Sernova Corp fka SVA

[Edgenation]

I’m really just waiting until patient #3 is considered fully insulin independent. 3’s a charm right (: . Been averaging down until it turns around.

[Flexroy]

What do you think the next possible catalyst is here?

[Edgenation]

Amazing news today with 100% Positive trials! This is going well above the current $2.12

[Edgenation]

Cheers!

[Flexroy]

Very promising stuff here. Cheers!

[Edgenation]

On Twitter today they announced that they’ll have an update on phase 1 & 2 !
Will be promising news if they are announcing ahead of time. Current price - $1.32

[Flexroy]

came for the insulin. stayed for the islets.

[Edgenation]

Amazing News!!!!

Sernova's Principal Investigator Presents Positive New Data from Ongoing Type 1 Diabetes (T1D) Clinical Trial at ATC 2021 Virtual Connect Conference

(TheNewswire)




Multiple patients with sustained clinical benefit, including positive fasting serum C-peptide (a biomarker of insulin produced by Sernova’s Cell Pouch islets) detected in their bloodstream


LONDON, ONTARIO – TheNewswire - June 7, 2021 – Sernova Corp. (TSXV:SVA) (OTC:SEOVF) (FSE/XETRA:PSH), a leading clinical-stage regenerative medicine therapeutics company today announced that its principal investigator, Dr. Piotr Witkowski, presented new preliminary data from Sernova’s ongoing U.S. Phase I/II T1D clinical trial at the University of Chicago. Dr. Witkowski’s presented the data at the American Transplant Congress (ATC) 2021 Virtual Connect conference on Saturday June 5, 2021.

The overall objective of the clinical trial is to assess the safety, tolerability, and efficacy of the Cell Pouch with insulin-producing islets. In addition to other criteria, prior to entry into the study, the patients must demonstrate long-standing T1D with severe hypoglycemic unawareness episodes and no glucose-stimulated C-peptide circulating in their bloodstream.

Dr. Witkowski’s presentation entitled “Islet Allotransplantation Into The Pre-Vascularized Sernova Cell PouchTM Device - Preliminary Results Of The Phase I/II Prospective, Open-Label, Single-Arm Study At University of Chicago” highlighted the following key points:

- 6 patients are implanted with Cell Pouches and continue to meet the study’s primary safety endpoint;

- 5 patients have now been transplanted with at least one dose of therapeutic cells (insulin producing islets) and are in different stages of the clinical trial; and

- most significantly, positive fasting serum C-peptide has been detected in the bloodstream of 4 patients so far. C-peptide is a biomarker for insulin produced by the islets in the Cell Pouch.

In addition to the continued confirmation of ongoing safety and tolerability in all currently enrolled patients, Dr. Witkowski provided further updates on the longest treated study patients. These patients continue to show defined clinical benefit associated with ongoing efficacy indicators including:

- reduction/elimination in the need for daily injectable insulin

- continued improvement, i.e. reduction/elimination, in Severe Hypoglycemic Events (SHE);

- persistent detection of fasting and stimulated C-peptide in patients’ bloodstream;

- reduction in HbA1c; and

- continued improvement of glucose control determined through patient blinded Continuous Glucose Monitoring (CGM) and measured by reduction of Time Above Range (TAR) and increase of Time in Range (TIR).

As previously reported, the most advanced patient in the study, who had achieved a ‘functional cure’ (requiring no injectable insulin) and had been insulin independent for 9 months, has now been insulin independent for 14 months with optimal glucose control.

“I believe Sernova is the first company in the world to demonstrate a subcutaneous vascularized device with therapeutic cells able to produce insulin in the bloodstream across multiple patients with the most severe diabetes. This is a remarkable feat. As the study progresses and our patient dataset continues to build, I am more confident than ever of the potential of Sernova’s regenerative medicine therapeutic platform,” said Dr. Philip Toleikis, President and CEO of Sernova. “Our vision of improving the lives of people suffering from diabetes with a ‘functional cure’ is another step closer to becoming a reality.”

