2023 Anticipated Milestones, please?
I am fully and undeniably confident with their science, I have here long enough to know, this company will set the standard for Alzheimers and Parkinsons Disease, don't be fooled by the low volume, the shares are in very tight hand, including the insiders. Their communication sucks donkey balls, but their science will be proven and this stock will trade in the billions, 1-2 years. Furthermore, this stock is not to make a living of off day trading, this is something you hold for billions in market cap, once the science is proven.
This is going to run to triple dollars by end of the year at the maximum Easter next year. Here is why: Buntanetap is the only drug to attack multiple proteins simultaneously. This is paramount huge, not just huge. Watch what happens by fall this year.
Should be trading in the high teens before the conference. This stock and the market makers specifically do not like traders, trade with caution. Just a word of caution. If you plan on taking a big chunk, the trade will go against you immediately, just slowly accumulate. This stock is hands down triple dollar stock end of this year.
This is thing is real beauty.
Too much overreaction, swing and day traders killed it.
What? Link? nah, just a hunch?
Send me a link please
What was in presentations?
That is all that matters bud.
yes, very familiar with ATM's....note that she went to a powerhouse
I don't if you realized that shelf offering is not for immediate future, my thinking after the AD data is released sometime in the fall, that is not immediate secondary public offering, I expect news sometime next week, they will start selling on the upside to the tune of 2-3 million shares to add to the OS, which is still minor bump, still very small share structure compared to its peers, I am not concerned one bit. These guys have the science, but very poor with investor communication, this is not the first fumble, during the communications with the mass audience, whether it is deliberate or no, I don't know, but they are very poor communicating and getting their message across, but the science could be worth billion in the future, 2026 is going to be year for ANVS. Good luck
Needed to have a backstop....needed that no doubt, also saw that Maria exercised options @ 14 cents that expired in 2027....pretty open with shareholders....any feedback from April Fool's Day presentation? I caught the momentum turn pretty well, but overstayed, also saw and mentioned the overbought position, but failed to act...my bad.
Thanks for your input...actually this is exactly where I bought in. & I even mentioned that it was overbought, too...back to go for me!
I think we'll see if the CEO can succeed or fail here; my idea is that she is a good person & has spent good money last year ($500,000 @25) and has her eye on the target with shareholder respect with that....she certainly has a problem now if this presentation is a flop.
Also, noticed that she has a boatload of options, too....with very low strikes.
That was known 2 days ago that the report was on Saturday? Or sorry the conference ended on Saturfay
The 8k reports
Very courageous as usual!
450 enrollment should be enough, right?....1/3 in each enrollment (150)
noticed on 8K that 2month data so far
stock dropping from overbought condition
need to watch this more for today may or may not reflect the DSMB reasons
appreciate your comments
Stocktwits reports this morning that both ANVS presentations have been rescheduled for tomorrow, Saturday?
Reasons why PD data is delayed
Someone on Stocktwits called Annovis's IR and learned that:
- the Data and Safety Monitring Board (DSMB) was the responsible of the delay
- the IR person said DSMB is pondering whether or not Annovis should continue enrolling more patients for its ph3 PD trial
A- Data was horrible and the DSMB thinks it is better to stop here and saving patients' time.
B- Data was so good that the DSMB thinks current patient population is enough to demonstrate statistical significant efficacy, which will expedite the approval process.
Arguments supporting outcome B include:
- Positive and correlated feedback from ph2 PD patients with their being in the treatment arm.
- Noticeable improvement in PD symptoms (Maria mentioned writing speed).
- Enthusiam from the patient community in enrolling into the trial (Maria mentioned some centers had to stop recruiting because they reached their quotas).
On the valuation side:
- Company like Cerevel (CERE) has an enterprise value (EV) of $3.1B.
- CERE essentially has one phase 3 asset in PD and a three others in phase 2.
- Their lead drug candidate is just a better version of levodopa.
A quick and dirty valuation math gives us around $800M of value for this asset (simple division but in reality more as it is more advanced than the rest of the pipeline). Annovis's EV is only around $150M. If (when?) market recognizes buntanetap's potential, share price may reach $100+... on PD alone. Because if improvement is shown in PD, it is a confirmation of Maria's hypothesis for AD as well.
Thank you for those who took the time to read this and good luck.
Hello, Maria... good luck on today's presentation & tomorrow, too
MARIA L. MACCECCHINI, Ph.D.
Founder, President, CEO and Executive Board Member
Dr. Maccecchini founded Annovis in May 2008 to develop better therapeutics for Alzheimer’s, Parkinson’s and other neurodegenerative diseases. Was partner and director of two angel groups, Robin Hood Ventures and MidAtlantic Angel Group; Founder and CEO of Symphony Pharmaceuticals/Annovis a biotech company that sold in 2001 to Transgenomic; General Manager of Bachem Bioscience, the US subsidiary of Bachem AG, Switzerland and Head Molecular Biology Mallinckrodt; Dr. Maccecchini did one postdoc at Caltech and one at the Roche Institute of Immunology, her PhD in biochemistry is from the Biocenter of Basel with a two-year visiting fellowship at The Rockefeller University.
Details on the Company's two presentations are provided below.
Abstract Number: 3080
Title: Phase 3 Clinical Studies in Alzheimer's and Parkinson's Disease; Interim Analysis of the Parkinson's Clinical Study
Date: Thursday, March 30, 2023
Presenter: Cheng Fang, Ph.D.
Abstract Number: 3114
Title: Do Mouse Data Lie? For Buntanetap They Totally Predict Human Outcome
Date: Friday, March 31, 2023
Presenter: Maria Maccecchini, Ph.D
Data presentation coming out tomorrow.
ANVS is the next to go parabolic.
