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Aurinia Pharmaceuticals Inc (AUPH)

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Last Post: 10/16/2019 5:13:31 PM - Followers: 160 - Board type: Free - Posts Today: 10

Aurinia is a late-stage biopharmaceutical company providing novel products specifically engineered to treat a limited, targeted patient population suffering from serious disease states for which there is a high unmet medical need.

*Aurinia Pharmaceuticals Inc.
http://www.auriniapharma.com/
 

Pipeline

 

Pipeline

Pipeline

Candidate & Indication Development Stage
Preclinical Phase 1 Phase 2 Phase 3 Market
VOCLOSPORINLupus Nephritis (LN)
Preclinical Phase complete
Phase 1 Phase complete
Phase 2 Phase in progress
Phase 3 Phase not started
Market Phase not started

Aurinia is committed to working in areas of high unmet medical need and is poised to deliver the first approved therapy in the U.S. and Europe for the treatment of lupus nephritis, or LN.

The Voclosporin Advantage

Voclosporin, an investigational drug, is a novel and potentially best-in-class calcineurin inhibitor (“CNI”) with clinical data in over 2,000 patients across indications. Voclosporin is an immunosuppressant, with a synergistic and dual mechanism of action that has the potential to improve near- and long-term outcomes in lupus nephritis (LN) when added to standard of care mycophenolate mofetil (MMF). It has been granted “fast track status” by the U.S. Food & Drug Administration (FDA).

Voclosporin Could Transform the LN treatment Landscape

Voclosporin has the potential to become a best in class medication and the first approved treatment for LN in the U.S. and Europe, effectively altering the current treatment paradigm for the disease.

Advantages of Voclosporin Combined with Standard of Care (SoC)

Our clinical data suggests that adding voclosporin to the current SoC of MMF for the treatment of lupus nephritis (LN) will yield superior results to using the standard of care alone.

Additionally, voclosporin may prove to be an ideal therapy for lupus nephritis due to advantages such as:

  • Improved efficacy
    Increased safety
    Oral administration
    Improved average time to renal response or remission
    Improved duration of renal response
    Reduction in steroid burden
    Potential first line add-on to MMF
    Fewer toxic immunosuppressants required
Benefits of Voclosporin

Potential Benefits of Voclosporin

In clinical trials, Voclosporin has been shown to be especially effective in the presence of low dose steroids with rapid reduction of LN inflammatory markers and overall improved renal stability.

The list of potential product benefits includes:

LN Critical Need Voclosporin (based on AURA Results)
Control of Active Disease
Rapid Disease Control
Lower Steroid Burden
Impact on Extra-renal disease
Convenient Treatment Regimen

In previous studies, over 2000 patients have been treated with Voclosporin with no abnormal or unexpected SAE’s

Well Characterized Safety Profile

Efficacy of calcineurin inhibition has already been established. Voclosporin has a well-characterized safety profile (over 2,000 patient exposures across multiple years) across indications.

No new safety signals were observed with the use of Voclosporin in LN patients; Voclosporin was well-tolerated and renal function remained stable in clinical studies. The overall safety profile is consistent with other immunosuppressive drugs.

 