[Edgenation]

Just got in Today @ $1.61
Holding for 1 year minimum

[Cannada]

No trolls here?! I love this place. What a breathe of fresh air compared to the other forums.

[StruckGold]

Sernova Receives US FDA IND Allowance to Initiate a US Clinical Trial of its Cell Pouch for the Treatment of Type 1 Diabetes
Source: Sernova Corp December 11, 2017, 6:00 a.m. EDT

LONDON, ONTARIO – (Globe Newswire – Monday December 11, 2017) – Sernova Corp. (TSX-V: SVA) (OTCQB: SEOVF) (FSE: PSH), a clinical stage company developing regenerative medicine technologies for the long-term treatment of diseases including diabetes and hemophilia, is pleased to announce it has received US Food and Drug Administration (FDA) notice of allowance for its IND for a new human clinical trial with the Cell Pouch System (TM) (CPS) in the United States. The Company will host a conference call for shareholders with Dr. Philip Toleikis, President and CEO on Monday, December 11th at 10:00am Eastern Standard Time to discuss the trial.

Sernova plans to initiate the new clinical trial under this US IND to investigate the Cell Pouch for treatment of type 1 diabetes (T1D) in individuals with hypoglycemia unawareness. The trial is a Phase I/II prospective single arm study of islets transplanted into the subcutaneously implanted Cell Pouch. The primary objective of the study is to demonstrate safety and tolerability of islet transplantation into the Cell Pouch and the secondary objective is to assess efficacy through a series of defined measures.

JDRF has previously committed to provide Sernova up to $2.45 million USD to support the clinical trial.

“Hypoglycemia unawareness is a serious consequence of type 1 diabetes,” said Derek Rapp, President & CEO, JDRF International. “We are excited to see progress in this and other potentially life-saving JDRF-funded research, which could help prevent people with hypoglycemia unawareness from experiencing dangerous lows, as we strive to achieve our vision of a world without T1D.”

“We are extremely enthusiastic about the promise of Sernova’s regenerative medicine platform to provide a new therapeutic option for diabetes patients with hypoglycemia unawareness. We believe Sernova’s multiple advancing cell based therapies have the potential to deliver significant improvement in the quality of life of patients suffering from diabetes and other debilitating diseases,” said Dr. Philip Toleikis, Sernova’s president & CEO.

About the Trial

The study is a Phase I/II single site, single arm, Company sponsored trial. Following approval by the Institutional Review Board, patients with hypoglycemia unawareness will be enrolled into the study under informed consent. Patients will then be implanted with the Cell Pouch including sentinel devices. Following vascularized tissue development, a dose of purified islets under strict release criteria will be transplanted into the Cell Pouch and patients followed for safety and efficacy measures for approximately six months. At this point a decision will be made whether to transplant a second islet dose with subsequent safety and efficacy follow up. Patients will then be further followed for one year.

“Sernova’s FDA clearance to commence human clinical trials in the United States is an exciting step forward in diabetes research, initially focused to reduce the risk of hypoglycemia unawareness, a complication in which a patient is unaware of a deep drop in blood sugar that can have life threatening consequences,” said Dave Prowten, President and CEO of JDRF Canada. “This is also an example of the international collaboration fostered by JDRF-funded projects to accelerate transformative research to benefit the T1D community,” added Mr. Prowten.

About Sernova’s Cell Pouch

The Cell Pouch is a novel, proprietary, scalable, implantable macroencapsulation device for the long-term survival and function of therapeutic cells (donor, stem cell derived cells and xenogeneic cells) which then release proteins and/or hormones as required to treat disease. The device is designed upon implantation to incorporate with tissue, forming highly vascularized tissue chambers for the transplantation and function of therapeutic cells. The device with therapeutic cells has been shown to provide long term safety and efficacy in small and large animal models of diabetes and has been proven to provide a biologically compatible environment for insulin producing cells in humans.

