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Aurinia Pharmaceuticals Inc (AUPH)

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Last Post: 3/27/2020 1:17:40 PM - Followers: 185 - Board type: Free - Posts Today: 0

Aurinia is a late-stage biopharmaceutical company providing novel products specifically engineered to treat a limited, targeted patient population suffering from serious disease states for which there is a high unmet medical need.

*Aurinia Pharmaceuticals Inc.
http://www.auriniapharma.com/
 

Pipeline

 

Pipeline

Pipeline

Candidate & Indication Development Stage
Preclinical Phase 1 Phase 2 Phase 3 Market
VOCLOSPORINLupus Nephritis (LN)
Preclinical Phase complete
Phase 1 Phase complete
Phase 2 Phase in progress
Phase 3 Phase not started
Market Phase not started

Aurinia is committed to working in areas of high unmet medical need and is poised to deliver the first approved therapy in the U.S. and Europe for the treatment of lupus nephritis, or LN.

The Voclosporin Advantage

Voclosporin, an investigational drug, is a novel and potentially best-in-class calcineurin inhibitor (“CNI”) with clinical data in over 2,000 patients across indications. Voclosporin is an immunosuppressant, with a synergistic and dual mechanism of action that has the potential to improve near- and long-term outcomes in lupus nephritis (LN) when added to standard of care mycophenolate mofetil (MMF). It has been granted “fast track status” by the U.S. Food & Drug Administration (FDA).

Voclosporin Could Transform the LN treatment Landscape

Voclosporin has the potential to become a best in class medication and the first approved treatment for LN in the U.S. and Europe, effectively altering the current treatment paradigm for the disease.

Advantages of Voclosporin Combined with Standard of Care (SoC)

Our clinical data suggests that adding voclosporin to the current SoC of MMF for the treatment of lupus nephritis (LN) will yield superior results to using the standard of care alone.

Additionally, voclosporin may prove to be an ideal therapy for lupus nephritis due to advantages such as:

  • Improved efficacy
    Increased safety
    Oral administration
    Improved average time to renal response or remission
    Improved duration of renal response
    Reduction in steroid burden
    Potential first line add-on to MMF
    Fewer toxic immunosuppressants required
Benefits of Voclosporin

Potential Benefits of Voclosporin

In clinical trials, Voclosporin has been shown to be especially effective in the presence of low dose steroids with rapid reduction of LN inflammatory markers and overall improved renal stability.

The list of potential product benefits includes:

LN Critical Need Voclosporin (based on AURA Results)
Control of Active Disease
Rapid Disease Control
Lower Steroid Burden
Impact on Extra-renal disease
Convenient Treatment Regimen

In previous studies, over 2000 patients have been treated with Voclosporin with no abnormal or unexpected SAE’s

Well Characterized Safety Profile

Efficacy of calcineurin inhibition has already been established. Voclosporin has a well-characterized safety profile (over 2,000 patient exposures across multiple years) across indications.

No new safety signals were observed with the use of Voclosporin in LN patients; Voclosporin was well-tolerated and renal function remained stable in clinical studies. The overall safety profile is consistent with other immunosuppressive drugs.

 

