Holy Cow! RRdog, if your high estimate of 16.25 months is correct I think the FDA will be begging Peregrine
to file for accelerated approval. I will be happy to be utterly wrong about MOS! In my estimates I assume a
uniform rate of accrual over the 17 months since I have nothing else to base it on. Perhaps your estimates
are more like reality in that respect. What number would you get if you used a uniform rate? I am just using a
back-of-the-envelope estimate, nothing fancy at all.