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News News Alert: Report of Foreign Issuer (6-k) 10/16/2019 06:31:12 AM
PostSubject
#8546  Sticky Note https://www.bloomburton.com/research/AUPH20190613.pdf Lunacy_John Galt 06/13/19 03:40:21 PM
#9164   I wonder if we will have a down Jesspro 10/16/19 05:13:31 PM
#9163   I hope come the end of the year cervelo 10/16/19 04:26:14 PM
#9162   Hello almost everyone. Nice day yesterday and Maciste 10/16/19 04:12:18 PM
#9161   I would share your concern if this had nsomniyak 10/16/19 11:28:06 AM
#9160   The fact that Aurora II is in existence Zeppo 10/16/19 11:12:30 AM
#9159   Luna, it seems that way but there is Jesspro 10/16/19 10:58:40 AM
#9158   Based off the 2 statements below from Aurinia, Lunacy_John Galt 10/16/19 10:21:53 AM
#9157   https://finance.yahoo.com/news/aurinia-reports-last-patient-study-103000637.html thesaud 10/16/19 07:59:24 AM
#9156   It's ok. They know best how much nferna 10/16/19 07:40:07 AM
#9155   Scooped up some but not at the low. biotech_researcher 10/16/19 07:13:24 AM
#9154   Theoretically, there is nothing that would prevent insiders nsomniyak 10/15/19 09:39:00 PM
#9153   Greenleaf picked up 8k shares today? Anyone else Awlau 10/15/19 08:37:22 PM
#9152   ATM intention somerssalt 10/15/19 05:43:28 PM
#9151   Hi Jess. Another ARIA alumni here. farmecologist 10/15/19 05:21:15 PM
#9150   I missed the low yesterday and when we ScifiSailor 10/15/19 05:07:15 PM
#9149   I wonder who initiated the leak in this Jesspro 10/15/19 04:32:23 PM
#9148   * * $AUPH Video Chart 10-15-2019 * * ClayTrader 10/15/19 04:23:46 PM
#9147   well its still down to 4.6 right? Newbie1421 10/15/19 04:04:11 PM
#9146   This huge volume on the up side is biotech_researcher 10/15/19 02:00:50 PM
#9145   I fear not the $10 soon. Jesspro 10/15/19 01:39:50 PM
#9144   Anytime I get this odd of 99.999% of Jesspro 10/15/19 01:37:12 PM
#9143   Jess. Looks like we might have been on Mkc12five 10/15/19 01:16:54 PM
#9142   Just curious.....do you think BR there was a kipster210 10/15/19 01:12:18 PM
#9141   OR its just all of us chumps buying Newbie1421 10/15/19 11:21:25 AM
#9140   Looks like someone just bought 940,000 shares. heldnova 10/15/19 11:17:22 AM
#9138   Thats how the game is played. atalia 10/15/19 11:02:19 AM
#9137   Jess, indeed! biotech_researcher 10/15/19 10:58:03 AM
#9136   Atalia, the people who perpetrated it are also Jesspro 10/15/19 10:47:06 AM
#9135   last week a lot of people were played atalia 10/15/19 10:27:06 AM
#9134   There seems to be a lot of noise zzaatt 10/15/19 09:50:50 AM
#9133   We finally got a bid..... biotech_researcher 10/15/19 09:42:06 AM
#9132   I would expect a move higher today.. Bounce. biotech_researcher 10/15/19 06:15:55 AM
#9131   Now at the low of the day, down biotech_researcher 10/14/19 12:43:17 PM
#9130   Mkc, if it’s a failure, there are two Jesspro 10/14/19 12:33:41 PM
#9128   If it is a failure then "They" are Mkc12five 10/14/19 11:39:32 AM
#9126   It seems like they (whoever is bringing the Jesspro 10/14/19 10:21:31 AM
#9125   GULP! biotech_researcher 10/14/19 10:10:13 AM
#9123   Thanks for your well reasoned insight. ScifiSailor 10/12/19 08:49:48 AM
#9122   Voclosporin’s phase 2 test results chance of being Jesspro 10/12/19 07:09:27 AM
#9121   I haven't been around much lately, and I Lunacy_John Galt 10/11/19 08:12:47 PM
#9120   * * $AUPH Video Chart 10-11-2019 * * ClayTrader 10/11/19 04:54:30 PM
#9119   Trying so hard...LOL Jesspro 10/11/19 04:42:50 PM
#9118   That ATM was not that large to cause biotech_researcher 10/11/19 03:56:12 PM
#9117   Biotechs in general didn't have a shorted windfall Zeppo 10/11/19 03:54:38 PM
#9116   This is not good.. Biotechs in general are rallying.. biotech_researcher 10/11/19 02:49:34 PM
#9115   Sure would be nice to see history repeat Lunacy_John Galt 10/11/19 02:09:49 PM
#9114   From Pawcio Twitter: lidopete 10/11/19 10:57:53 AM
#9113   Luna, we endured that at ARIAD day in Jesspro 10/11/19 10:23:15 AM
#9112   Just when you think it is safe to biotech_researcher 10/11/19 10:21:20 AM
#9109   It’s like 4000 shares premarket. Not worried about Awlau 10/11/19 09:29:17 AM
PostSubject