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Rexahn Pharmaceuticals, Inc. (RNN)

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Last Post: 9/18/2017 11:57:31 PM - Followers: 219 - Board type: Free - Posts Today: 0




Rexahn Pharmaceuticals Inc. (NYSE MKT: RNN) is a clinical stage biopharmaceutical company focused on developing best-in-class therapeutics for the treatment of cancer. Rexahn’s clinical development programs directly target specific proteins that are selectively expressed in human cancer cells, resulting in increased efficacy and reduced toxicity. In preclinical studies these drug candidates are effective against multiple drug resistant cancers and have shown to increase the effectiveness of various FDA approved cancer treatments. Rexahn is also developing specific biomarker tests that will help identify which patients will be most responsive to its treatments. The Company’s nanotechnology-based drug delivery system has shown it can make FDA approved chemotherapy drugs more effective.

Our clinical development pipeline consists of three novel compounds:

Archexin® is a unique anti-sense drug candidate that specifically targets the cancer cell signaling protein Akt-1. Archexin is the only specific inhibitor of Akt-1 in clinical development. The activated form of Akt-1, which is involved in cancer cell growth, survival, angiogenesis, and drug resistance, has been shown to be present or elevated in more than 12 different human cancer cell lines, including pancreatic and renal cell carcinoma. By inhibiting Akt-1, Archexin has shown to inhibit the growth of human renal cell carcinoma cell lines and exhibit a longer survival benefit in the human renal cell carcinoma animal xenograft model. Thus, while Akt-1 is a very specific anti-cancer target, it may have broad therapeutic potential across multiple types of cancer.

RX-3117 is a next generation, orally bioavailable nucleoside analog that is activated (phosphorylated) by the enzyme Uridine Cytidine Kinase 2 (UCK2) and inhibits both DNA and RNA synthesis which induces apoptotic cell death of tumor cells. UCK2 is overexpressed in multiple human tumors, but has a very limited presence in normal tissues. This unique specificity for cancer cells may lead to an improved efficacy and safety profile in cancer patients. This profile differs from existing nucleoside compounds (such as the widely used chemotherapy gemcitabine), which are activated by the enzyme DCK which is expressed in both cancer cell and in normal healthy tissue leading to significant toxicities at therapeutic doses. RX-3117 has demonstrated broad spectrum anti-tumor activity against 100 different human cancer cell lines (including Non-Small Cell Lung Cancer (NSCLC), breast, ovarian, pancreas, colon, renal, brain, bladder, cervical) and efficacy in 17 different mouse xenograft models (including colorectal, non-small cell lung, pancreatic and renal cell carcinoma) superior to that of gemcitabine.

Supinoxin (RX-5902) is an orally administered, first-in-class, small molecule inhibitor of phosphorylated-p68 (P-p68). P-p68, which is selectively expressed in cancer cells and is absent in normal tissue, increases the activity of multiple cancer related genes including cyclin D1, c-jun and c-myc, and plays a role in tumor progression and metastasis. Over-expression of P-p68 has been observed in solid tumors, such as melanoma, colon, ovarian and lung.

These clinical development programs are part of a growing oncology drug pipeline that consists of highly differentiated and exciting anti-cancer compounds.

Our strategy is to continue building a significant clinical development pipeline of innovative therapies that we will commercialize on our own or with other pharmaceutical partners. Rexahn’s powerful discovery engine and differentiated product pipeline provide the opportunity for a high value generating biopharmaceutical company.


