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LATEST NEWS UPDATE 


**********08/20/2020**********
 

Rapid Recovery from COVID-19 Respiratory Failure with Comorbidity in 21 Patients Treated with Vasoactive Intestinal Peptide


https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3665228


 

8 PagesPosted: 4 Aug 2020Last revised: 20 Aug 2020

Jihad G. Youssef

Houston Methodist Research Institute

Mukhtar Al-Saadi

Houston Methodist Hospital

Faisal Zahiruddin

Houston Methodist Hospital

Sarah Beshay

affiliation not provided to SSRN

Mohammad Bitar

affiliation not provided to SSRN

Jonathan Javitt

Johns Hopkins School of Medicine

Date Written: August 20, 2020

Abstract

Background: Vasoactive Intestinal Peptide (VIP) is known to bind to and protect Alveolar Type II cells by blocking replication of the SARS-CoV-2 virus, inhibiting cytokine synthesis, preventing cytopathy, and upregulating surfactant production. RLF-100™ (aviptadil), a synthetic form of VIP has been granted Fast Track Designation for treating Critical COVID-19 with Respiratory Failure and is currently in phase 2/3 placebo-controlled trials. 

Methods: Case series of 21 consecutive patients with Acute Respiratory Failure in Critical COVID-19 and multiple co-morbidities, treated with intravenous VIP. Sixteen patients were treated with mechanical ventilation and five with extracorporeal membrane oxygenation (ECMO).

Results: So far, 19 of 21 patients have survived. Improved radiographic appearance was seen in both lungs of 17 patients and in one lung of 2 patients. A mean 292% increase in PaO2:FiO2 ratio was seen with complete remission from respiratory failure in 9 patients and ongoing improvement in 10. Seven patients were discharged from the hospital, 7 sent to intermediate care, and 5 remain in the ICU. Three of 5 patients on ECMO have been decannulated and two have been discharged. A 75% (95% CI±3%: P<.001) reduction in IL-6 was seen with corresponding decrease in C-reactive protein. A median 4 point reduction in the NIAID Ordinal Scale was observed (P<.01).  

Comment: The short term outcomes in these 21 patients represent a dramatic response in patients who are excluded from all other trials of COVID therapeutics. Improvement in radiographic appearance, oxygenation requirement, and inflammatory markers is consistent with in vitro evidence of direct anti-viral effect.
 

 

Note: Funding: Funding:Research support was provided by the Cavendish Impact Foundation. Clinical trial funding was provided by Relief Therapeutics Holdings, AG, Geneva, which holds intellectual property related to the pharmacologic use of Aviptadil. 

Conflict of Interest: Author JCJ is employed bya pharmaceutical company that is currently conducting clinical trials of RLF-100in patients with COVID-19 and has a financial interest in the outcome of those clinical trials. Author MJJ was paid for medical writing by NeuroRx, Inc. Author JGY has received funding as an investigator for RLF-100 through his institution. 

Ethical Approval: Human subjects protection was overseen by the Institutional Review Board (IRB) of the Houston Methodist Hospital. 

Keywords: VIP, vasoactive intestinal peptide, aviptadil, SARS-CoV-2, corona virus, COVID-19, respiratory failure, IL6, ARDS



*********************************
Previous News
 

RLF-100 (aviptadil) clinical trial showed rapid recovery from respiratory failure and inhibition of coronavirus replication in human lung cells

August 2, 2020, 4:00 PM

- Rapid recovery of patients on ventilators and ECMO (extracorporeal membrane oxygenation) was seen in patients with severe medical comorbidities after three days of treatment with RLF-100 under FDA Emergency Use IND authorization at multiple clinical sites

- Aviptadil is being developed as the first COVID therapeutic to block replication of the SARS-CoV-2 virus in human lung cells and monocytes

- RLF-100 is a patented formulation of aviptadil (synthetic human Vasoactive Intestinal Polypeptide VIP), which has been granted FDA Fast Track Designation, FDA emergency use IND authorization, and an expanded access protocol

https://finance.yahoo.com/news/rlf-100-aviptadil-clinical-trial-200000564.html



REUTERS
https://www.nytimes.com/reuters/2020/08/06/world/europe/06reuters-health-coronavirus-relief-hldg.html

Relief Therapeutics sees 60-70% chance of COVID-19 drug approval

AUGUST 8, 2020 / 2:52 AM
https://www.reuters.com/article/us-health-coronavirus-relief-hldg/relief-therapeutics-sees-60-70-chance-of-covid-19-drug-approval-idUSKCN25409K

ZURICH (Reuters) - Relief Therapeutics’ chairman said he was optimistic its RLF-100 (aviptadil) drug will win approval for treating COVID-19 patients in a matter of months.

