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Tenax Therapeutics, Inc. (TENX)

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Last Post: 10/16/2019 1:03:02 PM - Followers: 123 - Board type: Free - Posts Today: 0

Tenax Therapeutics Corporate update - November 2016

Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


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#7967   Nothing but a waiting game going on over makingbiigdough 10/07/19 01:02:06 PM
#7966   ANYDAY now and this is gonna explode!!! Continually makingbiigdough 10/03/19 01:22:20 PM
#7965   "TENX IS THE REAL DEAL, INVESTORS SHOULD NOT makingbiigdough 09/22/19 08:54:43 AM
#7962   Lmao Hallucination.... casenumber 09/20/19 04:03:20 PM
#7961   I care, that's who cares!!! If I was makingbiigdough 09/20/19 04:01:32 PM
#7960   Nah ....im serious... casenumber 09/20/19 03:58:04 PM
#7959   I know you are probably just joking! But, makingbiigdough 09/20/19 03:57:01 PM
#7957   We will see who gets the last laugh, makingbiigdough 09/20/19 03:34:45 PM
#7956   Your little bird is a lying POS Lmao..... casenumber 09/20/19 02:41:38 PM
#7955   TENX!!! So close. MBD makingbiigdough 09/20/19 10:53:10 AM
#7954   TENX!! Come on Baby BRING us some News!! makingbiigdough 09/19/19 08:58:27 AM
#7953   Wow!! Looks like somebody got STOPPED OUT at makingbiigdough 09/18/19 02:25:43 PM
#7952   Added to my already overloaded boat! Let's see makingbiigdough 09/17/19 11:20:46 PM
#7951   TENX!! Blue light special sell going on! Thanks makingbiigdough 09/17/19 01:50:58 PM
#7950   TENX!! Yes it is my friend:-) I'm in makingbiigdough 09/17/19 08:06:53 AM
#7949   Its still climing with a low volume. You Biirdmaan 09/17/19 12:16:42 AM
#7948   Will be adding more tomorrow, and all this makingbiigdough 09/16/19 05:15:12 PM
#7947   Nobody's dumping! FAKE NEWS!! LMAO!!!! MBD makingbiigdough 09/16/19 04:17:13 PM
#7946   TENX someone looking to Dump a good amount swanlinbar 09/16/19 02:52:55 PM
#7945   Been watching for a while and jumped in Walker 09/14/19 08:28:38 PM
#7944   hey walker...nice of you to join us...this has vintagesake 09/14/19 02:12:52 AM
#7943   Added again - looking like strong bottom at 1.38-1.40 Walker 09/13/19 01:36:23 PM
#7942   TENX!! Just added a bunch more @$1.39!! I makingbiigdough 09/13/19 11:32:05 AM
#7941   Smart imo Congrats! Better avg then me.-:) MBD makingbiigdough 09/13/19 11:04:43 AM
#7940   Fine - added more just now. Walker 09/13/19 11:01:10 AM
#7939   Wink, wink! MBD makingbiigdough 09/13/19 10:48:38 AM
#7938   Grabbed some this am. Walker 09/13/19 10:34:39 AM
#7936   Last time, DEAD ON!!? Could be a lot makingbiigdough 09/13/19 01:19:15 AM
#7935   TENX!! Lil Birdy told me to anticipate a makingbiigdough 09/12/19 09:32:38 PM
#7934   TENX, Great things on the horizon! Very excited makingbiigdough 09/10/19 07:36:10 AM
#7933   This board has no activity or eyes on Dr. Steve Brule 09/09/19 06:32:37 AM
#7932   TENX, Looking forward to the coming days, weeks makingbiigdough 09/09/19 12:11:43 AM
#7931   TENX, All the MM's on the ask trying makingbiigdough 09/06/19 02:15:57 PM
#7930   1.32 now casenumber 09/04/19 12:49:51 PM
#7929   I am just sitting, kicking back enjoying the makingbiigdough 09/04/19 12:04:15 PM
#7928   1.30’s EOD 3’s or closer EOW Run wild next week casenumber 09/04/19 11:57:13 AM
#7927   TENX!!!! So so close to BLAST OFF LONGS!!!!! MBD makingbiigdough 09/04/19 09:37:47 AM
#7926   TENX, Everyday that passes by is another day makingbiigdough 09/03/19 03:07:43 PM
#7925   I must have missed it...when is this meeting vintagesake 08/30/19 03:19:41 PM
#7924   TENX!!! My AKTX running again on FDA NEWS!! makingbiigdough 08/30/19 09:35:39 AM
#7923   TENX.. H.C. Wainwright & Co. Is Once Again Ranked makingbiigdough 08/30/19 06:59:17 AM
#7922   TENX, More information on H.C.. makingbiigdough 08/30/19 06:30:34 AM
#7921   TENX!! Just in case anyone wanted to know makingbiigdough 08/30/19 06:25:20 AM
#7920   I see MM still in the heads of makingbiigdough 08/29/19 12:04:38 PM
#7919   3 and UP coming....Last time they talked to casenumber 08/29/19 11:56:23 AM
#7918   TENX IMO $2.20-2.50+ by Our 1 on 1 makingbiigdough 08/29/19 10:31:05 AM
#7917   TENX, Wink,wink! People have been crying about wanting makingbiigdough 08/29/19 09:17:26 AM
#7916   News out :) maybe you are right about Biirdmaan 08/29/19 08:48:05 AM
#7915   TENX, I predicted this! Zack's is definitely one makingbiigdough 08/29/19 06:14:11 AM
#7914   https://scr.zacks.com/News/Press-Releases/Press-Release-Details/2019/TENX-Focuse Biirdmaan 08/29/19 03:02:31 AM