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Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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#8046   TENX, I have that feeling that something is makingbiigdough 04/01/20 11:40:59 AM
#8045   TENX!! The part I really like!!! TENX has makingbiigdough 03/31/20 10:26:21 AM
#8044   Rogerthat!! Lol...Going to be a VERY FUN RIDE makingbiigdough 03/31/20 09:37:08 AM
#8043   $TENX To date, we own or in-license the Rogerthat1 03/31/20 08:01:10 AM
#8042   TENX like I've been saying! Sooner than later, makingbiigdough 03/30/20 11:32:40 PM
#8041   $TENX "Based on our working capital at December Rogerthat1 03/30/20 09:52:24 PM
#8040   $TENX "We believe that the combination of the Rogerthat1 03/30/20 09:49:54 PM
#8039   Print Release makingbiigdough 03/27/20 10:25:11 PM
#8038   Co has basically told us that data will Rogerthat1 03/27/20 07:22:19 PM
#8037   All we have to do is be a makingbiigdough 03/27/20 04:38:31 PM
#8036   Bought more today. Boat is so loaded there Rogerthat1 03/27/20 11:52:20 AM
#8035   TENX is so under the radar!! I have makingbiigdough 03/27/20 01:17:41 AM
#8034   Thank you mbd. Appreciate that google translate. If Rogerthat1 03/27/20 12:32:18 AM
#8033   HERE YOU GO MY FRIEND! THANK GOD I makingbiigdough 03/26/20 08:07:30 PM
#8032   Last thing I will say is GET AS makingbiigdough 03/26/20 07:56:19 PM
#8031   Look at my post 8019!! The link is makingbiigdough 03/26/20 07:53:29 PM
#8030   I made A KILLING ON BPTH when it makingbiigdough 03/26/20 07:49:17 PM
#8029   Yeah broker doesn’t let me put gtc orders Rogerthat1 03/26/20 07:49:08 PM
#8028   Lol...I have it at that price because I makingbiigdough 03/26/20 07:45:48 PM
#8027   What article is this? I don’t read Chinese. Rogerthat1 03/26/20 07:43:00 PM
#8026   What do you mean by price $72.50? Jeez Rogerthat1 03/26/20 07:34:55 PM
#8025   Hello my friend! This has been one helluva makingbiigdough 03/26/20 07:32:55 PM
#8024   Guess what I’ve been loading last two days Rogerthat1 03/26/20 04:20:14 PM
#8023   TENX any day now! MBD makingbiigdough 03/26/20 12:37:37 PM
#8022   TENX... Dilution should be done at any moment makingbiigdough 03/25/20 11:25:56 AM
#8021   TENX! When the next News release drops, the makingbiigdough 03/23/20 10:34:16 AM
#8020   When TENX finally pops! OMG it's going to makingbiigdough 03/20/20 02:59:39 PM
#8019   TENX is helping CV PATIENTS ALL OVER THE makingbiigdough 03/18/20 05:41:01 PM
#8018   Totally agree Couldn't have had an offering on makingbiigdough 03/12/20 12:47:39 PM
#8017   Geez what kind of F'n idiots do an BlindSquirrelFindsNuts 03/12/20 12:08:37 PM
#8016   Looks like I’ll be buying more today hardcore 03/12/20 11:26:17 AM
#8015   Someone just picked 10k shares at a quarter! BlindSquirrelFindsNuts 03/12/20 10:01:50 AM
#8014   TENX not going to be a hidden gem makingbiigdough 03/10/20 07:04:43 PM
#8013   TENX Smart man Hardcore!! Add 125k+ to that makingbiigdough 03/09/20 01:36:42 PM
#8012   Just thinking out of the box! Enrollment for makingbiigdough 03/09/20 11:37:27 AM
#8011   TENX call me STUPID, but I'm buying more makingbiigdough 03/04/20 08:58:52 PM
#8010   Coronavirus NOT going away anytime soon!! Mark my makingbiigdough 03/04/20 08:41:24 PM
#8009   JUST remaining Patient keeping the FAITH here and makingbiigdough 03/02/20 03:11:56 PM
#8008   $TENX is the next CODX+!! Monster move coming makingbiigdough 03/02/20 05:02:14 AM
#8007   Something is up here. Unusual volume and Dr. Steve Brule 03/01/20 04:42:09 PM
#8006   Major reversal coming soon!!! We will see how makingbiigdough 02/27/20 10:25:45 AM
#8005   Need 10x from here to break even.. worthless RisingMT 02/27/20 08:06:44 AM
#8004   I have ALWAYS kept it real and honest makingbiigdough 02/23/20 07:53:06 PM
#8003   TENX, Any day now, about to make some makingbiigdough 02/20/20 11:24:07 AM
#8002   PEOPLE sitting on the sidelines waiting for an makingbiigdough 02/14/20 02:28:37 PM
#8001   If institutions like BLACK ROCK Continue to buy, makingbiigdough 02/07/20 09:44:42 AM
#8000   Yes my Detwoi pmp!! Call me STUPID but makingbiigdough 02/06/20 05:35:25 PM
#7999   TENX 1.19 - Getting cheaper, you loading more? hardcore 02/06/20 03:50:26 PM
#7998   Great job my friend! Now just sit back makingbiigdough 01/31/20 09:57:45 AM
#7997   Huge bull pennant got mine TradeNaked 01/31/20 09:31:43 AM
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