 Rexahn  Pipeline


Management Team

Peter Suzdak, Ph.D.
Chief Executive Officer 

Dr. Peter Suzdak joined Rexahn Pharmaceuticals in February 2013. Dr. Suzdak has over 25 years of diverse experience, including several management positions, in the pharmaceutical industry. Most recently, Dr. Suzdak was Chief Scientific Officer of Corridor Pharmaceuticals, a company developing small molecule compounds to treat pulmonary and vascular disorders. Prior to Corridor Pharmacueitcals, he was co-Founder, Chief Executive Officer and Chief Scientific Officer of Cardioxyl Pharmaceuticals, a company focused on therapies for the treatment of cardiovascular disease. Previous to Cardioxyl Pharmaceuticals, he was President and Chief Executive Officer of Artesian Therapeutics, a company engaged in the development of small molecule therapeutics for cardiovascular diseases. Dr. Suzdak’s experience also includes his position as Senior Vice President of Research and Development of Guilford Pharmaceuticals, a company that developed therapeutics and diagnostics for neurological diseases and cancer, and as Director of Neurobiology for Novo Nordisk. Dr. Suzdak holds a Ph.D. in pharmacology and toxicology from the University of Connecticut.

Rick Soni, MBA
President and Chief Operating Officer

Rick Soni joined Rexahn in 2008 with over 20 years of sales, marketing, product planning and business development experience in the pharmaceutical industry. Prior to joining Rexahn, Mr. Soni held leadership roles at Otsuka America Pharmaceuticals, Inc., with responsibility for commercial development, corporate strategy and execution of licensing and acquisition of therapeutics, diagnostics and medical devices. Previously, Mr. Soni has held a variety of management positions at Novartis and Schering-Plough. Mr. Soni has a BS from the University of Wisconsin-Madison and an MBA from Fairleigh Dickinson University.

Tae Heum (Ted) Jeong, D. Mgt.
Sr. Vice President  and Chief Financial Officer

Dr. Jeong has been Chief Financial Officer of Rexahn Pharmaceuticals since 2002. He oversees all aspects of capital raising, accounting, operations, and corporate development for Rexahn. He is also responsible for investor relations, and played a key role in Rexahn’s 2008 listing on the New York Stock Exchange (NYSE) AMEX. For the past 16 years, he has extensive experience in venture capital and investment banking industry that includes role at Hyundai Venture Investment Corporation where he managed the Biotechnology investment team. Dr. Jeong holds a Doctor of Management from University of Maryland and an M.S. in Finance from Johns Hopkins University

Roth Capital Partners, LLC
      Joseph Pantginis, Ph.D.

Maxim Group, LLC
Echo He, MD, Ph.D.