About Diabetes

T1D is a life-threatening disease in which the body's immune system mistakenly attacks and kills the pancreatic cells that produce insulin—a hormone that is essential for life because of its role to help the body use glucose. The existing standard of care for patients with TID is suboptimal. To date, there is no cure for T1D, and people living with the disease are dependent on exogenous insulin therapy to help keep their blood-sugar levels from spiking too high, which can lead to long-term complications such as kidney and heart diseases or an acute, potentially deadly health crisis. Present-day insulin therapy is, however, an imperfect treatment method that requires people with T1D to carefully monitor their blood sugar throughout the day and take multiple, calculated doses of insulin based on food intake, exercise, stress, illness and other factors. A miscalculation or unexpected variable leading to high or low blood sugar episodes are daily threats, and only a third of people with T1D achieve their long-term blood glucose targets, placing them at risk for T1D-related health complications.

Conference Call Details

To participate in this live conference call, please dial + 1-877-858-5743 prior to the scheduled conference call time. International callers should dial [phone]. The conference participant pass code is 355 040. Following the conference call a recording will be available at www.sernova.com

About Sernova Corp

Sernova Corp is developing disruptive regenerative medical technologies using a medical device and immune protected therapeutic cells to improve the treatment and quality of life of people with chronic metabolic diseases such as insulin-dependent diabetes, blood disorders including hemophilia, and other diseases treated through replacement of proteins or hormones missing or in short supply within the body. For more information, please visit www.sernova.com

About JDRF

JDRF is the leading global organization funding type 1 diabetes (T1D) research. Our mission is to accelerate life-changing breakthroughs to cure, prevent and treat T1D and its complications. To accomplish this, JDRF has invested nearly $2 billion in research funding since our inception. We are an organization built on a grassroots model of people connecting in their local communities, collaborating regionally for efficiency and broader fundraising impact, and uniting on a national stage to pool resources, passion, and energy. We collaborate with academic institutions, policymakers, and corporate and industry partners to develop and deliver a pipeline of innovative therapies to people living with T1D. Our staff and volunteers throughout the United States and our six international affiliates are dedicated to advocacy, community engagement and our vision of a world without T1D. For more information, please visit jdrf.org or follow us on Twitter: @JDRF

For further information contact:

Philip Toleikis, Ph.D., President and CEO Tel: [phone] [e-mail] www.sernova.com

Ray Matthews & Associates Tel: [phone]\ www.raymatthews.ca [e-mail]

Forward Looking Information This release may contain forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, “believes”, “intends”, “estimates”, “projects”, “potential” and similar expressions, or that events or conditions “will”, “would”, “may”, “could” or “should” occur. Although Sernova believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in forward looking statements. Forward-looking statements, are based on the beliefs, estimates and opinions of Sernova’s management on the date such statements were made, which include our belief about the conduct and outcome of clinical trials and that Sernova will be able to raise additional capital to fund its clinical programs including its planned US FDA clinical trial. Sernova expressly disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

[StruckGold]

Sernova closes $4.2-million private placement



2016-06-30 18:33 ET - News Release



Mr. Philip Toleikis reports

SERNOVA COMPLETES PRIVATE PLACEMENT OF $4,200,000

Sernova Corp. has completed a non-brokered private placement of $4.2-million, pursuant to which Sernova issued a total of 16.8 million units in two closings (June 27, 2016, and June 30, 2016).

Each unit issued in the private placement consists of one common share and one common share purchase warrant, and each warrant is exercisable into one share at a price of 35 cents per share for a 24-month exercise period, subject to abridgment of the exercise period (after the expiry of the four-month hold period) on 30 days notice to holders in the event that the 20-day volume-weighted price of the shares exceeds 50 cents.

