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Vaxart, Inc. (VXRT)

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The proprietary VAAST™ oral vaccine platform uses state-of-the-art recombinant technology that allows modular creation of a wide range of vaccines.


      Our Proprietary VAAST™ Platform

Vaxart uses a specific virus called adenovirus type 5 (Ad5) as part of its novel VAAST™ platform to help train our immune system to recognize and defeat dangerous invading pathogens. Vaxart recombinantly removes the DNA Ad5 uses for viral replication, so the virus cannot make copies of itself.
Vaxart then uses the disabled Ad5 virus as a delivery system, or “vector,” to carry the genes coding for the “antigen,” a component of the target virus that is known to generate a protective immune response, and the “adjuvant,” a molecule that stimulates the innate immune system. The Ad5 vector delivers these two genes to the epithelial cells lining the mucosa of the small bowel.
When the altered Ad5 virus enters a cell and delivers the genes for the antigen and the adjuvant, the genes are expressed, and the cell manufactures the vaccine antigen for the immune system to recognize, as well as the adjuvant that stimulates the immune system to mount a targeted response against the vaccine antigen.
These two molecules “teach” the immune system to recognize the antigen, a specific component of the pathogen. The next time the same antigen appears in the body, as part of a new infection, the immune system is prepared to mount a rapid and overwhelming response.
VAAST™ = Vector-Adjuvant-Antigen Standardized Technology


   Modular Vaccine Creation

The Vaxart tablet vaccine is composed of three basic elements:
The vector: the Ad5 delivery vehicle that carries the DNA “payload” to the gut
The antigen: the pathogen protein designed to trigger the targeted immune response
The adjuvant: a “booster” molecule that stimulates and adds to the immune response
By using the same vector, but with different antigens, Vaxart has designed a modular, scalable and standardized approach to vaccine development.

With this system, we can support the rapid development of numerous vaccines against established targets, as well as against new and emerging pathogens.
We can achieve important synergies – we can use the same manufacturing processes for all of our vaccines.


Current Pipeline


Three Phase 1 studies of Vaxart’s norovirus tablet vaccine indicated it is well tolerated and generated systemic and local immune responses that are both robust and persistent. The most recent Bivalent Phase 1b study demonstrated subjects obtained robust responses to both the mucosal and the systemic immune system.

Influenza is a worldwide infectious disease, with symptoms that range from mild to life-threatening and sometimes resulting in death. Serious illness occurs not only in susceptible populations, such as older adults, but also in the general population when unique strains of influenza arise.

Respiratory Syncytial Virus (RSV)
Respiratory syncytial virus (RSV) is increasingly recognized as an important cause of respiratory infection. While RSV infections can occur at any age, the elderly and those immunocompromised and living with underlying cardiopulmonary disease are particularly vulnerable.

Human Papillomavirus (HPV)
HPV is a group of more than 100 related DNA viruses that have the ability to infect the skin or mucous membranes. HPV is the most common sexually transmitted virus in the U.S. and infection is very prevalent following the onset of sexual activity. Vaxart is targeting HPV infection that causes cervical dysplasia and cancer due to HPV 16 and 18.


Vaxart’s COVID-19 Vaccine Selected
for the U.S. Government’s Operation Warp Speed

June 26, 2020 at 8:00 AM EDT

OWS to Test First Oral COVID-19 Vaccine in Non-Human Primates

SOUTH SAN FRANCISCO, Calif., June 26, 2020 (GLOBE NEWSWIRE) -- Vaxart, Inc., a clinical-stage biotechnology company developing oral vaccines that are administered by tablet rather than by injection, today announced that its oral COVID-19 vaccine has been selected to participate in a non-human primate (NHP) challenge study, organized and funded by Operation Warp Speed, a new national program aiming to provide substantial quantities of safe, effective vaccine for Americans by January 2021.

The study is designed to demonstrate the efficacy of Vaxart’s oral COVID-19 vaccine candidate.

