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Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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#7720   MM UBSS sat on bid ALL day @1.95 makingbiigdough 03/20/19 04:24:08 PM
#7719   God Bless you my friend!! MBD makingbiigdough 03/20/19 03:17:43 PM
#7718   In at $2 with a boatload. GL wolfden2018 03/20/19 01:01:05 PM
#7717   First of all Amen to your favorite quote!!! makingbiigdough 03/20/19 12:02:50 PM
#7716   why would it go to $5 this week. wolfden2018 03/20/19 09:50:49 AM
#7715   Been loading here, moves on air. $TENX timmage 03/19/19 01:25:09 PM
#7714   Once we get past $2.32 should start seeing makingbiigdough 03/19/19 11:58:29 AM
#7713   Expecting a nice bump in pps today! Blessings makingbiigdough 03/19/19 07:06:19 AM
#7712   Very nice find! casenumber 03/18/19 05:59:11 PM
#7711   Nothing more needs to be said!! Q4 Earnings makingbiigdough 03/18/19 05:24:29 PM
#7710   The way TENX is trading I'm Gonna go makingbiigdough 03/18/19 03:41:19 PM
#7709   When news hits here.... going to be so makingbiigdough 03/18/19 02:57:27 PM
#7708   Moving back up soon!! Something definitely going on makingbiigdough 03/18/19 01:48:51 PM
#7707   NO-BRAINER HERE!!!!! $5-7++++ Coming this week!!!!! MBD makingbiigdough 03/18/19 01:21:58 PM
#7706   Major squeeze coming. Tons of shares shorted last casenumber 03/18/19 12:55:49 PM
#7705   This will blast off. Shorts will cover soon BB-ADVISOR 03/18/19 12:44:12 PM
#7704   Flippers burn BB-ADVISOR 03/18/19 12:37:05 PM
#7703   Beast mode activated Ask assault! casenumber 03/18/19 12:32:01 PM
#7702   Going green soon!!!Flippers/Daytraders who bought in on the makingbiigdough 03/18/19 12:23:44 PM
#7701   Added more on this dip!MBD makingbiigdough 03/18/19 10:44:53 AM
#7700   GM Let's roll! In $TENX ~$2, been averaging RobbinGood 03/18/19 08:44:23 AM
#7699   Good morning all TENX Shareholders! I am expecting makingbiigdough 03/18/19 06:32:33 AM
#7698   9.25 Analyst target...could be more depending on the casenumber 03/17/19 10:26:08 PM
#7697   Hope so!! stock_observer_77 03/17/19 09:38:00 PM
#7696   Going to be an awesome week ahead for makingbiigdough 03/17/19 06:59:25 PM
#7695   Taking a broader look brokerage firms’ analysts on casenumber 03/16/19 12:32:45 AM
#7694   What are we expecting here? Something big? Jesusman 03/15/19 07:17:17 PM
#7693   Lol...I don't listen to word on the street! makingbiigdough 03/15/19 04:22:08 PM
#7692   Buyout? social media buzz?? do you have the link? Pennyes 03/15/19 04:18:53 PM
#7691   Major squeeze and a buy out word on casenumber 03/15/19 04:09:48 PM
#7690   Thanks bud ! Same to you. BB-ADVISOR 03/15/19 04:09:02 PM
#7689   Yes my friend!! Enjoy your weekend!! God Bless makingbiigdough 03/15/19 04:05:05 PM
#7688   Here we go!! BB-ADVISOR 03/15/19 03:56:31 PM
#7687   Could today be our money making day!!? Have makingbiigdough 03/15/19 04:10:36 AM
#7686   1 for 20 reverse split effective 2/26/2018, millions sosjtb 03/14/19 03:56:19 PM
#7684   Nowhere i see as rs history on TENX casenumber 03/14/19 01:09:39 PM
#7683   Who there....way more than 1.5 Million shares, that was sosjtb 03/14/19 11:30:58 AM
#7682   Looking good!! Any day now!! PATIENCE!!!! MBD makingbiigdough 03/14/19 11:03:33 AM
#7681   18m volume couple of days ago are all casenumber 03/13/19 09:25:53 PM
#7680   TENX!! I'm with you guys!! Shorts going to makingbiigdough 03/13/19 03:28:07 PM
#7679   Not sank as you wish??? That allready used Stockrocketer 03/13/19 03:10:52 PM
#7678   This sob needs to head to the clouds .move Milehighclub1972 03/13/19 10:15:33 AM
#7677   TENX....BPTH like in the making here! Major squeeze coming casenumber 03/09/19 12:28:12 AM
#7676   Squeeze em $TENX PENNYBUSTER 03/08/19 08:43:32 PM
#7675   * * $TENX Video Chart 03-08-2019 * * ClayTrader 03/08/19 04:57:17 PM
#7674   HOD 2.79 .Price target is $9.25 a share as casenumber 03/08/19 03:35:37 PM
#7673   Nailed bottoms on this and BPT~. If Werbe 03/08/19 01:32:17 PM
#7672   2.05 HOD casenumber 03/07/19 01:04:16 PM
#7671   Trying to make some moves back up this morning! Curt D 03/04/19 11:15:12 AM
#7670   The recent offering was at $1.93 retireat40 03/02/19 02:30:47 PM
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