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Last Post: 3/11/2020 10:44:45 AM - Followers: 44 - Board type: Free - Posts Today: 0


Dr. Frost's brilliance

Dr. Frost was chairman at Mt. Sinai Medical Center in Florida and a consultant at Miles Laboratories when he met the manager, Michael Jaharis. They learned of a pharmaceutical company that had just lost $700,000 and couldn't afford to bring out a new drug.

Dr. Frost figured they could customize a new delivery system to effectively speed past the typical decade-plus drug commercialization route involving tens of millions of dollars. He invested $50,000 in the company, Key Pharmaceuticals, and found a new way of delivering an existing drug into the body.

Next, Dr. Frost and Mr. Jaharis took on a crotchety asthma medication. Theophylline was a little-used older drug, ineffective in small doses but toxic in large doses. So, Key researchers devised a way to incorporate the drug into a 12-hour time-release pill.

Blessed with good luck and good leadership, Key continued its unique pathway. The company didn't have the roughly $30,000 needed to test the pill but The University of Florida agreed to test it and publish the results. Rather than spending a lot of money on marketing, Key offered allergists pill samples backed by scientific data and a calculator to figure accurate dosage.

With successful drugs marketed, agreements with larger pharmaceutical companies followed. The realization hit the partners in 1986: They had, indeed, found the key to building a $50,000 straggler into a behemoth. They sold Key Pharmaceuticals to Schering-Plough for $800 million.

In 1987, Dr. Frost jiggled the key to open up the potential of generic products company Ivax. The company became the world's largest maker of low-priced copies of brand drugs whose patents had expired. The business was tough and disheartening at times - like the time a lucrative Norwegian merger fell apart in 1995. But Dr. Frost shoved away that disappointment.

He sold the business in 2005 to Teva Pharmaceutical Industries for a cool $7.6 billion.

The doctor from Miami Beach, Fla. continued his magic as he began building Opko Health in 2007. Today, the pharmaceutical and diagnostic company boasts a $4 billion market cap and a respected chief executive.

"Every company we've built has always had skeptics," he said. "And they have always paid the price in the end."

Dr. Frost indicated OPK is targeting multiple medical markets worth about $30 billion. We wouldn't be surprised if, at some point, Dr. Frost's company becomes an acquisition target of a large pharmaceutical company searching for promising drugs to replace its drugs with expiring patents.

Insider Filings - FROST PHILLIP MD



#416   Wow! starbuxsux 03/11/20 10:44:45 AM
#415   Dr. Phillip Frost fined $5m by SEC for Wildbilly 03/09/20 09:22:25 PM
#414   https://www.cnn.com/us/live-news/hurricane-florence-dle/h_81100aaefcd4660f7964a8 alchemytrader 09/14/18 09:14:23 AM
#413   Whoa, nice chart. Wildbilly 09/12/18 12:06:01 PM
#412   LTS should be halted as well... MWM 09/12/18 11:29:09 AM
#411   SEC suit: first move in a much wider crackdown Wildbilly 09/12/18 10:40:33 AM
#410   No doubt, guy is a billionaire messing around MWM 09/11/18 12:18:17 PM
#409   SEC Charges Microcap Fraudsters for Roles in Lucrative [SMART MONEY] 09/11/18 12:05:36 PM
#408   Garbage, sorry I set up this board... MWM 09/09/18 10:16:44 AM
#407   https://www.nbcnews.com/news/us-news/florida-billionaire-phillip-frost-charged-s MWM 09/09/18 10:16:24 AM
#406   Riot BlockChain CEO John O'Rourke is out, interim MWM 09/09/18 10:11:29 AM
#405   Frost involved in P&D lawsuit - XenaLives 09/08/18 09:32:38 AM
#404   Whoop, been watching that hoping this is the Wildbilly 10/02/16 09:46:32 AM
#403   It appears the SEC is finally on his coastiretired 10/01/16 02:34:45 PM
#402   Be afraid when you see Honig in a Wildbilly 04/13/16 12:00:23 PM
#401   Another Dr. Frost Stinker coastiretired 04/13/16 11:24:18 AM
#400   SciVac SVACF RealGenius 12/02/15 03:39:09 PM
#399   CDXC: Niagen will now be in Whole Foods, kellyaemmerson 11/23/15 09:32:53 AM
#398   WOW! CDXC and P&G (Proctor & Gamble) article kellyaemmerson 11/12/15 02:38:54 PM
#397   CDXC NEWS (Doc invests and deal with P&G) kellyaemmerson 11/05/15 07:51:20 AM
#396   SVON Frost position increased 25% RealGenius 10/23/15 03:02:24 PM
#395   IDI - The Building Of An Extraordinary Business starbuxsux 10/23/15 02:56:14 PM
#394   Today's GNC news is GREAT for CDXC kellyaemmerson 10/22/15 03:14:56 PM
#393   http://investorshub.advfn.com/boards/read_msg.aspx?message_id=117912818 starbuxsux 10/22/15 01:05:40 PM
#392   http://investorshub.advfn.com/boards/read_msg.aspx?message_id=117912681 starbuxsux 10/22/15 01:01:19 PM
#391   http://investorshub.advfn.com/boards/read_msg.aspx?message_id=117910956 starbuxsux 10/22/15 12:16:10 PM
#390   I tried posting my thoughts on DIS. JLS 10/22/15 02:52:32 AM
#389   Yea, that's what I was suggesting...someplace where we starbuxsux 10/21/15 05:40:03 PM
#388   s_bux_ JLS 10/21/15 04:43:20 PM
#387   Actually since you're not a paying member I starbuxsux 10/21/15 03:28:49 PM
#386   You've had posts deleted. JLS 10/21/15 03:22:26 PM
#385   COCP, Hep C drug selected and to start UHD 10/21/15 07:53:41 AM
#384   From late September: Minding 10/13/15 01:59:49 PM
#383   ROX played well off $1 support w those RealGenius 09/24/15 08:13:32 PM
#382   SVON presented data today. No position. http://www.seviontherapeutics.com/sevio RealGenius 09/24/15 08:07:09 PM
#381   CDXC up on volume last few days. Frosts RealGenius 09/01/15 09:29:02 PM
#380   Damn there's been a lot of open market RealGenius 08/30/15 10:47:18 PM
#379   He bought another $2.5M in OPK RealGenius 08/25/15 07:56:56 AM
#378   SVON starting to move up......... rarefind 08/19/15 05:34:05 PM
#376   He added small to LTS RealGenius 08/15/15 01:33:55 PM
#375   CDXC HUMAN TRIAL RESULTS: GAME CHANGER kellyaemmerson 08/12/15 09:11:57 AM
#374   MBVX is contracted to supply JUNO. Not sure RealGenius 08/06/15 08:51:27 PM
#373   please see my earlier post of a few brooklyn13 08/06/15 04:26:55 PM
#372   I posted just now in the COCP board Minding 08/06/15 12:36:42 PM
#371   Great article on SVACF and COCP and Dr. Frost kellyaemmerson 08/05/15 04:53:24 PM
#370   Sevion Therapeutics, Inc. ("Sevion" or the "Company") (SVON) rarefind 08/03/15 03:42:03 PM
#369   KDUS: This sounds interesting and I appreciate the Minding 08/03/15 01:17:48 PM
#368   FYI SVON has one of the past top rarefind 08/03/15 01:14:18 PM
#367   SVON Frost buys more....very bullish for this tiny rarefind 08/03/15 01:07:45 PM
#366   WSJ article about Dr. Frost play DRNE rtraster 08/03/15 07:47:13 AM
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