The gross proceeds from the private placement will be used to finance a United States-based clinical trial ($2.5-million is allocated), and to finance Sernova's research and development programs, including corporate and academic collaborations ($1.2-million is allocated) using its platform technology to treat diabetes and other serious disease conditions, as well as for general corporate purposes (approximately $500,000).

The company compensated finders by way of cash fees of $130,462.50 and 521,850 non-transferable finder warrants, each such finder warrant having the same terms as the unit warrants. Finders were Richardson GMP, Echelon Wealth Partners, Gravitas Securities Inc., Aventine Management Group, Raymond James, Mackie Research Capital Corp., Canaccord Genuity, CMF AG and CRF Finance AG.

All of the securities issued in connection with the private placement are subject to a four-month hold period from the date of issuance in accordance with applicable provincial securities laws in Canada. The company confirms that there is no material fact or material change about the company that has not been generally disclosed.

We seek Safe Harbor.

[StruckGold]

Sernova Corp is a clinical stage company, developing highly disruptive platform technologies to treat chronic diseases through a regenerative medicine approach. Sernova’s primary focus is in developing technologies for the treatment of patients with insulin-dependent (TI) diabetes, and haemophilia A.

Sernova’s novel approach uses therapeutic cells placed into an implanted medical device to produce proteins or hormones which are in short supply or missing from the body due to the underlying disease state. The Cell Pouch System™, is an implantable, scalable medical device about the size of a business card which provides a natural “organ-like” environment for the long term survival and function of therapeutic cells such as insulin producing islets to treat diabetes. The Therapeutic Cells placed into the device may be natural (human) donor cells, or cells that can be a source to treat millions of patients including stem cell derived insulin responsive cells or xenogeneic cells. Sernova uses proprietary local immune protection technologies which protect therapeutic cells within the Cell Pouch™ from immune system attack reducing or eliminating the need for daily anti-rejection drugs. Sernova’s approach is designed to make future therapeutic cell replacement a simple outpatient procedure that can be performed in virtually any hospital setting. Using a medical device and therapeutic cell strategy to treat chronic diseases, Sernova is positioned for significant revenue upon commercialization of its “disruptive paradigm-shifting” platform technology.

Sernova’s team is focused on development of the Cell Pouch System™ for diabetes to treat both Type-1 and Type-2 patients who become insulin dependent – representing a treatable population of an estimated 50M patients worldwide currently taking insulin within Sernova’s patented countries. Sernova is also focused on development of the Cell Pouch System™ for the treatment of Hemophilia A through use of corrected patient’s cells placed in the Cell Pouch™ which is then expected to release Factor VIII at a constant rate.

TECHNOLOGY HIGHLIGHTS

The Standard of Care for patients with reduced or missing critical hormones or proteins such as insulin is often monitoring blood levels and injecting these proteins multiple times a day with a consequence of poor compliance and serious side effects resulting in over $150B/yr hospital costs for diabetes alone. Cell therapy is an alternative for patients with chronic diseases; however, there is no currently approved device to house and protect these cells in the body and no method to make the therapy a simple outpatient procedure. Instead, often cells are injected multiple times into blood vessels in an extremely expensive (>$100,000) and risky procedure, where many cells die through blood-derived inflammation and clotting, resulting in the need for repeat operations. Hence, the current standard of care for local cell therapy is limited by expensive procedures, poor cell survival and inappropriate delivery coupled with a lack of donors.
Sernova’s Cell Pouch System™ is a versatile, scalable implantable medical device made of materials approved for permanent use in the body, designed by biomedical engineers and biologists. Placed under the skin or in other locations, it develops organ-like characteristics (including vascularization) for survival and long term function of therapeutic cells. A natural environment where therapeutic cells are housed within a tissue matrix, rich in microvessels is expected to conserve cell number, and promote natural function - increasing cell survival, while significantly increasing the number of treatable patients beyond those with severe disease.
Sernova’s Therapeutic Cell technologies involve the use of natural donor cells, stem cell derived insulin responsive cells or xenogeneic cells to replace cells in the body that no longer produce the therapeutic proteins.
Sernova’s Local Immune Protection Technologies placed within the Cell Pouch™ with therapeutic cells is expected to eliminate the need for systemically administered toxic and expensive anti-rejection drugs ($10-15,000/yr).