“We are very pleased to be one of the few companies selected by Operation Warp Speed, and that ours is the only oral vaccine being evaluated.  SARS-CoV-2, the coronavirus that causes COVID-19, is primarily transmitted by viral particles that enter through the mucosa - nose, mouth or eyes - strongly suggesting that mucosal immunity could serve as the first line of defense,” said Andrei Floroiu, Chief Executive Officer of Vaxart Inc.  “In addition, our vaccine is a room temperature-stable tablet, an enormous logistical advantage in large vaccination campaigns.”

Vaxart Announces IND Filed for COVID-19 Vaccine

August 10, 2020 at 8:00 AM EDT

SOUTH SAN FRANCISCO, Calif., Aug. 10, 2020 (GLOBE NEWSWIRE) -- Vaxart, Inc., a clinical-stage biotechnology company developing oral recombinant vaccines that are administered by tablet rather than by injection, today announced that its COVID-19 Investigational New Drug (IND) application has been filed with the US Food and Drug Administration (FDA).

“We are very excited to reach this important milestone in advancing our oral COVID-19 vaccine candidate towards the clinic,” said Andrei Floroiu, chief executive officer of Vaxart. “We expect our upcoming Phase I study to generate data that will further differentiate our oral vaccine from injectable vaccines by substantiating the importance of activating both systemic and mucosal immunity in protecting against COVID-19.  We believe that this mechanistic benefit combined with the significant advantages of oral administration to the patient while eliminating the need for cold chain distribution, could make our COVID-19 vaccine an ideal candidate for successful mass vaccination campaigns globally.”

“Filing the IND is the first major step of many we are taking to advance our oral vaccine in the prevention of COVID-19,” said Sean Tucker, Ph.D., chief scientific officer of Vaxart. “We are excited to be moving this project toward clinical trials, and potentially demonstrating similarly potent mucosal and systemic immune responses like we have seen with our other vaccine candidates using the same oral tablet vaccine platform.”

Emergent BioSolutions Signs Development and Manufacturing Agreement
with Vaxart for their Experimental Oral Vaccine Candidate for Coronavirus Disease

GAITHERSBURG, Md., March 18, 2020 (GLOBE NEWSWIRE) -- Emergent BioSolutions Inc. (NYSE:EBS) announced today that it has entered into an agreement with Vaxart, Inc. (Nasdaq: VXRT), a clinical-stage biotechnology company, whereby Emergent has agreed to utilize its molecule-to-market contract development and manufacturing (CDMO) services to develop and manufacture Vaxart’s experimental oral vaccine candidate for coronavirus disease (COVID-19). Development services will begin immediately, and upon Vaxart’s election, Emergent agrees to produce clinical material expected to enable Vaxart to initiate a Phase 1 clinical study anticipated early in the second half of 2020. Vaxart’s oral recombinant vaccine candidate is based on its proprietary VAAST™ platform.



VXRT Investor Relations

F.D.A. great read KindredBio Partners with Vaxart for COVID-19 Oral Vaccine
October 9, 2020


$VXRT THEN 1. Oral formulations vs Liquid inoculations
[remember $KIN has partnered wit $VXRT]

1. Oral formulations make for easier storage and transport
When most people think of vaccines, they think of a syringe filled with liquid which is administered by a healthcare worker into the muscles or veins of the patient. 

In contrast, Vaxart's technology platform produces oral tablets containing the equivalent active components. 

This may seem like a minor distinction, 
but it's actually a critical factor that works strongly to Vaxart's advantage when it comes to currying favor with doctors and other providers.

Liquid inoculations typically require refrigeration during manufacturing, shipping, and storage at the point of use. 

If they aren't consistently kept at the correct temperature, their efficacy may drop, or they may spoil completely. 

This means that traditional liquid vaccines imply a substantial logistical burden on healthcare systems, 
as well as their suppliers, as a result of the additional refrigeration hardware and energy expenditures required.

Vaxart's tablets are stable at room temperature, however, 
so healthcare systems won't need to spend nearly as much to transport or store its coronavirus prophylactic, 
and the risk of spoilage is much low

2. Tablets don't require any consumables to administer
When patients get an inoculation in tablet form, there's no need

for the clinic that distributed it to purchase additional disposable syringes, sterilizing swabs, bandages, or even gloves. 

