Covid 19 deaths reduced 44% by Colchicine

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[Ubertino]

Montreal Heart Institute Colcorona Study receives grant from the COVID-19 Therapeutics Accelerator via the Bill & Melinda Gates Foundation to investigate cheap, readily available drug
Clinical study evaluating colchicine as a potential treatment to reduce inflammatory conditions seen in patients with COVID-19

May 12, 2020 08:50 ET | Source: Montreal Heart Institute
multilang-release


MONTREAL, May 12, 2020 (GLOBE NEWSWIRE) -- The Montreal Heart Institute (MHI) Research Center today announced a 3-million-dollar grant from the COVID-19 Therapeutics Accelerator for its innovative ColCorona COVID-19 clinical trial. This contact-less at home study is investigating colchicine as a potential treatment to reduce severe inflammatory conditions associated with COVID-19, slow disease progression, and save patient lives.

As this low-cost common gout drug presents itself as a potential treatment to fight coronavirus, this recognition by the Foundation will enable MHI to bring this research to a greater number of people affected by COVID-19, especially in areas where the population is more vulnerable due to health and economic inequities.

The COVID-19 Therapeutics Accelerator is an initiative launched by the Bill & Melinda Gates Foundation, Wellcome, and Mastercard, with funding from an array of public and philanthropic donors, to speed up the response to the COVID-19 pandemic by funding the identification, assessment, development and scale up of treatments.

“ColCorona exemplifies how we can look to bring scientific breakthroughs in a time- and cost-effective manner to patients by repurposing older drugs,” said Dr. Jean-Claude Tardif, Director of the Research Center at MHI, Professor of Medicine at the University of Montreal, and ColCorona primary investigator. “We are at a critical juncture in searching for a treatment for patients with coronavirus and I, along with my colleagues involved in ColCorona around the world, are hopeful that colchicine will prove to have a positive effect on the serious inflammation seen in COVID-19, potentially keeping patients out of the ICU and ultimately saving lives.”

The hypothesis is that colchicine may prevent the phenomenon of major inflammatory storm responsible for severe complications seen in patients with COVID-19. This is one of the few current studies of COVID-19 infection in which non-hospitalized individuals can participate. The clinical study is contact-less and is done from home. MHI is currently assessing several sites and support associations in which assistance for patients wanting to join the study can be provided. Anyone interested in receiving more information or wanting their association to be considered can call 1 877 536 6837 to find out more.

The patient eligibility criteria for the study are:

Diagnosis of COVID-19
Be 40 years and over
Not hospitalized
Be willing to take the drug or placebo daily for 30 days
Be willing to participate in two follow-up calls by phone or videoconference.
Women of child bearing potential who do not take contraceptives, those who are pregnant, or those who are breastfeeding are not eligible for the trial. Physicians with patients, or people with a positive COVID-19 diagnosis who are interested in participating in the clinical study, can call the hotline any time at 1-877-536-6837.

For more information on COLCORONA clinical trial, visit www.colcorona.net.

COLCORONA is coordinated by the Montreal Health Innovations Coordinating Center (MHICC), funded by the Government of Quebec, and supported by Pharmascience, CGI and the U.S. National Institutes of Health (NIH).

COVID-19 Therapeutics Accelerator donors include the Bill & Melinda Gates Foundation, Wellcome, Mastercard, U.K. Department for International Development, Chan Zuckerberg Initiative, Michael & Susan Dell Foundation, Avast, Zhang Yiming, Alwaleed Philanthropies, EQT and Madonna.

About Colchicine
Colchicine is a generic, orally administered anti-inflammatory medication that is currently indicated for the management of pericarditis, gout, and familial Mediterranean fever. It is not a non-steroidal anti-inflammatory medicine. Colchicine was recently studied in the COLCOT study (published in the New England Journal of Medicine), which compared colchicine 0.5mg daily to placebo on top of standard of care in preventing ischemic cardiovascular events in patients with a recent myocardial infarction (MI).

About ColCorona
COLCORONA is a randomized, double-blind, placebo-controlled study. It was initiated by Dr. Jean-Claude Tardif, Director of the MHI Research Center and Professor of Medicine at the University of Montreal and aims to determine if colchicine may prevent the phenomenon of major inflammatory storm observed in adults suffering from serious complications linked to COVID-19. The clinical trial requires the recruitment of 6,000 patients who meet all the inclusion criteria and none of the exclusion criteria. Patients will be randomly assigned to either colchicine or a placebo (1:1 ratio) for 30 days. Evaluations by phone or videoconference will then take place 15 and 30 days after the randomization. The sample size will allow researchers to detect if there is a reduction of at least 25% in the risk of events, taking into account a 7% event rate in the placebo group. The study will be monitored by a data monitoring committee (DMC) that includes experienced clinical researchers.

