DarthYoda

Followers	135
Posts	13,914
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Alias Born	09/05/2013

DarthYoda

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DarthYoda

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DarthYoda

02/19/24 3:03 AM

Post #5951 on Pfizer Inc (PFE)

Coincidence pfe?
https://trends.google.com/trends/explore?date=all&geo=US&q=%2Fg%2F121kwpxw&hl=en-US

DarthYoda

02/19/24 1:49 AM

Post #21971 on Charlotte's Web Holdings Inc (CWBHF)

The "Autism" trend chart is even more shocking than the earlier chart for ASD, "Autism Spectrum Disorder"...
Does anyone have any politically correct explanations for this chart?...
"Autism"
https://trends.google.com/trends/explore?date=all&geo=US&q=%2Fg%2F121kwpxw&hl=en-US

DarthYoda

02/17/24 6:10 AM

Post #21963 on Charlotte's Web Holdings Inc (CWBHF)

That ASD trend chart shocked me. It should be on the news.

DarthYoda

02/17/24 6:09 AM

Post #21962 on Charlotte's Web Holdings Inc (CWBHF)

OMG...ASD...https://trends.google.com/trends/explore?date=all&geo=US&q=%2Fm%2F02p3f5&hl=en-US

DarthYoda

02/17/24 5:56 AM

Post #21957 on Charlotte's Web Holdings Inc (CWBHF)

"Could an NLRP3 inhibitor be the one drug to conquer common diseases?":
February 17, 2020
https://cen.acs.org/pharmaceuticals/drug-discovery/Could-an-NLRP3-inhibitor-be-the-one-drug-to-conquer-common-diseases/98/i7

DarthYoda

02/17/24 5:55 AM

Post #21956 on Charlotte's Web Holdings Inc (CWBHF)

CBD's range of powers should make more sense now...
"Pharma Looks to Inflammasome Inhibitors as All-Around Therapies":
Apr 1, 2021
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.

https://www.the-scientist.com/pharma-looks-to-inflammasome-inhibitors-as-all-around-therapies-68582
"...finding drugs to selectively stop NLRP3 will be difficult."
https://cen.acs.org/pharmaceuticals/drug-discovery/Could-an-NLRP3-inhibitor-be-the-one-drug-to-conquer-common-diseases/98/i7
"...we emphasize the capacity of cannabidiol to suppress inflammation by blocking the NLRP3 signaling pathway..."
https://link.springer.com/article/10.1007/s00011-023-01831-y

DarthYoda

02/16/24 3:16 PM

Post #21943 on Charlotte's Web Holdings Inc (CWBHF)

Hmmm...Pericarditis...https://trends.google.com/trends/explore?date=all&geo=US&q=%2Fm%2F032snl&hl=en-US

DarthYoda

02/16/24 2:43 PM

Post #21942 on Charlotte's Web Holdings Inc (CWBHF)

Recreate+MLB+PLL website looking good...
https://recreateyou.com/mlb
https://recreateyou.com/pll

DarthYoda

02/16/24 2:38 PM

Post #21941 on Charlotte's Web Holdings Inc (CWBHF)

"Farmers, businesses push back on Florida Republicans' efforts to restrict THC products"
Feb 16, 2024
https://www.orlandoweekly.com/cannabis/farmers-businesses-push-back-on-florida-republicans-efforts-to-restrict-thc-products-36201768

DarthYoda

02/16/24 2:27 PM

Post #5943 on Pfizer Inc (PFE)

Ok fine...

DarthYoda

02/16/24 1:59 PM

Post #21940 on Charlotte's Web Holdings Inc (CWBHF)

Same goes for ASD..."Multiple inflammasome complexes are activated in autistic spectrum disorders":
2016 Mar 12

Abstract
Background: Inflammasomes are multimeric protein platforms involved in the regulation of inflammatory responses whose activity results in the production of proinflammatory cytokines. Because neuroinflammation is observed in autistic spectrum disorders (ASD), a neurologic condition of childhood resulting in a complex behavioural impairment, we analyzed the inflammasomes activity in ASD. Additionally we verified whether alterations of the gastrointestinal (GI) barriers might play a role in inflammasomes activation.

Methods: The activity of the inflammasomes, the concentration of the inflammasomes-derived proinflammatory cytokines interleukin (IL)-1ß and IL-18, and serum parameters of GI damage were analyzed in 25 ASD children, 23 healthy siblings (HS) and 30 unrelated age-matched healthy controls (HC).

Results: A significant upregulation of the AIM2 and the NLRP3 inflammasomes and an increased production of IL-1ß and IL-18 that was associated with a consistent reduction of IL-33, an anti inflammation cytokine were observed in ASD alone. Notably, in a possible immune-mediated attempt to dampen inflammation, IL-37, a suppressor of innate inflammatory responses, was significantly augmented in these same children. Finally, intestinal fatty acid binding protein (IFABP), an index of altered GI permeability, was significantly increased in serum of ASD and HS.