As a bonus, after the patient has taken the vaccine, clinics won't
need to pay for additional biohazard trash removal services to dispose of the used materials. 

Thanks to the sum of these savings, healthcare systems won't need to spend as much to administer Vaxart's candidate as they might with a traditional liquid inoculation, 
enabling them to vaccinate more patients than they could otherwise.

If these savings seem like they might be trivial, consider that an effective coronavirus prophylactic program would need to be deployed 
to about 3 billion people globally, 

which could easily create shortages and price spikes for the basic healthcare materials or services required for traditional liquid vaccinations.

3. Less risky self-administration
You've probably taken pills without a doctor or nurse standing at 
your side to supervise,

 but it's unlikely that you've ever prepared and self-injected a vaccination on your own. 

With an oral tablet, Vaxart hopes that patients will have the freedom 
to vaccinate themselves in the safety of their homes. 

This would be particularly advantageous because it would nullify the risk of patients getting infected in crowded clinics while waiting for their turn to be inoculated.

Vaxart's inoculations win via superior logistics, but oral vaccines aren't for everyone
Vaxart's shelf-stable, syringe-free, and easy-to-deploy prophylactic tablets would thus be popular among clinicians around the world thanks to their lower costs, 

and savvy investors should recognize that these advantages could be decisive for future earnings. 

However, there is one reason why doctors in underdeveloped regions might not favor Vaxart's candidate. 

While the scientific consensus is still forming, 
it may be the case that malnutrition makes oral vaccination less effective compared with intramuscular vaccination, especially in children. 

Therefore, clinics in areas with low food security might opt for a traditional formulation instead of Vaxart's solution.

Even with this potential disadvantage, I think that the vaccine's logistical strengths -- should it be approved 
-- will give the company an enduring advantage over the competition. 

Time will tell whether Vaxart's coronavirus candidate can live up 
to the necessary medical standards. In the meantime, look for the company's phase 1 clinical trial to start later in the summer.

Alex Carchidi has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. 

The Motley Fool has a disclosure policy.