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#9929  Sticky Note This is from Auph IR, shared with me Lunacy_John Galt 12/09/19 04:11:51 PM
#10572   Links provided by sifisailor. Hotrodder1 03/27/20 01:17:40 PM
#10571   PS, I couldn’t access yesterday’s live presentation. Hotrodder1 03/27/20 01:15:26 PM
#10570   I watched some of the presantion a little Hotrodder1 03/27/20 01:14:02 PM
#10569   does anyone have cliff notes from yesterdays webinars? cervelo 03/27/20 12:08:40 PM
#10568   It does bode well for tomorrow. ScifiSailor 03/26/20 07:50:57 PM
#10567   look at after hours trading, over a half thesaud 03/26/20 06:49:00 PM
#10566   would be nice to know if insiders are cervelo 03/26/20 03:14:35 PM
#10565   Links to today's webinars: ScifiSailor 03/26/20 10:40:53 AM
#10564   Hope we get some new info this afternoon. nferna 03/26/20 10:25:20 AM
#10563   Thanks Luna, much appreciated . Maciste 03/25/20 09:51:35 PM
#10562   Will anyone on this board be there tomorrow? If Hotrodder1 03/25/20 08:21:34 PM
#10561   they are presenting p3 results tomorrow at the thesaud 03/25/20 02:59:16 PM
#10560   Is there any chance Aurinia is testing Voclosporin Hotrodder1 03/25/20 12:27:06 PM
#10559   When we were told about TARP in 2008, Zeppo 03/25/20 11:37:30 AM
#10558   Does anyone else think that the 2 trillion Churchill54 03/25/20 09:16:23 AM
#10557   You're certainly in my thoughts, and you got Lunacy_John Galt 03/24/20 10:56:37 PM
#10556   It's nice to hear all of your prayers Rockydoxie 03/24/20 05:10:56 PM
#10555   Thank you all for your support and prayers, Maciste 03/24/20 04:17:29 PM
#10554   Done. God bless you. nsomniyak 03/24/20 02:12:13 PM
#10553   Maciste, consider it done by me. rumrunner528 03/24/20 12:12:42 PM
#10552   thank you all. i finally got off dialysis. cervelo 03/24/20 11:16:46 AM
#10551   Hey Maciste. I’m adding you to my Hotrodder1 03/24/20 07:13:49 AM
#10550   stay positive maciste, I know how you feel, thesaud 03/23/20 09:42:13 PM
#10549   Maciste, I’m so truly sorry to hear that. Jesspro 03/23/20 09:41:38 PM
#10548   Sorry to hear that praying for you. Maciste 03/23/20 09:07:02 PM
#10547   Hoping for a quick recovery my friend! Lunacy_John Galt 03/23/20 08:27:03 PM
#10546   Praying for you, cervelo. rumrunner528 03/23/20 01:06:00 PM
#10545   Cerv, sorry to hear that. I hope you’re Jesspro 03/23/20 12:28:25 PM
#10544   your very lucky you did not get sepsis! thesaud 03/23/20 12:11:41 PM
#10543   Praying for you cervelo!!! Hotrodder1 03/23/20 11:03:14 AM
#10542   flu, spetic shock, all organs quit. life support cervelo 03/23/20 10:46:09 AM
#10541   hi jess, did you know PSTI is working thesaud 03/21/20 03:18:06 PM
#10540   Don’t know if Voclosporin could play a part Jesspro 03/21/20 12:24:54 PM
#10539   Cervelo, May I ask why u r in Jesspro 03/20/20 10:22:04 PM
#10538   been laying in a hospital bed the last cervelo 03/20/20 05:08:11 PM
#10537   Most of know what we have! Great returns Hotrodder1 03/18/20 07:45:27 PM
#10536   Well this answers my last post LivingTheDream 03/18/20 12:16:02 PM
#10535   https://www.statnews.com/pharmalot/2020/03/18/coronavirus-covid19-clinical-trial LivingTheDream 03/18/20 12:08:58 PM
#10534   https://finance.yahoo.com/news/aurinia-announces-aurora-phase-3-100500559.html thesaud 03/18/20 07:46:43 AM
#10533   https://www.marketwatch.com/press-release/aurinia-pharmaceuticals-establishes-us thesaud 03/17/20 07:09:51 AM
#10532   we are getting pasted in the premarket, wonder thesaud 03/16/20 08:06:15 AM
#10531   Filing of rolling submission.. no help in this biotech_researcher 03/16/20 07:05:39 AM
#10530   https://finance.yahoo.com/news/aurinia-pharmaceuticals-initiates-rolling-submiss thesaud 03/16/20 06:47:16 AM
#10529   Aurinia Pharmaceuticals Inc. Aurinia Pharmaceuticals Inc. has just released Hotrodder1 03/16/20 06:30:37 AM
#10528   Postpone any taxes as long as possible!!!! Hotrodder1 03/14/20 12:11:22 PM
#10527   Thanks for making me think this through a Pepperchino 03/14/20 12:01:12 PM
#10526   wondering why no pop in price today? thesaud 03/13/20 10:48:57 AM
#10525   Pep - how does that make sense? Merc1 03/13/20 10:32:40 AM
#10524   Nice! Pepperchino 03/13/20 06:50:43 AM
#10523   I understand Pepper! I’m in with 50k at avg Hotrodder1 03/12/20 06:40:13 PM
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