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Madrigal Pharmaceuticals Inc (MDGL)

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Last Post: 10/19/2018 4:24:02 PM - Followers: 18 - Board type: Free - Posts Today: 0


 
WEBSITE: http://www.madrigalpharma.com


NEW MADRIGAL/SYNTA CORPORATE PRESENTATION:

http://www.madrigalpharma.com/wp-content/uploads/2016/05/Synta-Madrigal-Corporate-Slide-Deck-2060501.pdf
Madrigal Pharmaceuticals is developing novel, high-quality small-molecule drugs addressing major unmet needs in cardiovascular and metabolic diseases. The Company is targeting treatment of both niche and prevalent indications, including fatty liver disease and non-alcoholic steatohepatitis (NASH), diabetes, dyslipidemia and cardiovascular disease. Madrigal’s lead drug candidate is MGL-3196, a Phase 2 ready orally administered liver-directed thyroid hormone receptor-ß (THR-ß) agonist. In Madrigal’s 14-day multiple dose Phase 1 study in healthy volunteers with mildly elevated LDL cholesterol, MGL-3196 demonstrated safety and excellent tolerability at all doses tested. In the multiple dose study, MGL-3196 demonstrated proof-of-concept for lipid lowering including dose-dependent, highly significant, up to 30% lowering of LDL cholesterol and non-HDL cholesterol, and a strong trend of up to 60% triglyceride lowering. These results suggest that MGL-3196 has a unique lipid lowering profile as compared with other agents and a potential to significantly reduce cholesterol, triglycerides and liver triglycerides. Elevated cholesterol, triglycerides and fatty liver are an underlying cause of many metabolic and cardiovascular diseases, which, themselves, are associated with increased mortality.

In addition, MGL-3196 is a NASH target supported by compelling human biology and genetics. NASH is a serious liver disease found in individuals with fatty liver disease that is associated with hypothyroidism, diabetes, obesity, and dyslipidemia. MGL-3196 Phase 1 human data demonstrate safety and benefit in NASH-related dyslipidemia, and data from MGL-3196 treated NASH animal models support efficacy in NASH at doses relevant to humans.
 
