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Medical - Drugs
Tenax Therapeutics, Inc. (TENX)
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4/1/2020 11:40:59 AM
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Tenax Therapeutics Corporate update - November 2016
Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
Surgery will employ CPB pump
Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study
Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
Weight ≥ 170 kg.
Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
Hemoglobin < 80 g/L.
Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
A history of Torsades de Pointes.
Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
Liver dysfunction Child Pugh Class B or C
Patients having severely compromised immune function
Pregnant, suspected to be pregnant, or breast-feeding.
Received an experimental drug or used an experimental medical device in previous 30 days.
Known allergic reaction or sensitivity to Levosimendan or excipients.
Received commercial Levosimendan within 30 days before the planned start of study drug.
Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.
Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion
TENX Detailed Quote
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My Stocks (67)
TENX, I have that feeling that something is
04/01/20 11:40:59 AM
TENX!! The part I really like!!! TENX has
03/31/20 10:26:21 AM
Rogerthat!! Lol...Going to be a VERY FUN RIDE
03/31/20 09:37:08 AM
$TENX To date, we own or in-license the
03/31/20 08:01:10 AM
TENX like I've been saying! Sooner than later,
03/30/20 11:32:40 PM
$TENX "Based on our working capital at December
03/30/20 09:52:24 PM
$TENX "We believe that the combination of the
03/30/20 09:49:54 PM
03/27/20 10:25:11 PM
Co has basically told us that data will
03/27/20 07:22:19 PM
All we have to do is be a
03/27/20 04:38:31 PM
Bought more today. Boat is so loaded there
03/27/20 11:52:20 AM
TENX is so under the radar!! I have
03/27/20 01:17:41 AM
Thank you mbd. Appreciate that google translate. If
03/27/20 12:32:18 AM
HERE YOU GO MY FRIEND! THANK GOD I
03/26/20 08:07:30 PM
Last thing I will say is GET AS
03/26/20 07:56:19 PM
Look at my post 8019!! The link is
03/26/20 07:53:29 PM
I made A KILLING ON BPTH when it
03/26/20 07:49:17 PM
Yeah broker doesn’t let me put gtc orders
03/26/20 07:49:08 PM
Lol...I have it at that price because I
03/26/20 07:45:48 PM
What article is this? I don’t read Chinese.
03/26/20 07:43:00 PM
What do you mean by price $72.50? Jeez
03/26/20 07:34:55 PM
Hello my friend! This has been one helluva
03/26/20 07:32:55 PM
Guess what I’ve been loading last two days
03/26/20 04:20:14 PM
TENX any day now! MBD
03/26/20 12:37:37 PM
TENX... Dilution should be done at any moment
03/25/20 11:25:56 AM
TENX! When the next News release drops, the
03/23/20 10:34:16 AM
When TENX finally pops! OMG it's going to
03/20/20 02:59:39 PM
TENX is helping CV PATIENTS ALL OVER THE
03/18/20 05:41:01 PM
Totally agree Couldn't have had an offering on
03/12/20 12:47:39 PM
Geez what kind of F'n idiots do an
03/12/20 12:08:37 PM
Looks like I’ll be buying more today
03/12/20 11:26:17 AM
Someone just picked 10k shares at a quarter!
03/12/20 10:01:50 AM
TENX not going to be a hidden gem
03/10/20 07:04:43 PM
TENX Smart man Hardcore!! Add 125k+ to that
03/09/20 01:36:42 PM
Just thinking out of the box! Enrollment for
03/09/20 11:37:27 AM
TENX call me STUPID, but I'm buying more
03/04/20 08:58:52 PM
Coronavirus NOT going away anytime soon!! Mark my
03/04/20 08:41:24 PM
JUST remaining Patient keeping the FAITH here and
03/02/20 03:11:56 PM
$TENX is the next CODX+!! Monster move coming
03/02/20 05:02:14 AM
Something is up here. Unusual volume and
Dr. Steve Brule
03/01/20 04:42:09 PM
Major reversal coming soon!!! We will see how
02/27/20 10:25:45 AM
Need 10x from here to break even.. worthless
02/27/20 08:06:44 AM
I have ALWAYS kept it real and honest
02/23/20 07:53:06 PM
TENX, Any day now, about to make some
02/20/20 11:24:07 AM
PEOPLE sitting on the sidelines waiting for an
02/14/20 02:28:37 PM
If institutions like BLACK ROCK Continue to buy,
02/07/20 09:44:42 AM
Yes my Detwoi pmp!! Call me STUPID but
02/06/20 05:35:25 PM
TENX 1.19 - Getting cheaper, you loading more?
02/06/20 03:50:26 PM
Great job my friend! Now just sit back
01/31/20 09:57:45 AM
Huge bull pennant got mine
01/31/20 09:31:43 AM
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