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Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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News News Alert: Current Report Filing (8-k) 12/11/2018 04:07:59 PM
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#7632   How about a coiled spring bounce back today! crudeoil24 12/10/18 08:34:57 AM
#7631   1.54 TENX [SMART MONEY] 12/10/18 08:33:18 AM
#7630   Wow. What happened here today? That was one jmorexxnet 12/08/18 01:19:56 AM
#7629   * * $TENX Video Chart 12-07-18 * * ClayTrader 12/07/18 04:00:40 PM
#7628   Brokerages predict that Tenax Therapeutics Inc (NASDAQ:TENX) will casenumber 12/07/18 02:58:45 PM
#7627   “MORRISVILLE, N.C.--(BUSINESS WIRE)--Tenax Therapeutics, Inc. (Nasdaq: TENX) (“T casenumber 12/07/18 02:34:41 PM
#7626   Not really. Catch a good pps at 1.63 casenumber 12/07/18 02:27:29 PM
#7625   ouch! catching a falling knife NEVER a lollybella 12/07/18 02:21:13 PM
#7624   Yep... did not sell but 12k down oh my europtiger 12/07/18 01:57:20 PM
#7623   Back in @163 Lets go..... casenumber 12/07/18 01:39:57 PM
#7622   Halted? No trade for the last 5 Wth casenumber 12/07/18 01:13:07 PM
#7621   Bad dirty game they just played. 867moneytime 12/07/18 01:07:46 PM
#7620   Sorry but your screwed. 867moneytime 12/07/18 01:06:04 PM
#7619   Got me 3,90‘s europtiger 12/07/18 12:53:29 PM
#7618   That 200K buy took it above 5.00 > crudeoil24 12/07/18 11:07:49 AM
#7617   wash out 5.12-4.37 [SMART MONEY] 12/07/18 11:03:31 AM
#7616   Up 185% @ 4.80 > Well, you have crudeoil24 12/07/18 10:22:20 AM
#7615   Hoping for good things soon RisingMT 09/20/18 05:05:47 PM
#7614   OXYCYTE WORKS! 2006 article in POPULAR SCIENCE. RajunCajun 07/17/18 04:03:20 PM
#7613   Your investment! READ LAST POST! Hidden in plain RajunCajun 07/17/18 03:05:02 PM
#7612   OXYCYTE strange name change .... Aurum’s ABL-101 stroke RajunCajun 07/17/18 02:46:40 PM
#7611   Out @ $6.45 for now. Met short term chmcnfunds 06/06/18 12:38:06 PM
#7610   Tenax Therapeutics Announces Study Design for Phase 2 chmcnfunds 06/01/18 09:04:22 AM
#7609   Back in @ $6.05. Chart a little less chmcnfunds 05/30/18 03:22:38 PM
#7608   Sold @ $6.25. Looking to get back in chmcnfunds 05/29/18 03:57:04 PM
#7607   Great trade for profit and good timing to chmcnfunds 05/21/18 04:25:14 PM
#7606   Out at 8.75.. gl all! :) Santo 03/12/18 01:38:38 PM
#7605   Nice move, a lot of strength, trying to Heycenda 03/06/18 02:33:28 PM
#7604   Bought this Friday at 7.75.. gl all Santo 03/05/18 09:54:45 AM
#7603   I agree. At close, I sold the few north40000 03/01/18 04:32:31 PM
#7602   Where was everyone...Bought At 5.22 !!! zino 03/01/18 04:27:31 PM
#7601   HALT again! PyschoNoobStock 03/01/18 12:43:31 PM
#7600   BOOM.. Broke new high of the day. PyschoNoobStock 03/01/18 12:41:03 PM
#7599   Today's results illustrate why prudence dictates that I davidsson10 03/01/18 12:34:03 PM
#7598   Outstanding Shares 1,411,827 02/26/2018 PyschoNoobStock 03/01/18 12:25:18 PM
#7597   08:23 AM EST, 02/23/2018 (MT Newswires) -- Tenax PyschoNoobStock 03/01/18 12:14:43 PM
#7596   Tenax Says Levosimendan Improves Right Heart Function in PyschoNoobStock 03/01/18 12:12:19 PM
#7595   suspended? jpowellvlc 03/01/18 11:40:48 AM
#7594   lol congrats! Tdash 03/01/18 11:27:38 AM
#7593   Zino only i-hubber here...lol zino 03/01/18 11:25:22 AM
#7592   1.4 Million Shares Outstanding...LoL zino 03/01/18 10:48:52 AM
#7591   In at 5.22 Explosion on news today...Cuz SS zino 03/01/18 10:26:17 AM
#7590   approximately 1.4 million post-reverse split shares zino 03/01/18 10:25:51 AM
#7589   1:20 R/S Monday. davidsson10 02/23/18 08:10:11 AM
#7588   Why reverse split? Are Tenax’s shareholders misled? Rumpelstilz 02/12/18 05:06:05 AM
#7587   Scottish State institutions being informed on Tenax’s SEC problem Rumpelstilz 02/05/18 09:54:56 AM
#7586   Tenax-Aurum: Will Jebsen hamper Scottish IPO? Rumpelstilz 01/31/18 11:54:59 AM
#7585   Scottish State money involved in Tenax-Aurum deal Rumpelstilz 01/29/18 10:19:59 AM
#7584   Tenax, SEC, Scottish Parliament: Could conference call bring clarity? Rumpelstilz 01/26/18 03:20:25 PM
#7583   Oxycyte: Backed by Scottish Parliament, but missing in Rumpelstilz 01/26/18 09:02:10 AM
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