Conclusions: These results show that the inflammasomes are activated in ASD and shed light on the molecular mechanisms responsible for ASD-associated neuroinflammation. The observation that GI alterations could be present as well in ASD offers a possible link between such alterations and neuroinflammation. Therapeutic strategies targeting inflammasome activation could be useful in ASD.

https://pubmed.ncbi.nlm.nih.gov/26979869/

DarthYoda

02/16/24 1:30 PM

Post #21939 on Charlotte's Web Holdings Inc (CWBHF)

"Inflammasomes"...Looks like we're on to something here...CBD/Hemp extract has shown promise for all of these conditions as well...
"...Inflammasome Activation Is Pathogenic in Multiple Neurological Diseases":
Feb. 14, 2024

This article provides increasing evidence that activation of several types of inflammasomes and extracellular ASC specks contribute to the development and progression of multiple neurological diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), epilepsy, traumatic brain injury (TBI), and stroke.

Many neurological conditions involve an underlying chronic inflammasome-mediated inflammatory process that worsens the trajectory of these conditions.
Beyond NLRP3, evidence suggests that other inflammasomes, including but not restricted to NLRP1, NLRC4, and AIM2, and their downstream effectors contribute to neuropathology in AD, PD, ALS, MS, stroke, epilepsy, and TBI.

https://markets.businessinsider.com/news/stocks/zyversa-therapeutics-highlights-review-article-substantiating-that-inflammasome-activation-is-pathogenic-in-multiple-neurological-diseases-1033066259

DarthYoda

02/16/24 11:59 AM

Post #21938 on Charlotte's Web Holdings Inc (CWBHF)

Re: Social benefit projects...I was happy with what these guys were doing with Realm of Caring and thought they would do more together. Maybe the FDA would pick on them for it now. I don't know, but I do think CW should do all, most, or at least some of their social benefit work through RoC. It made more sense IMO.

DarthYoda

02/16/24 10:31 AM

Post #5941 on Pfizer Inc (PFE)

The jabs could use a sprinkle of CBD to tone down the pericarditis a bit...
"Cannabidiol Formulation Granted Orphan Drug Designation for Pericarditis"
February 15, 2024
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173861656

DarthYoda

02/16/24 10:26 AM

Post #21937 on Charlotte's Web Holdings Inc (CWBHF)

Well, whaddya know. FDA grants orphan drug status for a CBD formulation to protect from a very popular "vaccine" side effect, based on the NLRP3 inflammasome I posted about a couple weeks ago..."Cannabidiol Formulation Granted Orphan Drug Designation for Pericarditis":
February 15, 2024

The Food and Drug Administration (FDA) has granted Orphan Drug designation to CardiolRx™ (cannabidiol oral solution) for the treatment of recurrent pericarditis. The NLRP3 inflammasome is known to play a key role in the inflammation and fibrosis associated with pericarditis.

https://www.empr.com/home/news/drugs-in-the-pipeline/cannabidiol-formulation-granted-orphan-drug-designation-for-pericarditis/
"The NLRP3 inflammasome: a vital player in inflammation and mediating the anti-inflammatory effect of CBD":
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173751754

DarthYoda

02/16/24 2:29 AM

Post #21933 on Charlotte's Web Holdings Inc (CWBHF)

"Why to consider botanical drug INDs?":

Dietary supplements:
-Cannot make medical claims: dietary supplements are restricted from making medical claims, limiting their market positioning.
-Low market barrier and high competition
-High product development cost leading to low-profit margin
What a botanical drug IND provides:
-A botanical drug IND allows you to make distinct medical claims, creating a market barrier
-Botanical drugs are not required to show specific active ingredients.
-Botanical drugs can be developed from a single plant or a blend of multiple plants, providing flexibility in product development.
-No need to describe the mechanism of action
-The success rate is significantly higher when developing known safe and effective botanical products compared to synthesizing or purifying new chemical molecules.
-The concept of botanical drugs primarily exists within the FDA regulatory framework and is specific to the process of regulatory filing and approval. Once botanical products receive approval as prescription drugs and enter the market, there is no perceived difference from chemical drugs.

https://www.botanicaldrug.org/service

DarthYoda

02/16/24 2:25 AM

Post #21932 on Charlotte's Web Holdings Inc (CWBHF)

"Botanical Drug Development Guidance for Industry":
https://www.fda.gov/media/93113/download

DarthYoda

02/16/24 2:14 AM

Post #21931 on Charlotte's Web Holdings Inc (CWBHF)

https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/frequently-asked-questions-botanical-drug-product-development