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VXRT News: Vaxart Announces the Publication of Studies in the Peer-Reviewed Journal Science Translational Medicine That Suggest Mucosal Immunization Could Decrease SARS-CoV-2 Transmission 05/19/2022 04:30:00 AM
VXRT News: Vaxart (VXRT) Receives a Hold from B.Riley Financial 05/19/2022 03:37:38 AM
VXRT News: Brookline Capital Markets Thinks Vaxart’s Stock is Going to Recover 05/13/2022 01:15:26 PM
VXRT News: Current Report Filing (8-k) 05/11/2022 01:28:43 PM
VXRT News: Current Report Filing (8-k) 05/10/2022 02:01:54 AM
#5897  Sticky Note Let’s put into perspective the VXRT-State Street, BlackRock visionary2k 02/12/21 08:30:53 AM
#5700  Sticky Note $VXRT & PARTNER $KIN VXRT Investor Relations mick 02/02/21 03:44:29 PM
#6152   No to all questions. conix 05/06/22 02:33:33 PM
#6151   Hey Conix, are you on Stocktwits by any YJ4LIFE 05/06/22 11:13:42 AM
#6150   VXRT Vaxart Inc mick 05/02/22 10:24:20 AM
#6149   I know :-) Tamtam 05/02/22 02:03:22 AM
#6148   https://www.otcmarkets.com/stock/VXRT mick 05/01/22 07:45:49 PM
#6147   $VAXART ah favorite mick 05/01/22 07:45:09 PM
#6146   Thanks Mick Tamtam 05/01/22 05:14:04 PM
#6145   Additional Proxy Soliciting Materials (definitive) (defa14a) • Edgar mick 05/01/22 03:34:52 PM
#6144   Vaxart Inc (VXRT) mick 05/01/22 03:34:29 PM
#6143   Vaxart Inc (VXRT) Tamtam 04/03/22 06:15:14 AM
#6142   Vaxart Inc (VXRT) mick 03/12/22 03:12:51 PM
#6141   Vaxart Inc (VXRT) Tamtam 02/25/22 02:42:56 AM
#6140   Hunter Biden’s father has recently begun talking about Reyeton 02/06/22 07:58:21 PM
#6139   Vaxart Inc (VXRT) mick 02/06/22 05:58:38 PM
#6138   Vaxart Inc (VXRT) Tamtam 02/04/22 05:07:10 PM
#6129   STOPPING TRANSMISSION. Stops Covid 19 by stopping Chuck8032 01/11/22 09:31:16 AM
#6124   Nice rise today Tamtam 01/03/22 05:55:44 PM
#6123   https://www.otcmarkets.com/stock/VXRT mick 01/02/22 06:29:22 PM
#6122   Piiiiilllllls $$$$$$ WolfOfGrnStreet 12/22/21 09:45:35 PM
#6121   $$$ WolfOfGrnStreet 12/19/21 07:30:09 PM
#6119   Vaxart to Test Cross-Reactivity of its COVID-19 Tamtam 12/17/21 08:08:16 PM
#6118   https://newsxpres.com/t-cells-might-be-our-bodies-best-shot-against-omicron/ Reyeton 12/16/21 06:22:22 AM
#6117   https://www.otcmarkets.com/stock/VXRT mick 12/11/21 06:39:36 PM
#6116   Statement of Changes in Beneficial Ownership Tamtam 12/02/21 06:13:17 PM
#6115   Somebody better wake Miami Gent up ! 7Bullet7 11/29/21 08:05:13 AM
#6114   Betting my biscuits on it.. JackAskSlap 11/26/21 08:17:40 AM
#6113   Vaxart oral flu vaccine offers greater protection Tamtam 11/22/21 06:09:44 PM
#6112   Vaxart Inc (VXRT) mick 11/07/21 12:31:26 PM
#6111   Chart is looking promising imo Tamtam 11/03/21 07:42:25 AM
#6110   New Duke University-led Study Shows That Vaxart's Tamtam 10/07/21 07:54:32 PM
#6109   Wow 10 % up after hours Tamtam 10/07/21 07:53:58 PM
#6108   seems merck's drug may have 57_2001 10/05/21 03:20:37 PM
#6107   We’ll get there Tamtam 10/03/21 06:47:58 AM
#6106   It loses "uniqueness," though, and Merck is far trader59 10/01/21 03:16:36 PM
#6105   That pill reportedly treats an individual that already Obtuse Eye 10/01/21 03:08:27 PM
#6104   Another pill seems to have taken the spotlight: trader59 10/01/21 08:03:40 AM
#6103   This thing looks like it's trying to get rtrstock 09/27/21 12:25:16 PM
#6102   Vaxart Inc (VXRT) mick 09/22/21 11:34:55 PM
#6101   Your close to your exit point. Good luck. pennysoldier 09/21/21 07:50:17 PM
#6100   Well, I'm still waiting to go above 9.40 rtrstock 09/21/21 05:46:10 PM
#6099   Earlier this year, it went to $24 or pennysoldier 09/20/21 12:10:07 AM
#6098   Why isn't this trading higher? rtrstock 09/18/21 11:04:38 AM
#6097   VXRT 8.64 ? -0.25 (-2.81%) Tamtam 09/04/21 06:06:58 AM
#6096   Vaxart Inc (VXRT) Tamtam 08/23/21 05:49:59 PM
#6095   Vaxart Inc (VXRT) mick 08/14/21 04:30:35 PM
#6094   This is the VXRT board Tamtam 08/09/21 06:12:52 PM
#6093   Ipix is expecting phase 2 results in next kingofsting 08/05/21 08:59:12 AM
#6092   Meeting this Thursday!!$$$ ChillingPenguin 08/02/21 06:10:33 PM
#6091   + 0.79 $ (+10.99%)huge volume: 25,117,191 Tamtam 08/02/21 06:00:47 PM
#6090   Its about time!!! Hopefully they announce the initiation ChillingPenguin 08/02/21 09:25:19 AM
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