The Swiss group owns the rights to the drug in the United States and Europe. Its U.S. partner NeuroRx is running multicentre clinical trials here including a Phase IIb/III trial in patients who are severely ill because of the consequences of COVID-19, the respiratory disease caused by the new coronavirus.

“The active pharmaceutical ingredient of aviptadil has been used for a lot of years in different indications. From a safety standpoint we are quite optimistic,” Raghuram Selvaraju told Swiss newspaper The Market in an interview posted late on Friday.

“From an efficacy standpoint we need more data. I would say the probability at the moment stands at 60 to 70% that we will get the drug approved,” he added.

 

New York Times

https://www.nytimes.com/reuters/2020/08/06/world/europe/06reuters-health-coronavirus-relief-hldg.html

FDA Lets NeuroRx, Relief Therapeutics Test RLF-100 in COVID-19 Patients

By Reuters

Aug. 6, 2020, 12:51 a.m. ET
  • ZURICH — The U.S. Food and Drug Administration has granted NeuroRx Inc Investigational New Drug (IND) permission to test RLF-100 (aviptadil) for inhaled use in patients with moderate and severe COVID-19 to prevent progression to respiratory failure, it and partner Relief Therapeutics Holdings said on Thursday.

The clinical trial of the inhaled formulation of RLF-100 is expected to begin on or before Sept. 1, a joint statement said.

They said aviptadil is shown as the first COVID therapeutic to block replication of the SARS-CoV-2 virus in human lung cells and monocytes while also preventing synthesis of cytokines in the lung. It is a patented formulation of aviptadil (synthetic human Vasoactive Intestinal Polypeptide, VIP), which has been granted FDA fast track designation, FDA emergency use IND authorisation, and an expanded access protocol.

(Reporting by Michael Shields; editing by Thomas Seythal)

 

Research Paper out from JohnHopkins,Houston Methodist Hospital and
New York University (NYU) - Langone Medical Center

Rapid Recovery from COVID-19 Respiratory Failure after treatment with Vasoactive Intestinal Peptide
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3665228


RLF-100 (aviptaadil) Clinical Trail - FastTrack COVID drug
https://clinicaltrials.gov/ct2/results?term=Aviptadil&draw=2&rank=1#rowId0



FOX BUISENESS VIDEO INTERVIEW (FEATURED ON FOX CABLE NEWS!!!!)
 https://video.foxbusiness.com/v/6178856365001/#sp=show-clips
Drug that gives fellas a lift in the bedroom may also beat Covid, experts believe
https://www.thesun.co.uk/news/12324918/erectile-dysfunction-drug-may-beat-covid/
Fox News Affiliate Coverage on drug Aviptadil/RLF-100
https://www.fox10tv.com/news/covid-cases-rise-double-digits-instead-of-triple-digits-in-mobile-county/article_6c0760dc-d691-11ea-b98b-930282e20fbe.html
NEW YORK TIMES COVERAGE
https://www.nytimes.com/reuters/2020/08/03/world/europe/03reuters-health-coronavirus-relief-hldg-neurorx.html
REUTERS COVERAGE
https://www.reuters.com/article/us-health-coronavirus-relief-hldg-neuror/relief-neurorx-say-emergency-treatment-with-rlf-100-helps-critically-ill-covid-patients-idUSKBN24Y0OR
NY POST COVERAGE
https://nypost.com/2020/08/02/relief-neurorx-rlf-100-helps-critical-covid-19-patients/
TIMES OF ISRAEL COVERAGE
https://www.timesofisrael.com/erectile-dysfunction-drug-shows-promise-treating-covid-israeli-innovator-says/




Dr. Yo talks the science behind RFL-100 in latest video.
https://twitter.com/YoDoctorYo/status/1292559532313292802?s=20
https://www.pscp.tv/w/1ynJOqkBWZkKR


 


 

 

 