DarthYoda

02/16/24 12:29 AM

Post #21930 on Charlotte's Web Holdings Inc (CWBHF)

Fwiw, I was happy to see the CEO of Ben and Jerry's in the picture at all as I sent the company an email suggesting they work with Ben and Jerry's years ago. I meant something more like a business venture though and not just another board member as I think this company has had way too many execs and board members passing through already. They need permanent long term people who are dedicated to the bigger long term goals. Hopefully, something bigger can come out of them working together. I saw he took no shares when he joined the Board, which is different than usual...
https://www.otcmarkets.com/filing/html?id=17247304&guid=5Qd-kKhdNG6Vvhh

DarthYoda

02/16/24 12:17 AM

Post #21929 on Charlotte's Web Holdings Inc (CWBHF)

I am aware of the very real effect of full spectrum hemp extract on Autism and I think that should be one of the best and most widespread uses for it. I am still waiting for an autistic spectrum relative's federal legal situation(drug tests) to finish up after many years so they can try it for the first time. I think it could be a life changer for them. My pessimism here comes only from the business side, not the science side at all.
I also am not a fan of corporate America's version of "social equity". "Get woke, go broke" is a well known saying now for a reason. I'd like to see CW drop the B corp designation, donate to an appropriate charity when it makes sense, and stop giving away money, products, and company IP based on sexual preference and skin color. Corporate wokeness is just racism and bigotry and was supposed to be illegal in America. I grew up in a genuinely multicutural way, in one of the most multicultural neighborhoods in America, with friends and girlfriends of all races, so the fake woke shit is just nails on a chalk board to me. Gay people are not victims who deserve free money just because they are gay and it's not ok to give away shareholder IP to farmers just because they are Black farmers and not White or Asian farmers.
I honestly can't believe I've found my self explaining this stuff to adults who run million or billion dollar corporations in 2024, but here we are, that's our country now, a confused cult. I never expected Big Tobacco to be involved here, and am surprised I stuck around after they showed up. However, if they can stick to CW's original mission, I am all for their redemption. This company's social goals were originally supposed to be about disabled children and adults who lacked access to the plant. That is a mission I can respect. Those people really do need the products and support. I wont be lead astray like the kids today though into cheering for a social philosophy that I know is the exact opposite direction of where the country was headed 15-25 years ago, when we were much more on the right track. I want to see the original mission succeed and will criticize deviation from that, especially when it is morally bankrupt and detrimental to shareholders.

DarthYoda

02/15/24 4:52 PM

Post #21926 on Charlotte's Web Holdings Inc (CWBHF)

???...

Select symbol
Canada
CWEB:TORTSX
United States
CWBHF:QXEOTCQX International
Germany
6CW:FRAFrankfurt Stock Exchange
6CW:DEUGerman Composite
6CW:DUSDusseldorf Stock Exchange
6CW:BERBerlin Stock Exchange
6CW:MUNMunich Stock Exchange
6CW:STUStuttgart Stock Exchange

https://markets.ft.com/data/equities/tearsheet/summary?s=6CW:BER

DarthYoda

02/15/24 3:12 PM

Post #21924 on Charlotte's Web Holdings Inc (CWBHF)

https://defloria.bio/

On April 6, 2023, the Company announced the formation of DeFloria LLC, a Delaware limited liability company (“DeFloria”) with AJNA BioSciences PBC (“AJNA”), and a subsidiary of British American Tobacco PLC (LSE: BATS and NYSE: BTI) (“BAT”). BAT holds a 100% equity interest in the preferred units of DeFloria and the Company and AJNA each hold 50% of the joint venture’s voting common units. The Company’s contribution to the joint venture was a license permitting the use of certain proprietary hemp intellectual properties, including clinical and consumer data.

Effective February 12, 2024, the Company and DeFloria entered into a Master Services Agreement (“Services Agreement”) pursuant to which the Company will be compensated for the provision of certain services to DeFloria. The services include assistance with Standard Operating Procedures (SOPs), product testing, stability testing, lab liaison, sampling of product, sample submission, data review, Out of Specification (OOS) evaluation, BMCS, document creation, documentation transition project, BR review, spec/RF creation, clinical trials advisory, OOS and risk mitigation testing.

https://www.otcmarkets.com/filing/html?id=17276969&guid=8dd-keHwt05eJth

DarthYoda

02/15/24 3:06 PM

Post #21923 on Charlotte's Web Holdings Inc (CWBHF)

New 8-K...not sure why the big drop...
https://www.otcmarkets.com/filing/html?id=17276969&guid=8dd-keHwt05eJth

DarthYoda

02/15/24 12:09 PM

Post #53272 on Bitcoin (BTCUSD)

"Black⬛️Rock and Fidelity Continue to Lead Spot BTC ETF Inflows"...
4 hours ago
https://www.coinspeaker.com/bitcoin-52k-spot-btc-etf-inflows/

Maybe Satoshi=Black⬛️Rock.

