Principal Scientist, Protein Expression and Optimization in Mammalian Systems
Neoleukin Therapeutics is seeking an exceptional Principal Scientist to lead its efforts in the field of Mammalian Protein expression. The selected candidate will participate in research programs targeting the expression, characterization, and optimization of de novo designed protein therapeutics. The scope of the research will include (but is not limited to) production of complex recombinant proteins and biochemical, biophysical, and thermodynamic characterization. Examples of targets are cytokines, cell-signaling molecules, and soluble forms of membrane cytokine receptors.
The candidate must have at least five years of industry experience in expression, purification, characterization and optimization of recombinant proteins in mammalian systems, including the expression of human antibodies, cytokines, and cytokine receptors.
The appointed scientist will be responsible for designing and managing research programs in collaboration with senior management, as well as to translate our high-level strategic vision into a scientific reality. As an early-stage biotech company, Neoleukin thrives on developing an inspiring work environment that foremost embraces a collaborative team-based approach.
- Application of existing biochemical, biophysical and thermodynamic tools for mammalian protein expression
Purification of recombinant proteins using a variety of systems (ion exchange, size exclusion, affinity chromatography)
Characterization of proteins using various methods, such as SDS-PAGE/CE-SDS, SEC-MALS, MS, and endotoxin testing
Troubleshoot and optimize assays through data interpretation, identification of novel or alternate procedures and techniques
Preparation of data summaries, reports, manuscripts, and presentations of research results
Perform experiments with strong attention to detail and excellent documentation
Determination and implementation of research team goals
Building a collaborative network within Neoleukin Therapeutics and with its external research partner
Lead a team of researchers and regularly interfacing with senior management
- Expertise in the fields of Biochemistry, Chemistry, Molecular or Cell Biology, or related fields in Life Sciences. PhD is highly desired
Substantial proven experience in generation and characterization of recombinant proteins in heterologous systems is required,
including Mammalian systems. Including: Protein Expression and Purification, Biophysics, Protein Structure determination,
Protein Biochemistry, and/or protein engineering Experience in protein analytical techniques, including electrophoresis, Western Blot, ELISAs,
Endotoxin assays, HPLC, FPLC, UV-Vis Spectrophotometry, Calorimetry (ITC/DSC), Fluorescence and Circular Dichroism Spectroscopy,
Surface Plasmon Resonance (SPR) and Mass Spectrometry Proven exceptional record of research, including peer-reviewed publications in international journals
Excellent written and oral communication and presentation skills
Ability to work in a team environment encompassing multiple disciplines with excellent interpersonal and management skills.
A strong desire to work in a highly dynamic environment is essential
Ability to work independently, multi-task and meet deadlines in a fast-paced environment
Committed to the values of integrity, scientific rigor, and transparency
Neoleukin Therapeutics is proud to be an equal opportunity employer.
All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin,
veteran or disability status, or age, and Neoleukin will not tolerate discrimination or harassment based on any of the above characteristics.