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MDGL News: Statement of Changes in Beneficial Ownership (4) 09/19/2018 04:26:44 PM
MDGL News: Statement of Ownership (sc 13g) 08/10/2018 01:39:20 PM
MDGL News: Current Report Filing (8-k) 08/07/2018 08:52:35 AM
MDGL News: Madrigal Pharmaceuticals Reports 2018 Second Quarter Financial Results and Reviews Key Clinical Achievements 08/07/2018 06:50:00 AM
MDGL News: Quarterly Report (10-q) 08/07/2018 06:13:09 AM
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#117   Madrigal Pharmaceuticals Is Advancing Its NASH Pipeline in 2018 DMOST 10/19/18 04:24:02 PM
#116   Why Analysts See a Massive Upside in Madrigal Stock DMOST 10/03/18 03:43:13 PM
#115   5 Biotech Stocks to Play the Sector’s Next DMOST 09/27/18 08:31:12 AM
#114   Is Viking Therapeutics the Best NASH Stock to DMOST 09/20/18 09:12:42 PM
#113   Today's Research Reports on Trending Tickers: Madrigal Pharmaceuticals DMOST 09/19/18 12:13:40 PM
#112   Viking Therapeutics and Madrigal Pharmaceuticals Are Racing to DMOST 09/19/18 12:12:21 PM
#111   3 Top Stocks for Investing in Pharma's Next DMOST 09/12/18 10:36:51 PM
#110   MDGL buy 243.92 stocktrademan 08/21/18 01:23:47 PM
#109   Is Viking Therapeutics, Inc. a Buy? DMOST 08/20/18 01:37:54 AM
#108   Madrigal Pharmaceuticals Inc (MDGL) DMOST 08/13/18 11:49:59 PM
#107   Madrigal (MDGL) Posts Narrower than Expected Loss in Q2 DMOST 08/07/18 10:39:32 PM
#106   Madrigal: 2Q Earnings Snapshot DMOST 08/07/18 08:31:08 AM
#105   Madrigal Pharmaceuticals Reports 2018 Second Quarter Financial Results DMOST 08/07/18 07:40:37 AM
#104   Goldman Sachs Cuts Madrigal Pharma To Neutral Given DMOST 08/07/18 05:50:06 AM
#103   $305 was the set price of shares in DMOST 07/31/18 02:21:02 AM
#102   How a little 10-employee pharma company hit a DMOST 07/27/18 05:25:21 AM
#101   Breakfast Technical Briefing on Mirati Therapeutics and Three DMOST 07/17/18 08:58:43 AM
#100   3 Biotech Stocks With Big News Coming in NASH DMOST 07/16/18 05:47:23 AM
#99   Best ETFs for 2018: ALPS Medical Breakthroughs ETF DMOST 07/02/18 09:03:06 PM
#98   Madrigal Pharmaceuticals Inc ( MDGL )......Buyout of DMOST 06/20/18 08:13:23 AM
#97   investorshub.advfn.com/uimage/uploads/2018/6/20/djuqdMDGL.PNG DMOST 06/20/18 06:49:26 AM
#96   Thanks a million...... Millions242 06/18/18 12:57:21 PM
#95   MDGL .........A quicker and more convenient way to check DMOST 06/16/18 05:56:20 AM
#94   Cash for NASH: 2 Top Biotech Takeover Targets DMOST 06/15/18 03:13:43 PM
#93   Thanx man.... It really helps when I ask Imperial Whazoo 06/15/18 12:57:02 PM
#92   Here's the link for MDGL www.gurufocus.com Millions242 06/14/18 10:52:42 PM
#91   Lots of inside selling from executives. They Millions242 06/14/18 02:37:31 PM
#90   Major Pharmaceuticals Scare Off Short Sellers DMOST 06/14/18 05:44:12 AM
#89   Sure, It's what's systematically happens when these things occur....Nothing DMOST 06/13/18 10:51:21 PM
#88   A previous post has the link....(see below) DMOST 06/13/18 10:46:51 PM
#87   good call... [SMART MONEY] 06/13/18 07:55:54 PM
#86   Well, I looked through all my news links Imperial Whazoo 06/13/18 04:09:56 PM
#85   ....And of course the rumors of a buy DMOST 06/13/18 02:51:45 PM
#84   Madrigal Pharma Is Exploring Sale After Receiving Takeover Interest DMOST 06/13/18 02:35:34 PM
#83   Let me join in and say that I Imperial Whazoo 06/13/18 12:07:52 PM
#82   True. MDGL Has been for me also, as DMOST 06/08/18 02:28:23 PM
#80   I think a 10-15% drop is very possible tomorrow T695 06/07/18 05:15:27 PM
#79   This ticker is a traders dream... long and T695 06/07/18 05:14:20 PM
#78   MARKED !...........as just another short opinion, wishin DMOST 06/07/18 05:08:27 PM
#77   They going to kill this thing tomorrow... mark T695 06/07/18 03:49:04 PM
#76   MDGL ...little viking .........And DMOST 06/07/18 01:57:59 PM
#75   MDGL will tank when Wall st. finds out greens12 06/07/18 01:43:28 PM
#74  Restored MDGL sinking while viking is going up...Pair greens12 06/07/18 01:08:28 PM
#73   New daily low coming soon T695 06/07/18 12:55:00 PM
#72   MDGL , Is it really?...Don't keep your pole in DMOST 06/07/18 12:23:20 PM
#71  Restored My Pair trade is working. Short MDGL greens12 06/07/18 11:49:06 AM
#70   Or maybe $240 T695 06/07/18 11:42:15 AM
#69   $270 seem like a good spot to cover T695 06/07/18 10:40:37 AM
#68   Not quite that low , it now seems . DMOST 06/07/18 06:48:14 AM
#66   will drop to 150.00 range with upcoming greens12 06/07/18 12:40:08 AM
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