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Last Post: 5/21/2019 1:00:08 PM - Followers: 122 - Board type: Free - Posts Today: 0



Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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#7801   Wow, that's a bold claim that this will Luckynumber7 05/21/19 01:00:08 PM
#7800   TENX!!! Patience, Patience, Patience. Our day will makingbiigdough 05/21/19 08:02:43 AM
#7799   TENX acting like my previous 7+ figure monster! makingbiigdough 05/16/19 03:07:17 PM
#7798   TENX!! 10Q out ah!! Get ready, ever so makingbiigdough 05/15/19 07:29:48 PM
#7797   TENX!!! Patience is the key my brother!!! BLESSINGS makingbiigdough 05/14/19 04:40:07 PM
#7796   Key level here. I don’t doubt this alphaInvestor2 05/14/19 01:27:34 PM
#7795   Sure hope we are spot-on! Added a little makingbiigdough 05/13/19 07:07:06 PM
#7794   You are spot on. obvious accumulation in alphaInvestor2 05/13/19 01:04:20 PM
#7793   TENX... This has been SO held down under makingbiigdough 05/13/19 09:53:16 AM
#7792   TENX!!! God is really testing my PATIENCE once makingbiigdough 05/07/19 02:40:02 PM
#7791   it's coming..... vhgier 05/06/19 11:16:58 AM
#7790   TENX...Time to get moving northward now!!! I have makingbiigdough 05/03/19 02:08:47 PM
#7789   TENX!!!! Will follow ABIO real soon, with way makingbiigdough 05/01/19 08:41:41 PM
#7788   TENX...One day soon!! I shall not be moved! makingbiigdough 04/22/19 11:49:54 AM
#7787   TENX!!! Buying up these low $1.70's today maybe makingbiigdough 04/12/19 09:40:29 AM
#7786   TENX.. link was down for a moment is makingbiigdough 04/09/19 05:01:35 PM
#7785   TENX.... That link seemed not to be working makingbiigdough 04/09/19 04:29:19 PM
#7784   TENX!!! They did one before and are now makingbiigdough 04/09/19 04:24:16 PM
#7783   Any links?.....Would be real nice, if true. stockdawg44 04/09/19 04:02:17 PM
#7782   TENX about to get BIG-TIME exposure! Hearing a makingbiigdough 04/09/19 03:58:31 PM
#7781   TENX....News could drop at anytime! Adding on all makingbiigdough 04/09/19 08:07:54 AM
#7780   Well it’s one of the risks noted in RisingMT 04/08/19 11:52:06 AM
#7778   Licenses generate revenue. casenumber 04/07/19 01:18:50 PM
#7777   We are all pretty much relying on the RisingMT 04/07/19 01:06:04 PM
#7776   TENX!!! $2 AH CLOSE:-) MBD makingbiigdough 04/05/19 09:47:30 PM
#7775   TENX YESSS GOT MY CHEAPIES!!! Whenever we get makingbiigdough 04/05/19 02:22:04 PM
#7774   TENX...I will take the $1.83/84's out soon! Adding makingbiigdough 04/05/19 12:27:59 PM
#7773   Lol ..yes they do my brother. Just hang makingbiigdough 04/04/19 01:40:06 AM
#7772   the problem is they shake soo hard that Opti Mist 04/03/19 08:10:39 PM
#7771   TENX.... Don't forget what you own!! LOT'S of makingbiigdough 04/03/19 05:29:32 PM
#7770   TENX.. wasn't expecting much in the 10K. Cash makingbiigdough 04/01/19 05:18:51 PM
#7769   ER today PM no shorts 04/01/19 11:16:41 AM
#7768   Agreed! I'm with you, Faith & Trust is makingbiigdough 03/31/19 04:51:09 PM
#7767   Anyone who is an experienced investor knows there Opti Mist 03/31/19 03:35:49 PM
#7766   TENX Levosimendan is what we refer to as makingbiigdough 03/31/19 09:56:08 AM
#7765   RSI ready to run into the Power Zone...Looking Golden_Cross 03/28/19 06:30:11 PM
#7764   Yes...Lolol ..Go TENX!MBD makingbiigdough 03/28/19 06:16:07 PM
#7763   TENX.. Fair analysis clay my Michigander. Although You makingbiigdough 03/28/19 06:01:12 PM
#7762   * * $TENX Video Chart 03-28-2019 * * ClayTrader 03/28/19 05:51:01 PM
#7761   Buddy on the board saw a 911 trade.. Imarket13 03/28/19 05:50:08 PM
#7760   Was looking for something.... can’t find anything... can jonnyvs 03/28/19 05:46:48 PM
#7759   $2.00 just hit [SMART MONEY] 03/28/19 05:43:00 PM
#7758   Some one just bought 26k worth Imarket13 03/28/19 03:19:52 PM
#7757   Last week you said 5 to 7 bucks Imarket13 03/28/19 02:09:09 PM
#7755   I thought it was gonna breakout when it Imarket13 03/28/19 02:05:16 PM
#7754   I have been wondering the same thing or KER12 03/28/19 02:01:52 PM
#7753   Seems like dilution happening.. it's a shame cuz Imarket13 03/28/19 02:00:15 PM
#7752   Who knows I have seen many times 911 KER12 03/28/19 01:57:18 PM
#7751   Wouldnt there be massive buying then ? 14 Imarket13 03/28/19 01:54:04 PM
#7750   Lol....Are you that naive!!?? They signal all the makingbiigdough 03/28/19 01:51:35 PM
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