Ponken...

A helpful, well informed assessment. Thanks.

AB-E-NORMAL day so far? No AVXL premarket trading/sales (+/-) Volume or nasty back & forth? HUH. ? So What?

How to prove CNS diseases failure root causes?
As someone who spent many years/decades engineering/testing and developing semiconductor devices I am amazed to see the basics in what REALLY causes-contributes-accelerates human CNS (systems) failure is not well understood-or proven.

https://www.sciencedirect.com/science/article/abs/pii/S0026271417304985

Up until the mid 60's semiconductor devices were a lab novelty w/so many problems which prevented full commercial volume and uses (stability-reliability being the biggest BLACK hole) . Imagine our world today w/o microprocessors or integrated ckts or even reliable diodes. There would be no WW communication systems or electronics wonders had the basic early failure physics mechanisms not been understood. (BTW those failure physics still exist in nature but we have since engineered ways to fix/prevent/control them through solid manufacturing controls) .

All of the basic failure mechanisms were wrung out by smart-hard working people at Bell Labs and in a few other places (MIT) WW once the mechanisms were proven. I find it curious that CNS medical systems are stuck w/no basic tool suite to work on/engineer the CNS issues after decades. WE are still beating Amyloid Plaques after 50+ years and getting no where.

The biggest breakthroughs in semiconductor physics happened when Dr. Connie Zerdt (sp?) at Bell labs introduced accelerated failure tools. No such tool suite exists in CNS tool box (yet) . Research in CNS failure mechanisms has consequently not figured out how to accelerate (speed up ) CNS brain failures in a lab. Consequently we/they wait years to study efficacy w/very little other than time, as a control. Find a way to accelerate CNS micro failures & root causes.

Find a way to accelerate brain shrinkage (if that is an important metric) . By doing accelerated testing we will easily get better (more predictable results) faster. The rate of progress in CNS root cause analysis is mid-evil...THX FDA. When key failure micro variables are understood then accelerated test modes will prove the root causes very quickly and then results will jump off the page. Bottom line, accelerated failure models/concepts are bullet proof.

As long as the current (time driven) investigation methods are used no high confidence processes (accelerated failure models) can be developed and no solutions will be produced. BTW, in semiconductor research we discovered that Ionic Contaminants, poor designs and sloppy manufacturing practices resulted in unstable devices w/high failure rates. These failure mechanisms also exist today all BP unless they are measured and controlled.

power walker[quote]1) The members of the Board know the plan and the strategy going forward; you nor anyone on this board knows that.
2) The Board members have seen the full results of all the trials. They agree in principle with 1).
3) They are well aware of TGD's short-comings. His management of 1) and 2) over-rides that concern.
4) Tom Skarpelos is not afraid to pull the plug on a floundering CEO (see Missling's predecessor, Cameron Durrant). He is still in Dr. Missling's corner.
5) Naysayers' success of scaring posters to sell 10K, 50K or 100K over a week's time, is a win for lower prices and its benefactors and indicates a drug's failure. Only, the world's drug agencies will decide a drug's pass or fail. IMO, 2-73 will pass![/quote]

Excellent post. Thank you , I needed that on this darker then normal day.

georgejji

Any thoughts on when and how these phony suites get dispositioned? TIA

https://ih.advfn.com/stock-market/NASDAQ/anavex-life-sciences-AVXL/stock-news/93662788/the-gross-law-firm-reminds-shareholders-of-a-lea

What quick and effective tools does AVXL staff have to counteract-prevent this daily SP beatdown ? Urgently request that tool suite be put to use. NOW.

Yes, today, Monday, April 15, 2024,
the stock market will be open.

Tomorrow, Tuesday, April 16, 2024, the stock market will be open.

4.4300
+0.13
(+3.14%)
Pre-Market: 8:51 AM EDT

4.4700
+0.17
(+4.07%)
Pre-Market: 8:45 AM EDT

Is WS open today as stated on goggle?

Xena

test...

PSA: Conclusion: Owning Anavex stock and getting older is not for sissies. Some days it seems like you can do one OR the other.

As an old friend of mine (W. Edwards Deming) would often say..."The first step in solving a problem is recognizing that one exists."

As an old friend of mine (W. Edwards Deming) would often say..."The first step in solving a problem is recognizing that one exists." .IMO, Dr. M. is very capable of doing what is needed to be done ... BUT, he just does not see what we(and others) see.

IMO, Dr. M sees AVXL as a leadership technology-scientific organization which is performing incredible positive technical work (he is right), continuously proving the science and the Med-truth. IMO, from his perspective, he is absolutely correct about that . AVXL is a world class CNS leadership highest technology firm. Sadly , the WS-BP world has a different set of metrics-values and time lines. One would think that after 50+ years of following-chasing the wrong thing w/FDA controls dictating good news vs not good news a better set of metrics would have evolved for defining value in CNS diseases. A lot of very smart people (WS-BP-other) have allowed themselves to get rat holed and are not able to see(recognize& value) AVXL as a solution. It is very sad but IMO, we are on the right train but it is seeen as not moving yet????.

"A little good news Today"?

We are sooooo fxng due...TURN IT UP ....

...TCLW...

https://www.anavex.com/_files/ugd/850d88_80ed72201c1f4173a87f87a09470aa46.pdf

Very impressive new package from AVXL staff...looks strong...WELL DONE

Boopka...You are EXACTLY CORRECT.

Talon38

https://www.medicalnewstoday.com/articles/researchers-identify-novel-genetic-variants-alzheimers

This is the new knowledge path consistent with the one AVXL has been on and demonstrated. Very helpful in that it begins the reveal the pathetic -simplistic (amyloid-cluster) old simplistic thinking of the FDA along expensive-unhelpful dart board they have fostered-funded for 50+ years of CNS-AD darkness.

Lets hope that something new finally sticks as (IMO), "AVXL --CNS --SYSTEMS (S1R) THINKING", begins to be more fully understood and funded .