FIRST THERAPEUTIC APPLICATION - DIABETES
The Cell Pouch™ has been contract manufactured in accordance with the strict guidelines of ISO13485, as mandated by the FDA. In preclinical safety and efficacy studies, the Cell Pouch™ with islets has been shown to be safe and to control sugar levels in small (isograft – similar cell transplants) and large animal transplantation models of diabetes including an autograft model (self-islets are placed into the Cell Pouch™) and an allograft model (donor islets are placed into the Cell Pouch™). Sernova’s technologies have been independently proven under collaboration at the University of Alberta in a marginal islet mass study showing that a small dose of islets can make diabetic animals insulin independent at the 100 day time point. Several of Sernova’s important preclinical studies have been funded in part by agencies such as the National Research Council (IRAP) of Canada. In addition to these studies, the Cell Pouch™ has been shown to be biocompatible in a series of FDA mandated preclinical studies (ISO10993).

Sernova Corp., received Health Canada Approval to conduct a Phase I/II human clinical trial assessing the safety and efficacy of Sernova's Cell Pouch™ with transplanted insulin-producing islets in patients with insulin-dependent diabetes. The primary endpoint of safety and biocompatibility has been demonstrated. Results have been presented at the International Pancreas and Islet Transplantation Association and at the 2015 American Diabetes Association Meeting. The Company is currently preparing for a U.S. clinical study of the Cell Pouch to assess efficacy in diabetes at a major transplantation center.

ADDITIONAL PRODUCT OPPORTUNITIES/PARTNERING/M&A
Sernova is also developing its local immune technologies to reduce or eliminate the need for antirejection regimens. Furthermore, with the success of the Cell Pouch™ to date, Sernova is developing technologies to provide an unlimited source of locally immune protected cells including stem cell derived insulin responsive cells and xenogeneic cells to treat the 50M patients currently taking insulin worldwide.

The Company is currently also developing a product for Haemophilia A as member of a European Consortium (HemAcure) which has recently received approximately 5.6M EU ($8.5M CAD) funding from the European Union with a successful, highly prestigious European Union Horizon 2020 grant. The grant is to develop the product for clinical trials in patients with Hemophilia A and is expected to reduce or eliminate the need for multiple weekly infusions of Factor VIII. The current market for Factor VIII which must be infused thrice weekly for prophylactic treatment is approximately $5.0B/yr. Sernova plans to develop other indications using the Cell Pouch System™ to treat diseases such as Thyroid disease, with approximately 250,000 patients/yr who could benefit from a cell therapy approach. The company is seeking corporate partners for these therapies and plans to in-license additional complementary technologies.

SERNOVA’S MANAGEMENT/BOARD/ADVISORY BOARD

Management Team: President and CEO since May 2009 – Dr. Philip Toleikis: Former VP Pharmacology R&D, Angiotech Pharmaceuticals, where he was part of the team that developed the multi-billion dollar drug-eluting stent and other drug-eluting medical devices; Chief Financial Officer, Ralph Deiterding: CPA, CA, CMA is a finance veteran with over 20 years of experience, primarily in senior finance roles at Toronto Stock Exchange listed software vendors; Senior Director R&D - Delfina Siroen: BSc. Hon. MSc. with over 20 years in managing academic and corporate R&D teams; Business Development – Nick Borrelly: 25 years corporate development (Ciba-Geigy, Novartis and Sanofi-Aventis).

Board of Directors: Chairman Frank Holler – CEO and partner BC Advantage Funds; Jeffery Bacha – CEO Delmar Pharmaceuticals, Inc.; Bruce Weber – V.P Clinical, Regulatory and QA Innovia LLC; James Parsons, CA; Dr. Philip Toleikis, President and CEO Sernova Corp.