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PostSubject
#21200  Sticky Note And as someone else has pointed out, here's Uncle Gee Gee 09/17/20 03:37:27 PM
#20297  Sticky Note The LifeScience video and the CEO Roundtable video Uncle Gee Gee 09/12/20 11:18:38 PM
#13538  Sticky Note Trump knows some big drugs are about to Uncle Gee Gee 08/23/20 10:28:32 PM
#3516  Sticky Note $RLFTF Phase II study where inhaled Aviptadil was Andy2018 08/09/20 06:50:41 PM
#22892   This should be at $1.50 right now... 07up 09/25/20 06:10:44 PM
#22891   Wish I had seen it. That's wonderful. Great guy. tiggerifficm4 09/25/20 06:00:05 PM
#22890   Slides of Dr. Javitt's keynote. https://www.facebook.com/groups/145235114497532 tiggerifficm4 09/25/20 05:59:22 PM
#22889   nicole Wallace on MSNBC just did a tribute aGuyUS 09/25/20 05:57:22 PM
#22888   Ban him massulo52 09/25/20 05:47:17 PM
#22887   Todays video Trading is fun 09/25/20 05:47:03 PM
#22886   Comn Moderators read the post... It's not just aGuyUS 09/25/20 05:35:59 PM
#22885   They will have to show they have a Toohie 09/25/20 05:34:55 PM
#22884   Re: "You're betting money on an inhaler? Why?" elllk 09/25/20 05:30:37 PM
#22878   hoping for one buck....then ride up to 20 bucks. JUST 10-11-12 09/25/20 04:46:54 PM
#22877   Get your facts straight. Very disrespectful. tiggerifficm4 09/25/20 04:39:46 PM
#22873   ETRADE and iHub show we closed at .5985...awesome!!! The Whale 09/25/20 04:28:27 PM
#22872   We sure did! This has been one hell RockstarStocks 09/25/20 04:27:40 PM
#22871   Have a great weekend, everyone!!! The Whale 09/25/20 04:25:37 PM
#22870   This is our time...we earned it!!! The Whale 09/25/20 04:22:58 PM
#22869   59...love it!!! The Whale 09/25/20 04:00:32 PM
#22868   Alright gang... great week! Thanks for everyone's Uncle Gee Gee 09/25/20 03:59:50 PM
#22867   Last Call... you're either in or out :) Uncle Gee Gee 09/25/20 03:58:58 PM
#22866   I'm happy...period...next week we go parabolic...70's will be The Whale 09/25/20 03:57:24 PM
#22864   I responded aGuyUS 09/25/20 03:55:54 PM
#22863   Beautiful!!! OTC have fire this week! $RLFTF’s turn! RockstarStocks 09/25/20 03:55:04 PM
#22862   Hahaha... no doubt. That $.62 would be Uncle Gee Gee 09/25/20 03:53:32 PM
#22861   LOL...I know right :) The Whale 09/25/20 03:51:45 PM
#22860   I know Soo sad BUT on a lighter note!!!!... aGuyUS 09/25/20 03:51:01 PM
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#22858   More like insane. The Whale 09/25/20 03:47:46 PM
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#22856   I'm in where is your massulo52 09/25/20 03:46:37 PM
#22855   Good job, Max :) The Whale 09/25/20 03:46:04 PM
#22854   Let em burn RockstarStocks 09/25/20 03:45:27 PM
#22853   The music in the club is pump'n and Uncle Gee Gee 09/25/20 03:44:58 PM
#22852   News will hit the wires any moment. Make Andy2018 09/25/20 03:44:45 PM
#22851   Mms should just drop it to zero to Tiger Money 09/25/20 03:44:37 PM
#22850   to late its gone,,,lol massulo52 09/25/20 03:42:25 PM
#22846   THE GAMES THEY PLAY SO SAD!!!! massulo52 09/25/20 03:38:37 PM
#22845   Kiss MAH SIXTY TWO..PLEASE...KISS IT...KISS ITTTTTTTTTTTTTT aGuyUS 09/25/20 03:37:19 PM
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#22843   It would be EXTREMELY DANGEROUS to be short Uncle Gee Gee 09/25/20 03:34:03 PM
#22841   Huge BIDs popping up...News leak...it's coming. The Whale 09/25/20 03:30:45 PM
#22840   Another political hit piece against Harris. This nelskof 09/25/20 03:29:48 PM
#22838   Don’t miss the only covid CURE “therapy” drug. $RLFTF Andy2018 09/25/20 03:24:21 PM
#22837   Where r those typical guys?? Hahaha Andy2018 09/25/20 03:23:22 PM
#22836   O ye of little faith The Whale 09/25/20 03:21:17 PM
#22835   40 mins before close for the weekend. Pcilliterate 09/25/20 03:20:11 PM
#22834   Okay whoever is playing games with th SP, Sapientlife 09/25/20 03:18:16 PM
#22833   Don’t worry the mms will walk it down Tiger Money 09/25/20 03:14:59 PM
#22832   TD Ameritrade has charged my a $15 daily Pcilliterate 09/25/20 03:13:39 PM
#22831   Agree.. fundamentals trump technicals.. cybermich 09/25/20 03:12:24 PM
#22830   60weeeeeeeeeeeeeeeeeeeweeeeee aGuyUS 09/25/20 03:12:20 PM
#22829   OMG...now that's a scary thought The Whale 09/25/20 03:10:58 PM
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