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Medical - Drugs
Tenax Therapeutics, Inc. (TENX)
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11/9/2020 8:59:18 AM
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Tenax Therapeutics Corporate update - November 2016
Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
Surgery will employ CPB pump
Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study
Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
Weight ≥ 170 kg.
Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
Hemoglobin < 80 g/L.
Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
A history of Torsades de Pointes.
Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
Liver dysfunction Child Pugh Class B or C
Patients having severely compromised immune function
Pregnant, suspected to be pregnant, or breast-feeding.
Received an experimental drug or used an experimental medical device in previous 30 days.
Known allergic reaction or sensitivity to Levosimendan or excipients.
Received commercial Levosimendan within 30 days before the planned start of study drug.
Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.
Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion
TENX Detailed Quote
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My Stocks (69)
Tenax Therapeutics Gains North American Rights
10/15/20 07:15:28 PM
I'm sure he got right on it.
09/28/20 10:30:54 AM
Heavy insider buying here, director buys 311,481 shares
08/25/20 04:20:09 PM
Looks like $TENX cup n handle continuation pattern...that's
07/31/20 04:26:39 PM
07/19/20 11:12:01 PM
Yes I believe it is!! Hate that management
07/18/20 12:28:52 PM
Still holding 80k, I know the move is
07/18/20 12:09:32 PM
Yes to your? My D homeboy! MBD
07/18/20 11:27:07 AM
TENX- I think we are seeing a more
07/17/20 11:29:32 AM
What’s this all about?
07/14/20 10:14:07 PM
The company really shit all over this with
06/30/20 03:53:29 PM
Results on such a large indication seemed impressive.
06/03/20 12:16:28 PM
Some shady crap. I glanced at some filings
06/03/20 10:52:38 AM
What are your thoughts on this blind squirrel?
06/03/20 10:43:32 AM
Lower PPS than prior to the positive results.
06/03/20 10:25:36 AM
That was my thought. The P2 was
06/02/20 05:23:02 PM
* * $TENX Video Chart 06-02-2020 * *
06/02/20 04:53:26 PM
06/02/20 04:25:17 PM
Cool - I'm still adding it!
06/02/20 02:48:22 PM
TENX - Stupid Robinhood traders going in and
06/02/20 10:14:40 AM
06/02/20 09:43:41 AM
Huge pop coming!! No shares available! Float/OS ALREADY
06/02/20 09:41:30 AM
What happens to it today? Was that all
06/02/20 08:19:36 AM
Nice "gut" analysis! > 2.64 in PM.
06/02/20 07:43:47 AM
Yes my friend, 25k:-) MBD
06/02/20 12:19:45 AM
Tomorrow the phase 2 top line data should
06/01/20 05:08:49 PM
You get any? Just barely getting
06/01/20 05:03:41 PM
06/01/20 05:00:58 PM
You think their heart drug will get approved
05/29/20 06:45:59 PM
Whats the big story here bro? Surprise your still
05/28/20 11:23:29 PM
Thanks my friend!!! I will definitely dd this!!! MBD
05/28/20 07:57:48 PM
LOL - just sent you a PM
05/28/20 03:15:49 PM
Yes my friend, I can see PM! Please
05/27/20 12:04:04 PM
Holding up strong! Have a very interesting
05/27/20 10:03:57 AM
TENX 20+ Million shares traded day coming soon!!
05/26/20 03:26:20 PM
Love makingbiigdough on a quiet board! MEANS that
05/26/20 12:08:43 PM
The way this is trading Walker, my gut
05/22/20 12:23:09 PM
YES these prices are a steal! I paid
05/21/20 08:14:29 PM
Been watching for a while and pissed I
05/21/20 07:26:56 AM
Lol...4hrs MEANS Long!! Lolol
05/20/20 06:16:16 PM
Yep - back in the good ole days.
05/20/20 05:17:58 PM
Yes my OG FRIEND!! I remember you from
05/20/20 05:07:32 PM
Something is up - good Phase II results?
05/20/20 02:03:49 PM
Grabbed a bunch yesterday and will be adding
05/20/20 09:10:50 AM
Yes Walker, I truly believe it's TENX time.
05/20/20 09:09:45 AM
05/19/20 04:04:24 PM
Nice and slow. MBD
05/19/20 03:46:14 PM
Just the beginning!!!! MBD
05/15/20 04:22:08 PM
So manipulated!! I just Continue to buy and
05/07/20 10:06:43 AM
Good stuff. $AKTX strong news this morning if
05/01/20 07:56:38 AM
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My Stocks (69)
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