As Servova approaches near-future catalysts, this clinical stage regenerative medicine company is poised to a become a ‘difference maker’ for millions of patients globally suffering from Diabetes and Hemophilia. For a quick cursory read, please clickhttp://www.sernova.com/pdf/Sernova%20Corp%20Fact%20Sheet%202015.pdf.

[StruckGold]

Sernova Corp is a clinical stage company, developing highly disruptive platform technologies to treat chronic diseases through a regenerative medicine approach. Sernova’s primary focus is in developing technologies for the treatment of patients with insulin-dependent (TI) diabetes, and haemophilia A.

Sernova’s novel approach uses therapeutic cells placed into an implanted medical device to produce proteins or hormones which are in short supply or missing from the body due to the underlying disease state. The Cell Pouch System™, is an implantable, scalable medical device about the size of a business card which provides a natural “organ-like” environment for the long term survival and function of therapeutic cells such as insulin producing islets to treat diabetes. The Therapeutic Cells placed into the device may be natural (human) donor cells, or cells that can be a source to treat millions of patients including stem cell derived insulin responsive cells or xenogeneic cells. Sernova uses proprietary local immune protection technologies which protect therapeutic cells within the Cell Pouch™ from immune system attack reducing or eliminating the need for daily anti-rejection drugs. Sernova’s approach is designed to make future therapeutic cell replacement a simple outpatient procedure that can be performed in virtually any hospital setting. Using a medical device and therapeutic cell strategy to treat chronic diseases, Sernova is positioned for significant revenue upon commercialization of its “disruptive paradigm-shifting” platform technology.

Sernova’s team is focused on development of the Cell Pouch System™ for diabetes to treat both Type-1 and Type-2 patients who become insulin dependent – representing a treatable population of an estimated 50M patients worldwide currently taking insulin within Sernova’s patented countries. Sernova is also focused on development of the Cell Pouch System™ for the treatment of Hemophilia A through use of corrected patient’s cells placed in the Cell Pouch™ which is then expected to release Factor VIII at a constant rate.

TECHNOLOGY HIGHLIGHTS

The Standard of Care for patients with reduced or missing critical hormones or proteins such as insulin is often monitoring blood levels and injecting these proteins multiple times a day with a consequence of poor compliance and serious side effects resulting in over $150B/yr hospital costs for diabetes alone. Cell therapy is an alternative for patients with chronic diseases; however, there is no currently approved device to house and protect these cells in the body and no method to make the therapy a simple outpatient procedure. Instead, often cells are injected multiple times into blood vessels in an extremely expensive (>$100,000) and risky procedure, where many cells die through blood-derived inflammation and clotting, resulting in the need for repeat operations. Hence, the current standard of care for local cell therapy is limited by expensive procedures, poor cell survival and inappropriate delivery coupled with a lack of donors.
Sernova’s Cell Pouch System™ is a versatile, scalable implantable medical device made of materials approved for permanent use in the body, designed by biomedical engineers and biologists. Placed under the skin or in other locations, it develops organ-like characteristics (including vascularization) for survival and long term function of therapeutic cells. A natural environment where therapeutic cells are housed within a tissue matrix, rich in microvessels is expected to conserve cell number, and promote natural function - increasing cell survival, while significantly increasing the number of treatable patients beyond those with severe disease.
Sernova’s Therapeutic Cell technologies involve the use of natural donor cells, stem cell derived insulin responsive cells or xenogeneic cells to replace cells in the body that no longer produce the therapeutic proteins.
Sernova’s Local Immune Protection Technologies placed within the Cell Pouch™ with therapeutic cells is expected to eliminate the need for systemically administered toxic and expensive anti-rejection drugs ($10-15,000/yr).

