Cannabis Report
Home > Boards > US Listed > Biotechs >

Madrigal Pharmaceuticals Inc (MDGL)

MDGL RSS Feed
Add MDGL Price Alert      Hide Sticky   Hide Intro
Moderator: DMOST
Search This Board: 
Last Post: 6/18/2018 12:57:21 PM - Followers: 18 - Board type: Free - Posts Today: 0


 
WEBSITE: http://www.madrigalpharma.com


NEW MADRIGAL/SYNTA CORPORATE PRESENTATION:

http://www.madrigalpharma.com/wp-content/uploads/2016/05/Synta-Madrigal-Corporate-Slide-Deck-2060501.pdf
Madrigal Pharmaceuticals is developing novel, high-quality small-molecule drugs addressing major unmet needs in cardiovascular and metabolic diseases. The Company is targeting treatment of both niche and prevalent indications, including fatty liver disease and non-alcoholic steatohepatitis (NASH), diabetes, dyslipidemia and cardiovascular disease. Madrigal’s lead drug candidate is MGL-3196, a Phase 2 ready orally administered liver-directed thyroid hormone receptor-ß (THR-ß) agonist. In Madrigal’s 14-day multiple dose Phase 1 study in healthy volunteers with mildly elevated LDL cholesterol, MGL-3196 demonstrated safety and excellent tolerability at all doses tested. In the multiple dose study, MGL-3196 demonstrated proof-of-concept for lipid lowering including dose-dependent, highly significant, up to 30% lowering of LDL cholesterol and non-HDL cholesterol, and a strong trend of up to 60% triglyceride lowering. These results suggest that MGL-3196 has a unique lipid lowering profile as compared with other agents and a potential to significantly reduce cholesterol, triglycerides and liver triglycerides. Elevated cholesterol, triglycerides and fatty liver are an underlying cause of many metabolic and cardiovascular diseases, which, themselves, are associated with increased mortality.

In addition, MGL-3196 is a NASH target supported by compelling human biology and genetics. NASH is a serious liver disease found in individuals with fatty liver disease that is associated with hypothyroidism, diabetes, obesity, and dyslipidemia. MGL-3196 Phase 1 human data demonstrate safety and benefit in NASH-related dyslipidemia, and data from MGL-3196 treated NASH animal models support efficacy in NASH at doses relevant to humans.
 
