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Last Post: 9/18/2018 10:36:33 AM - Followers: 20 - Board type: Free - Posts Today: 0

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Over the last three decades, intraoral dosage forms have been evolving as an acceptable and in some cases as the preferred, alternative to conventional tablets and capsules. Among them, Oral sprays are the fastest, most effective and comfortable way to take medicines, nutrients, minerals and vitamins. They have been acquiring important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life.

Oral sprays have the unique property of rapidly releasing the drug in the oral cavity, thus obviating the requirement of water during administration. Therefore, these dosage forms have lured the market for a certain section of the patient population which includes dysphagic, bed ridden, and psychic, geriatric patients. This article focuses on the transmucosal view , spray formulation aspects , advances made so far in the field oral sprays and patented technologies.






 








 

Abstract: Nitroglycerin (glyceryl trinitrate, CAS 55-63-0, NTG) administered with an oral spray may be more effective in relieving anginal pain than sublingual tablets especially when the patient’s mouth is dry. In this study, the effect of a NTG oral spray (Myocor Spray) on exercise-induced angina was compared with that of a sublingual tablet in relation to the oral dryness. In 17 patients with effort angina, graded bicycle exercise was performed twice at an interval of one week.

Exercise was discontinued upon the onset of moderate anginal pain. Immediately after exercise, the oral dryness was evaluated by touching the tip of the tongue with a blotting paper for a moment. Then, 0.3 mg of NTG was administered by either a squirt of spray or a sublingual tablet in a randomized crossover fashion. Exercise results were reproducible between two exercise tests. According to the extent of the wet area of the blotting paper, the subjects were divided into two groups.

In 7 patients of the wet group, the remission times of chest pain and ST segment depression were not significantly different by the formulation of NTG. In 10 patients of the dry group, however, both chest pain and ST depression more rapidly recovered with use of the oral spray (p < 0.05 and p < 0.05, respectively). These results strongly suggest that the NTG oral spray is superior to the sublingual tablet in relieving anginal attacks, when the oral wetness is decreased.







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#112   Sure did, looks like a lot of potential here Luckynumber7 09/18/18 10:36:33 AM
#111   Did I see 36M shares outstanding? JohnCM 09/18/18 10:35:12 AM
#110   $ICNAF Prepare For A Boom In Pot Stocks lithiumjr 09/16/18 02:42:49 PM
#109   How we doing here GELDTEAM 09/13/18 01:44:43 PM
#108   Take a look at the afternoon run! apollo44 09/12/18 03:55:45 PM
#107   Marijuana Stocks Connecting The Dots: New Opportunity Ahead lithiumjr 09/12/18 08:30:14 AM
#106   I thought they were gunning for a nasal grubby 09/10/18 02:46:16 PM
#105   3 catalysts identified in NR lithiumjr 09/06/18 09:06:26 AM
#104   Integrated Cannabis Company, Inc. Provides Corporate Update lithiumjr 09/06/18 08:56:30 AM
#103   Canadian marijuana stocks are a great sector to Jacob76 09/01/18 05:04:41 PM
#102   CRPGF symbol changed to ICNAF TenKay 07/27/18 09:35:26 AM
#101   Transaction was approved by the CSE and the makingmoneynow 06/09/18 03:07:14 AM
#100   Can someone help me understand the current status NutsNBoltz 06/08/18 09:57:36 AM
#99   Any idea when they will be allowed to grubby 02/14/18 02:18:12 PM
#98   X-Sprays are the ONLY delivery method that I tocotuga 01/28/18 10:54:19 AM
#97   Volume picking up in US. Look forward grubby 01/17/18 05:51:06 PM
#96   Need to get that PR Company pumping this grubby 12/13/17 09:57:27 AM
#95   Back in again at .666. Should see I Need Money 12/11/17 03:59:52 PM
#94   CRPGF show me a little Red/Green into close! TradeUptrendz 12/01/17 02:52:50 PM
#93   I’ll sell my shares in January Tdogwm 11/30/17 03:59:22 PM
#92   Yeah, solid price movement too. Goes to show TheOtcStockGuy 11/30/17 03:34:32 PM
#91   Nice increase in volume today LivH 11/30/17 01:48:06 PM
#90   Looking good here, $2 test in coming days TradeUptrendz 11/30/17 12:22:15 PM
#89   Getting some at open Tdogwm 11/30/17 09:20:27 AM
#88   CRPGF news out this morning http://marijuanastocks.com/cnrp-mining-crpgf- TheOtcStockGuy 11/30/17 08:49:45 AM
#87   We shall see, dont think the retrace is I Need Money 11/22/17 01:03:19 AM
#86   Yeah idk about that man. I mean I TheOtcStockGuy 11/21/17 10:08:55 AM
#85   I think we see 60s and 70s again... I Need Money 11/10/17 12:49:40 PM
#84   I’m not touching this thing unless it GE dawood 11/10/17 12:40:12 PM
#83   Agree. Time to look for reentry on pullback... I Need Money 11/10/17 09:57:14 AM
#82   I had to get out. Pump seemed done. dawood 11/10/17 09:54:39 AM
#81   From sleep to energy, X-Sprays proprietary CBD infused Decimus1 11/10/17 04:08:03 AM
#80   I got that notification and loaded at .61... I Need Money 11/10/17 03:00:49 AM
#79   http://marijuanastocks.com/connect-the-dots-cnrp-mining-inc-crpgf/ Decimus1 11/09/17 11:32:23 PM
#78   Fun fun Now i keep getn txt messages TaperT2 11/09/17 08:33:51 PM
#77   Looks like some coward just had to sell Decimus1 11/09/17 04:06:42 PM
#76   Closing green again. Going to close very strong. Decimus1 11/09/17 03:17:41 PM
#75   Head back down Lion33 11/09/17 03:15:11 PM
#74   No pullbacks. Only minor dips due to some profit Decimus1 11/09/17 02:41:05 PM
#73   Pullback into the weekend. Reload tomorrow afternoon.... I Need Money 11/09/17 01:52:53 PM
#72   It is running back up. I can see it Decimus1 11/09/17 01:29:36 PM
#71   Little bit of profit taking is all it Decimus1 11/09/17 12:46:36 PM
#70   Just a minor dip. Take advantage of it. It Decimus1 11/09/17 11:02:33 AM
#69   Soon to be under $1 Lion33 11/09/17 10:54:15 AM
#68   Damn. She’s crashing dawood 11/09/17 10:44:41 AM
#67   CRPGF has been a monster the last two TheOtcStockGuy 11/09/17 09:41:35 AM
#66   stock is a beast. Decimus1 11/08/17 07:51:23 PM
#65   Damn. Kind a quiet in here. This thing dawood 11/08/17 07:35:17 PM
#64   I saw the latest news. Future is huge here. Decimus1 11/08/17 03:50:50 PM
#63   I wonder who are clowns selling when it Decimus1 11/08/17 01:36:06 PM
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