FIRST THERAPEUTIC APPLICATION - DIABETES
The Cell Pouch™ has been contract manufactured in accordance with the strict guidelines of ISO13485, as mandated by the FDA. In preclinical safety and efficacy studies, the Cell Pouch™ with islets has been shown to be safe and to control sugar levels in small (isograft – similar cell transplants) and large animal transplantation models of diabetes including an autograft model (self-islets are placed into the Cell Pouch™) and an allograft model (donor islets are placed into the Cell Pouch™). Sernova’s technologies have been independently proven under collaboration at the University of Alberta in a marginal islet mass study showing that a small dose of islets can make diabetic animals insulin independent at the 100 day time point. Several of Sernova’s important preclinical studies have been funded in part by agencies such as the National Research Council (IRAP) of Canada. In addition to these studies, the Cell Pouch™ has been shown to be biocompatible in a series of FDA mandated preclinical studies (ISO10993).

Sernova Corp., received Health Canada Approval to conduct a Phase I/II human clinical trial assessing the safety and efficacy of Sernova's Cell Pouch™ with transplanted insulin-producing islets in patients with insulin-dependent diabetes. The primary endpoint of safety and biocompatibility has been demonstrated. Results have been presented at the International Pancreas and Islet Transplantation Association and at the 2015 American Diabetes Association Meeting. The Company is currently preparing for a U.S. clinical study of the Cell Pouch to assess efficacy in diabetes at a major transplantation center.

ADDITIONAL PRODUCT OPPORTUNITIES/PARTNERING/M&A
Sernova is also developing its local immune technologies to reduce or eliminate the need for antirejection regimens. Furthermore, with the success of the Cell Pouch™ to date, Sernova is developing technologies to provide an unlimited source of locally immune protected cells including stem cell derived insulin responsive cells and xenogeneic cells to treat the 50M patients currently taking insulin worldwide.

The Company is currently also developing a product for Haemophilia A as member of a European Consortium (HemAcure) which has recently received approximately 5.6M EU ($8.5M CAD) funding from the European Union with a successful, highly prestigious European Union Horizon 2020 grant. The grant is to develop the product for clinical trials in patients with Hemophilia A and is expected to reduce or eliminate the need for multiple weekly infusions of Factor VIII. The current market for Factor VIII which must be infused thrice weekly for prophylactic treatment is approximately $5.0B/yr. Sernova plans to develop other indications using the Cell Pouch System™ to treat diseases such as Thyroid disease, with approximately 250,000 patients/yr who could benefit from a cell therapy approach. The company is seeking corporate partners for these therapies and plans to in-license additional complementary technologies.

SERNOVA’S MANAGEMENT/BOARD/ADVISORY BOARD

Management Team: President and CEO since May 2009 – Dr. Philip Toleikis: Former VP Pharmacology R&D, Angiotech Pharmaceuticals, where he was part of the team that developed the multi-billion dollar drug-eluting stent and other drug-eluting medical devices; Chief Financial Officer, Ralph Deiterding: CPA, CA, CMA is a finance veteran with over 20 years of experience, primarily in senior finance roles at Toronto Stock Exchange listed software vendors; Senior Director R&D - Delfina Siroen: BSc. Hon. MSc. with over 20 years in managing academic and corporate R&D teams; Business Development – Nick Borrelly: 25 years corporate development (Ciba-Geigy, Novartis and Sanofi-Aventis).

Board of Directors: Chairman Frank Holler – CEO and partner BC Advantage Funds; Jeffery Bacha – CEO Delmar Pharmaceuticals, Inc.; Bruce Weber – V.P Clinical, Regulatory and QA Innovia LLC; James Parsons, CA; Dr. Philip Toleikis, President and CEO Sernova Corp.

As Servova approaches near-future catalysts, this clinical stage regenerative medicine company is poised to a become a ‘difference maker’ for millions of patients globally suffering from Diabetes and Hemophilia. For a quick cursory read, please clickhttp://www.sernova.com/pdf/Sernova%20Corp%20Fact%20Sheet%202015.pdf.