This trading base is very large, so it might just offer some news pretty soon.
The target I have is substantially higher, assuming a push above the September 2022 high.
I'm long and expecting it!.........but certainly have my share of errors....
I like the CEO, Maria Maccecchini very much and she is a shareholder owning stock!
Our govt may send billions to Ukraine
For fascist oligarch one world era to share and connive upon( blood money) while Americans die of terrible CNS disease which Blarcamesine could prevent..
Won’t go into the pure idiocy of giving healthy babies and pregnant women dangerous myocarditis creating experimental medicine while denying dying death sentenced dementia sufferers
safe experimental medicines like Blarcamesine , biovie, cassava, annovis, while they complete trials.
It’s the insanity of the bureau of the demented oligarchy of
Thought the snow would melt today so we could play gold tomorrow.
Made tee times
Called my friends
But although it’s 50 degrees
The ground is so cold from arctic blast
That all my plans for tomorrow which seemed reasonable based upon
temperature are for naught.
Didn’t try to lie, didn’t plan on not being able to play..but I will be working upon other aspects of life fulfillment until the snow melts..
The best laid plans of mice and men..
And that happened without people making money if I dont play golf tomorrow..
Thank God no one actively to destroy my financial value..other than democrats
“Every day thousands of patients die from aging-associated non-communicable diseases (AA-NCDs) that might have otherwise been given new treatments that current regulatory systems have no framework to allow them to try. AA-NCDs have been recognized by the United Nations as a “threat
to global development.” and a mandate has been set to improve the consequences of such diseases. Helping patients get access to new drugs is an imperative of the BCM.” Go to the site. Read about it. Sign the petition if you are so inclined. Best Choice Medicine makes sense for patients suffering from aging associated diseases such as AD. By the time a patient is diagnosed, the disease has done irreparable damage, and there is a short window of opportunity to stop the progression of the disease - especially for older patients. Why not allow establish a framework to allow these patients access to new drugs that may help them? Several drugs seem to candidates to help elderly patients with neurological disorders. These patients do not have the time to wait years for a promising drug to be approved according to the current regulatory systems.
I did, early this morning, I trade based on momentum and logic, mostly logic and logic tells me, I shouldn't follow the herd, I know ANSV is going to multiple billions early next year.
Just check it out, insiders own over 70% of the float
I am not going anywhere, have been loading this for months now. PXMD can run and do whatever it wants, this one has a legit run in it to triple dollars.
PXMD running like NERV SC-13 filing
Forget AVX*L and SNP*X, best of the best breed here. Nothing like ANV*S. Triple dollars coming here if you are patient.
The best of the best breed out there when it comes to Alzheimers and Parkinson's disease, nothing out there like this biotech. Will be in triple dollars when that data hits the wires.
7:36 am ET September 8, 2022
Annovis Bio, Inc. (NYSE:ANVS) ("Annovis" or the "Company"), a late-stage clinical drug platform company addressing neurodegenerative diseases, today released the following letter to stockholders from its Chief Executive Officer Dr. Maria Maccecchini.
Dear Fellow Stockholder,
Over the years we have been talking about the potential of buntanetap to treat more than Alzheimer's disease. In cell models, animal models and human clinical studies, we have seen that buntanetap works in numerous acute and chronic neurodegenerative conditions. I would like to take this opportunity to explain how one drug can be so broadly applicable.
Buntenatap works by inhibiting specific neurotoxic proteins such as amyloid precursor protein (APP), Tau, alpha-synuclein (aSYN), TAR DNA binding protein 43 (TDP-43), huntingtin (HTT) and prion protein. These proteins have normal functions but in their neurotoxic aggregating form, they impair axonal transport, slow synaptic transmission, cause inflammation, and ultimately, kill nerve cells, resulting in the loss of affected function in various neurodegenerative conditions.
The overexpression and aggregation of these proteins is caused by elevated levels of iron in the nerve cell. The mRNAs of neurotoxic aggregating proteins contain an iron response element (IRE) which binds to an iron regulatory protein called IRP1. At normal iron levels, translation occurs at appropriate physiological levels. When iron flows into the cell, the mRNAs are released and translated at higher rates by the ribosome. When massive iron flows in, the mRNAs remain unbound for as long as the iron is high and the proteins for these neurotoxic aggregating proteins are overexpressed. In this high iron situation, buntanetap binds to the atypical IRE-IRP1 complex and prevents the mRNA from being released and, therefore, from being translated and overexpressed.
Buntanetap is able to inhibit the translation of multiple neurotoxic proteins through this mechanism of action, and as a result has the potential to treat numerous acute and chronic neurodegenerative conditions that share this pathway. In mouse or rat models of Alzheimer's, Parkinson's, stroke, frontotemporal dementia, traumatic brain injury, glaucoma, and Down Syndrome, buntanetap has been shown to normalize the levels of these neurotoxic proteins and to restore function.
Most importantly, this has been demonstrated in human clinical trials. In our recent Phase 2 clinical trial in Alzheimer's disease and Parkinson's disease, treatment with buntanetap resulted in reduction of aggregating proteins and statistically significant improvement in motor function in Parkinson's disease patients and cognition in Alzheimer's disease patients.
AD mice, DS mice, stroke mice, TBI rats
Colonic motility, grip strength
PD mice, tau mice
P. Gingivalis mice, Covid mice
Cognition, memory, learning
Early AD patients
Attention, thinking speed
Early AD patients
Early PD patients
Early PD patients
Table 1: Summary of all animal and human study data.
We look forward to unlocking the full potential of buntanetap and addressing unmet needs across a range of acute and chronic neurological conditions.
Maria L. Maccecchini, Ph.D.,
Founder, President, CEO and Executive Board Member