H. C. Wainwright & Co., LLC
Andrew Fein

Tricia Truehart
(646) 378-2953

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RNN News: Current Report Filing (8-k) 09/01/2017 09:17:58 AM
RNN News: Statement of Changes in Beneficial Ownership (4) 08/16/2017 04:06:49 PM
RNN News: Quarterly Report (10-q) 08/04/2017 04:19:01 PM
RNN News: Notice of Effectiveness (effect) 07/12/2017 06:01:44 AM
RNN News: Securities Registration Statement (simplified Form) (s-3/a) 07/06/2017 04:29:31 PM
#3724   Would be nice to see this one bounce Walterwhite666 09/18/17 11:57:31 PM
#3723   Only 23 million float stock should be much otcempire 09/15/17 12:12:01 AM
#3722   RNN Up $0.29 in Pre-Market! n3m3sis 09/11/17 08:40:43 AM
#3721   NEWS!!! "Rexahn Pharmaceuticals Presents Preliminary Efficacy Data from n3m3sis 09/11/17 05:38:27 AM
#3720   Presentation Monday: Woulfe 09/06/17 03:18:20 PM
#3719   Nice action n no posts looks like ttubular 09/06/17 09:12:05 AM
#3718   Have a Happy Retirement Dr AHN and Thank You! n3m3sis 09/01/17 09:36:37 AM
#3717   * * $RNN Video Chart 08-29-17 * * ClayTrader 08/29/17 04:24:47 PM
#3716   Rexahn Pharma up 27% on new U.S. nanoparticle Woulfe 08/29/17 03:49:13 PM
#3715   Patent news. Burkie 08/29/17 03:45:30 PM
#3714   Nice move...but... We're still trading only at 25-cents pre-split!! Lone Wolf 08/29/17 03:40:15 PM
#3713   It's alive! Head fake manipulation or some good Woulfe 08/29/17 03:38:16 PM
#3712   Y the big move today? I don't c ttubular 08/29/17 03:21:05 PM
#3711   Last post 20 days ago. AUaft 08/29/17 11:45:35 AM
#3710   The cash burn rate is at its highest slmlrd 08/09/17 10:33:05 AM
#3709   YA, WE SURE GOT TAKEN TO THE CLEANERS henery8th 08/04/17 12:32:54 PM
#3708   Excellent article well worth reading. Thank you the gipper 08/03/17 08:07:44 AM
#3707   We need some positive news to stop the bleeding ttubular 08/02/17 02:40:36 PM
#3706   Remember .135 last year?? slmlrd 08/02/17 12:58:09 PM
#3705   Not so..... n3m3sis 08/01/17 11:00:13 PM
#3704   ttubular: reverse Split back fired hanging on data HSTN 08/01/17 03:26:10 PM
#3703   Why is this stock so weak lately? ttubular 08/01/17 02:25:56 PM
#3702   Illegal Naked Short Selling Appears to Lie at n3m3sis 07/28/17 11:18:15 AM
#3701   Whatever happened to this stock? Seemed like they otcempire 07/24/17 11:36:11 AM
#3700   We're movin!! $RNN Lone Wolf 07/17/17 09:34:35 AM
#3699   Low-fiat, big short interest. This one likes Lone Wolf 07/14/17 04:18:55 PM
#3698   Rexahn Pharmaceuticals Receives Notice of Allowance for a crudeoil24 07/14/17 03:45:14 PM
#3697   Looking good for next week. Looks like Lone Wolf 07/14/17 03:42:27 PM
#3696   I learned a long time ago that if AUaft 07/10/17 09:40:46 PM
#3695   lol how's that working for you, there is Woulfe 07/03/17 10:47:02 AM
#3694   Really? Look again. LoL n3m3sis 06/29/17 04:21:44 PM
#3693   No floor. R.I.P. Longs Woulfe 06/29/17 01:44:14 PM
#3692   They've withheld Archexin data. It should have BioManRandy 06/16/17 02:13:54 AM
#3691   What would make u think it would be ttubular 06/15/17 05:43:03 PM
#3690   Really! Lol. Pittkid 06/15/17 04:08:56 PM
#3689   Archexin data should be released this Monday or BioManRandy 06/15/17 03:40:36 PM
#3688   Rinse and repeat. Down it goes under a slmlrd 06/12/17 09:59:59 AM
#3687   So the warrants for this offering are exercisable Woulfe 06/07/17 09:17:47 AM
#3686   $3.30 offering no shorts 06/07/17 09:17:00 AM
#3685   Very good update on rx3117 n we And ttubular 06/05/17 01:20:18 PM
#3684   Fear selling on the morning. Raid. I expect Woulfe 06/05/17 09:54:59 AM
#3683   GM RNN. Let's break 5 today and keep no shorts 06/05/17 08:39:25 AM
#3682   Indeed! There are a few biopharm companies that could n3m3sis 06/05/17 07:46:09 AM
#3681   Fantastic data! RNN attracting worldwide attention on the gipper 06/05/17 07:29:51 AM
#3680   Rexahn Pharmaceuticals Presents Preliminary Efficacy Data from the n3m3sis 06/04/17 05:55:47 PM
#3679   An offering is coming very soon to take Woulfe 06/04/17 02:15:44 PM
#3678   All positive news Roesi84 06/04/17 01:40:37 PM
#3677   Indeed!!Cant wait !Long and strong Rodney213 06/03/17 02:58:23 PM
#3676   Yesterdays action revealed lots of interested parties following the gipper 06/03/17 11:33:53 AM
#3675   Wall was put up at $1.30 and price no shorts 06/02/17 03:16:27 PM