Cannabis Report
MDGL
Current Price
Volume:
Bid Ask Day's Range
  • 1D
  • 1M
  • 2M
  • 3M
  • 6M
  • 1Y
  • 2Y
  • 3Y
  • 5Y
MDGL News: Statement of Changes in Beneficial Ownership (4) 06/13/2018 03:54:24 PM
MDGL News: Current Report Filing (8-k) 06/08/2018 04:44:31 PM
MDGL News: Prospectus Filed Pursuant to Rule 424(b)(5) (424b5) 06/07/2018 04:37:55 PM
MDGL News: Madrigal Pharmaceuticals Prices Public Offering of Common Stock 06/06/2018 11:14:22 PM
MDGL News: Prospectus Filed Pursuant to Rule 424(b)(5) (424b5) 06/06/2018 06:03:36 AM
PlusOneCoin Top Posts
No plusone'd posts yet. Be the first!
PostSubject
#96   Thanks a million...... Millions242 06/18/18 12:57:21 PM
#95   MDGL .........A quicker and more convenient way to check DMOST 06/16/18 05:56:20 AM
#94   Cash for NASH: 2 Top Biotech Takeover Targets DMOST 06/15/18 03:13:43 PM
#93   Thanx man.... It really helps when I ask Imperial Whazoo 06/15/18 12:57:02 PM
#92   Here's the link for MDGL www.gurufocus.com Millions242 06/14/18 10:52:42 PM
#91   Lots of inside selling from executives. They Millions242 06/14/18 02:37:31 PM
#90   Major Pharmaceuticals Scare Off Short Sellers DMOST 06/14/18 05:44:12 AM
#89   Sure, It's what's systematically happens when these things occur....Nothing DMOST 06/13/18 10:51:21 PM
#88   A previous post has the link....(see below) DMOST 06/13/18 10:46:51 PM
#87   good call... [SMART MONEY] 06/13/18 07:55:54 PM
#86   Well, I looked through all my news links Imperial Whazoo 06/13/18 04:09:56 PM
#85   ....And of course the rumors of a buy DMOST 06/13/18 02:51:45 PM
#84   Madrigal Pharma Is Exploring Sale After Receiving Takeover Interest DMOST 06/13/18 02:35:34 PM
#83   Let me join in and say that I Imperial Whazoo 06/13/18 12:07:52 PM
#82   True. MDGL Has been for me also, as DMOST 06/08/18 02:28:23 PM
#80   I think a 10-15% drop is very possible tomorrow T695 06/07/18 05:15:27 PM
#79   This ticker is a traders dream... long and T695 06/07/18 05:14:20 PM
#78   MARKED !...........as just another short opinion, wishin DMOST 06/07/18 05:08:27 PM
#77   They going to kill this thing tomorrow... mark T695 06/07/18 03:49:04 PM
#76   MDGL ...little viking .........And DMOST 06/07/18 01:57:59 PM
#75   MDGL will tank when Wall st. finds out greens12 06/07/18 01:43:28 PM
#74  Restored MDGL sinking while viking is going up...Pair greens12 06/07/18 01:08:28 PM
#73   New daily low coming soon T695 06/07/18 12:55:00 PM
#72   MDGL , Is it really?...Don't keep your pole in DMOST 06/07/18 12:23:20 PM
#71  Restored My Pair trade is working. Short MDGL greens12 06/07/18 11:49:06 AM
#70   Or maybe $240 T695 06/07/18 11:42:15 AM
#69   $270 seem like a good spot to cover T695 06/07/18 10:40:37 AM
#68   Not quite that low , it now seems . DMOST 06/07/18 06:48:14 AM
#66   will drop to 150.00 range with upcoming greens12 06/07/18 12:40:08 AM
#65  Restored The perfect Pair Trade short MDGL which is greens12 06/07/18 12:32:08 AM
#64   Madrigal Pharmaceuticals Announces Proposed Public Offering of Common Stock DMOST 06/06/18 09:28:08 AM
#63   BAM there’s there offering lol T695 06/05/18 06:07:38 PM
#62   Will this thing run like SAGE lol Watching T695 06/05/18 02:26:30 PM
#61   Thanks. investor86 06/04/18 11:29:13 AM
#60   TD T695 06/04/18 11:28:36 AM
#59   What broker are you using to short? Etrade investor86 06/04/18 11:03:03 AM
#58   maybe [SMART MONEY] 06/01/18 04:57:53 PM
#57   Probably will T695 06/01/18 02:44:24 PM
#56   And I problem will go short in a T695 06/01/18 02:42:28 PM
#55   C’mon I know you smarter than thinking a T695 06/01/18 02:41:49 PM
#54   279.80 just .20 less than 280 high [SMART MONEY] 06/01/18 02:37:46 PM
#53   I’m watching and waiting, I covered way too T695 06/01/18 02:34:06 PM
#52   congrats [SMART MONEY] 06/01/18 02:27:59 PM
#51   its retesting HIGHS now [SMART MONEY] 06/01/18 02:26:53 PM
#50   If it retest the high I’m shorting again T695 06/01/18 10:25:20 AM
#49   Covering.... T695 06/01/18 10:07:09 AM
#48   $280 !!!! bad fri morn for shorties [SMART MONEY] 06/01/18 08:02:54 AM
#47   More upside today > MDGL crudeoil24 06/01/18 07:52:57 AM
#46   Wish Robinhood had options on this play. I TheInvincibleBull 05/31/18 11:45:53 PM
#45   Madrigal Pharma Shares Double After Successful Phase II DMOST 05/31/18 08:50:26 PM
PostSubject