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173807560

DarthYoda

02/15/24 10:23 AM

Post #21922 on Charlotte's Web Holdings Inc (CWBHF)

Couldn't resist...
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173852245
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173852354

DarthYoda

02/15/24 10:17 AM

Post #5 on Braze Inc (BRZE)

You got it MG. Apparently, it is kind of old news, but it's new to me. Venmo customer service was shocked about it when I asked them, as if they had never heard of it before. They said they would email back a response and confirmation of our phone discussion and never got back to me at all...what to do next???...
"Why Venmo sent my personal info – and yours – to Braze":
Feb 24, 2020
https://www.usatoday.com/story/tech/2020/02/24/why-okcupid-venmo-grindr-send-braze-personal-info/4845495002/

DarthYoda

02/15/24 10:04 AM

Post #5940 on Pfizer Inc (PFE)

Lyrica vs CBD for PTSD...
"CBD=#9 most effective"
"Lyrica=#62 most effective"
https://www.stuffthatworks.health/complex-post-traumatic-stress-disorder-c-ptsd/compare-treatments/cannabidiol-vs-pregabalin

DarthYoda

02/15/24 9:59 AM

Post #5939 on Pfizer Inc (PFE)

Lyrica(Pregabalin) vs Cannabidiol(CBD) for Epilepsy...
Lyrica="#27 Most Tried, #24 Most Effective, #15 Most Detrimental"
"REPORTED SIDE EFFECTS
10%Weight gain
6%Drowsiness
6%Fatigue"
https://www.stuffthatworks.health/epilepsy/treatments/pregabalin
CBD="#13 Most Tried, #14 Most Effective"
"REPORTED SIDE EFFECTS
2%Drowsiness
1%Fatigue
0.7%Weight gain"
https://www.stuffthatworks.health/epilepsy/treatments/cannabidiol

DarthYoda

02/14/24 2:42 PM

Post #3733 on Ethereum (ETHUSD)

Yeah crazy times we live in.

DarthYoda

02/14/24 2:21 PM

Post #3 on Braze Inc (BRZE)

Fwiw, other trackers in other financial apps like CashApp have also been blocked. Bugsnag and Optimizely are two other examples. Braze however was trying to get more specific info like first name, last name, gps coordinates, email address, city, and like 20 more categories.

DarthYoda

02/14/24 2:18 PM

Post #2 on Braze Inc (BRZE)

I caught this company extracting personally identifying info from my phone through Venmo this past weekend. I had never heard of Braze until I saw 39 tracking attempts of theirs blocked from my phone. I'd like to uninstall Venmo now, but can't just yet. It just doesn't seem appropriate for a financial/banking app.
https://www.braze.com/

DarthYoda

02/14/24 1:52 AM

Post #3730 on Ethereum (ETHUSD)

SEC, CCP, ETH...and gary...
"Former Ethereum Advisor Steven Nerayoff Accuses SEC Chair of Undisclosed ETH Involvement":
February 13, 2024

Additionally, reports from TruthLabs indicate the CCP may control over 66.6% of the ETH supply.

https://cryptonews.com/news/former-ethereum-advisor-steven-nerayoff-accuses-sec-chair-of-undisclosed-eth-involvement.htm

DarthYoda

02/13/24 2:01 PM

Post #5934 on Pfizer Inc (PFE)

"COVID VAX TRIALS ON KIDS WICKED PFIZER, CDC, FDA":
https://www.bitchute.com/video/Xn4d0kCNIMK7/

DarthYoda

02/12/24 5:35 PM

Post #21919 on Charlotte's Web Holdings Inc (CWBHF)

Well, this company has destroyed my long term interest in seeing hemp become a legitimate thriving industry. I wont be posting here anymore and am moving on to spend my time on something other than hoping for the government to fix the purposely broken hemp industry or for this company to do anything at all in the interest of its shareholders. Good luck to you guys.

DarthYoda

02/12/24 4:15 PM

Post #5932 on Pfizer Inc (PFE)

Listen closely...
"NEVER FORGET WHAT THIS BAYER EXECUTIVE SAID":
https://www.bitchute.com/video/94EFb4kxC1WQ/

DarthYoda

02/11/24 9:28 AM

Post #5928 on Pfizer Inc (PFE)

Ha! Thanks IH. Your very kind words are much appreciated. I missed you guys too. We can consecrate the reunion with a 3 year compilation of elite athletes collapsing...
"3 YEARS OF ELITE ATHLETES COLLAPSING - 2021 TO 2024"
https://www.bitchute.com/video/QFxIN4et0ibx/