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Tenax Therapeutics, Inc. (TENX)

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Last Post: 11/9/2020 8:59:18 AM - Followers: 118 - Board type: Free - Posts Today: 0



Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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#8102   News; $TENX Tenax Therapeutics Gains North American Rights whytestocks 10/15/20 07:15:28 PM
#8101   I'm sure he got right on it. Glider549 09/28/20 10:30:54 AM
#8100   Heavy insider buying here, director buys 311,481 shares hardcore 08/25/20 04:20:09 PM
#8099   Looks like $TENX cup n handle continuation pattern...that's TechnoAnalyst 07/31/20 04:26:39 PM
#8098   Agreed. LetGoodTimesRoll 07/19/20 11:12:01 PM
#8097   Yes I believe it is!! Hate that management makingbiigdough 07/18/20 12:28:52 PM
#8096   Still holding 80k, I know the move is hardcore 07/18/20 12:09:32 PM
#8095   Yes to your? My D homeboy! MBD makingbiigdough 07/18/20 11:27:07 AM
#8094   TENX- I think we are seeing a more hardcore 07/17/20 11:29:32 AM
#8093   What’s this all about? BluSkies 07/14/20 10:14:07 PM
#8092   The company really shit all over this with BlindSquirrelFindsNuts 06/30/20 03:53:29 PM
#8091   Results on such a large indication seemed impressive. BioAddict 06/03/20 12:16:28 PM
#8090   Some shady crap. I glanced at some filings BlindSquirrelFindsNuts 06/03/20 10:52:38 AM
#8089   What are your thoughts on this blind squirrel? BioAddict 06/03/20 10:43:32 AM
#8088   Lower PPS than prior to the positive results. BlindSquirrelFindsNuts 06/03/20 10:25:36 AM
#8087   That was my thought. The P2 was BioAddict 06/02/20 05:23:02 PM
#8086   * * $TENX Video Chart 06-02-2020 * * ClayTrader 06/02/20 04:53:26 PM
#8085   News Pt3 06/02/20 04:25:17 PM
#8084   Cool - I'm still adding it! Walker 06/02/20 02:48:22 PM
#8083   TENX - Stupid Robinhood traders going in and hardcore 06/02/20 10:14:40 AM
#8082   Added here Liquid1974 06/02/20 09:43:41 AM
#8081   Huge pop coming!! No shares available! Float/OS ALREADY makingbiigdough 06/02/20 09:41:30 AM
#8080   What happens to it today? Was that all GKG 06/02/20 08:19:36 AM
#8079   Nice "gut" analysis! > 2.64 in PM. crudeoil24 06/02/20 07:43:47 AM
#8078   Yes my friend, 25k:-) MBD makingbiigdough 06/02/20 12:19:45 AM
#8077   Tomorrow the phase 2 top line data should Tommy321 06/01/20 05:08:49 PM
#8076   You get any? Just barely getting Walker 06/01/20 05:03:41 PM
#8075   Yes makingbiigdough 06/01/20 05:00:58 PM
#8074   You think their heart drug will get approved Logic1 05/29/20 06:45:59 PM
#8073   Whats the big story here bro? Surprise your still casenumber 05/28/20 11:23:29 PM
#8072   Thanks my friend!!! I will definitely dd this!!! MBD makingbiigdough 05/28/20 07:57:48 PM
#8071   LOL - just sent you a PM Walker 05/28/20 03:15:49 PM
#8070   Yes my friend, I can see PM! Please makingbiigdough 05/27/20 12:04:04 PM
#8069   Holding up strong! Have a very interesting Walker 05/27/20 10:03:57 AM
#8068   TENX 20+ Million shares traded day coming soon!! makingbiigdough 05/26/20 03:26:20 PM
#8067   Love makingbiigdough on a quiet board! MEANS that makingbiigdough 05/26/20 12:08:43 PM
#8066   The way this is trading Walker, my gut makingbiigdough 05/22/20 12:23:09 PM
#8065   YES these prices are a steal! I paid makingbiigdough 05/21/20 08:14:29 PM
#8064   Been watching for a while and pissed I Walker 05/21/20 07:26:56 AM
#8063   Lol...4hrs MEANS Long!! Lolol makingbiigdough 05/20/20 06:16:16 PM
#8062   Yep - back in the good ole days. Walker 05/20/20 05:17:58 PM
#8061   Yes my OG FRIEND!! I remember you from makingbiigdough 05/20/20 05:07:32 PM
#8060   Something is up - good Phase II results? Walker 05/20/20 02:03:49 PM
#8059   Grabbed a bunch yesterday and will be adding Walker 05/20/20 09:10:50 AM
#8058   Yes Walker, I truly believe it's TENX time. makingbiigdough 05/20/20 09:09:45 AM
#8057   Looking good! Walker 05/19/20 04:04:24 PM
#8056   Nice and slow. MBD makingbiigdough 05/19/20 03:46:14 PM
#8055   Just the beginning!!!! MBD makingbiigdough 05/15/20 04:22:08 PM
#8054   So manipulated!! I just Continue to buy and makingbiigdough 05/07/20 10:06:43 AM
#8053   Good stuff. $AKTX strong news this morning if Rogerthat1 05/01/20 07:56:38 AM
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