OS is 42M shares.

I sold at average $7.96. Looking for a......

dip back into the $6’s.

We’ll see. But this remains on my watchlist long term.

crudeoil24 PremiumMember

12/20/19 9:41 AM

Post #10

Plenty of positive catalysts in play > So much news out this month. SYRS.

crudeoil24 PremiumMember

12/20/19 9:40 AM

Post #9

Re: #7: @hedge_fun - Even more good news this am.......

30M share trading float; OS is 42M shares.

crudeoil24 PremiumMember

12/20/19 9:24 AM

Post #8

Re: #6: @trustbutverifyit - I bought in when they announced the partnership

SYRS is a great $$$$$ opportunity.

hedge_fun

12/20/19 8:28 AM

Post #7

Re: #6: @trustbutverifyit - I bought in when they announced the partnership

Even more good news this am.......

Mr. Alles is the former Chairman and Chief Executive Officer of Celgene Corporation, now a subsidiary of Bristol-Myers Squibb Company (BMS). In his 16-year tenure at Celgene, Mr. Alles led the expansion of the company from a US-based organization with less than 500 employees into a global enterprise serving patients in more than 50 countries with 8,800 employees. He held a series of commercial and leadership roles of escalating responsibility, consistently delivering industry-leading financial performance. He led teams that completed several multibillion-dollar company or asset acquisitions, built a diverse suite of globally marketed medicines and a pipeline of high-potential therapeutics for cancer and serious inflammatory diseases, all of which ultimately led to the $74 billion acquisition of Celgene by BMS.

Merry Christmas and a Happy New Year!!!