About the Montreal Heart Institute
Founded in 1954, the Montreal Heart Institute constantly aims for the highest standards of excellence in the cardiovascular field through its leadership in clinical and basic research, ultra-specialized care, professional training, and prevention. It houses the largest research center in Canada, the largest cardiovascular prevention center and the largest cardiovascular genetics center in the country. The Institute is affiliated with the University of Montreal and has more than 2,000 employees, including 245 doctors and more than 85 researchers.

About the Montreal Health Innovations Coordinating Center (MHICC):
The Montreal Health Innovations Coordinating Center (MHICC) is a leading academic clinical research organization and an integral part of the Montreal Heart Institute (MHI). The MHICC possesses an established network of collaborators in over 4,500 clinical sites in more than 30 countries. It has specific expertise in precision medicine, low-cost high-quality clinical trials, and drug repurposing.

About Pharmascience
Founded in 1983, Pharmascience Inc. is the largest pharmaceutical employer in Quebec. With its head office located in Montreal and its 1,500 employees, Pharmascience Inc. is a private, full-service pharmaceutical company with deep roots in Canada, and whose global reach is growing, in part thanks to the distribution of its products in more than 60 countries. Ranked 56th among the top 100 Canadian investors in research and development (R&D) thanks to $ 43 million investment in 2018, Pharmascience Inc. is the 4th largest manufacturer of over-the-counter generic drugs in the country. www.pharmascience.com

About CGI
Founded in 1976, CGI is one of the world's largest information technology (IT) and management consulting firms. From hundreds of locations around the world, CGI offers a complete portfolio of services and solutions: strategic IT and management consulting services, systems integration services, intellectual property solutions as well as IT and business process management services in delegated mode. www.cgi.com/canada

Note to media: ColCorona Clinical Trial is available in Montreal, New York Tri State Area (NYU Langone), New Jersey and Connecticut, California (UCSF), Madrid (Spain), British Columbia, Ontario and Alberta. Lead investigators in each city are available for interviews.

Source: Montreal Heart Institute

Media inquiries:

For Montreal Heart Institute:
Camille Turbide
[e-mail]
[phone]

https://www.globenewswire.com/news-release/2020/05/12/2031943/0/en/Montreal-Heart-Institute-Colcorona-Study-receives-grant-from-the-COVID-19-Therapeutics-Accelerator-via-the-Bill-Melinda-Gates-Foundation-to-investigate-cheap-readily-available-drug.html

[Ubertino]

Quebec researchers say they have found an effective drug to fight COVID-19

The Canadian Press Staff
Published Saturday, January 23, 2021 7:51AM EST
https://montreal.ctvnews.ca/quebec-researchers-say-they-have-found-an-effective-drug-to-fight-covid-19-1.5279310

MONTREAL -- A team of researchers from the Montreal Heart Institute believes they have found an effective weapon against COVID-19: colchicine, an oral tablet already known and used for other diseases.

For Dr. Jean-Claude Tardif, who led the study, this is a "major scientific discovery" and colchicine is the first "effective oral drug to treat out-of-hospital patients."

"To be able to offer this, from Quebec, and for the planet, we are very happy," said Tardif.

The ColCorona study involved 4,159 patients whose diagnosis of COVID-19 had been proven by a nasopharyngeal test (PCR).

Complete coverage at CTVNews.ca/coronavirus
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Analysis of the study found that colchicine resulted in reductions in hospitalizations by 25 per cent, the need for mechanical ventilation by 50 per cent, and deaths by 44 per cent.

"This is the first hope for patients who have COVID, who are worried and who hope that they will not have complications, there were no tablets that could be taken by mouth and reduce the risks," said Tardif.

Doctor Tardif believes that prescribing the drug could help reduce congestion in hospitals quickly and reduce health-care costs here as elsewhere.

"Our study showed the effectiveness of treatment using colchicine to prevent the phenomenon of the major inflammatory storm and reduce complications related to COVID-19," said Tardif.

Colchicine could be used very quickly to treat people with COVID-19, the researcher says.

"Colchicine is old as it is, we've been treating gout with it for hundreds of years, so it's available in pharmacies, so any doctor tomorrow who reads this can definitely decide to prescribe if he wants."

On Friday evening, Premier Francois Legault called the study "big news" on social networks.

In the spring, Legault said the Colcorona study was one of the largest studies in the world to fight the virus.

The randomized, double-blind, placebo-controlled study was deployed in Canada, the United States, Europe, South America and South Africa.

"It was a double-blind study, meaning neither the patient, nor the team that ran the study including me, knew whether the patient was taking the placebo or the drug, there was just a group, independent from us, which was aware," explained Tardif.

"We are very proud of the work accomplished, it is a clinically convincing result," he said adding that he assembled a spectacular team from all over Quebec including microbiologists, intensivists, statisticians, computer scientists and epidemiologists,

The Centre de Coordination des Essais Cliniques de Montréal (MHICC) of the Montreal Heart Institute coordinated the study.

-- this report by The Canadian Press was first published Jan. 23, 2021.

https://montreal.ctvnews.ca/quebec-researchers-say-they-have-found-an-effective-drug-to-fight-covid-19-1.5279310