Fidelity SPDR Advertisement
Home > Boards > Free Zone > User's Groups > Medical World News

Aspirin: New Evidence Is Helping Explain Additional Health

Public Reply | Private Reply | Keep | Last ReadPost New MsgNext 10 | Previous | Next
Preciouslife1 Member Profile
 
Followed By 68
Posts 15,170
Boards Moderated 3
Alias Born 11/05/05
160x600 placeholder
U.S. Stocks Edge Higher On Low Pre-holiday Volume
U.S. stocks inched higher on Monday, sending the benchmark S&P 500 index into record territory, as the decision by China's central bank to ease monetary policy last week continued to buoy global equity markets.
Top Equities Stories Of The Day
Redbox Owner Outerwall Among Tech Gainers
Intel Projects More Growth in 2015 -- Update
Faith-Based Shareholders Prepare Day of Reckoning for Bank of America
Appeals Court Grants TV Programmers Stay in FCC Dispute -- Update
Wireless Carriers Bid Up US Airwaves To Record
Messaging App Yik Yak Draws $300 Million-$400 Million Valuation - Sources
Technip Bids for CGG -- 2nd Update
GameStop's Earnings, Holiday-Quarter Forecast Disappoint
Preciouslife1   Saturday, 04/21/12 03:13:31 PM
Re: None
Post # of 4078 
Aspirin: New Evidence Is Helping Explain Additional Health Benefits and Open Potential for New Uses

http://www.sciencedaily.com/releases/2012/04/120419142932.htm

— New evidence is helping explain additional health benefits of aspirin. Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player in regulating cell growth and metabolism. AMPK which is considered a cellular fuel-gauge is switched on by exercise and the commonly used anti-diabetic medication metformin.
The research from scientists at McMaster University, the University of Dundee and the University of Melbourne will be published in the April 20 issue of the journal Science.

"We're finding this old dog of aspirin already knows new tricks," said Dr. Greg Steinberg, a co-principal investigator of the study. "In the current paper we show that, in contrast to exercise or metformin which increase AMPK activity by altering the cells energy balance, the effects of salicylate is totally reliant on a single Ser108 amino acid of the beta 1 subunit.

"We show that salicylate increases fat burning and reduces liver fat in obese mice and that this does not occur in genetically modified mice lacking the beta1 subunit of AMPK," he said. Steinberg is an associate professor of medicine in the Michael G. DeGroote School of Medicine at McMaster University and the Canada Research Chair in Metabolism and Obesity.These findings are important as a large clinical trial is currently underway testing whether salsalate (a well-tolerated aspirin derivative), can prevent Type 2 diabetes.

Salicylate, which is derived from willow bark, and is the active ingredient in aspirin, is believed to be one of the oldest drugs in the world with first reports of its use dating back to an Egyptian papyrus in 1543 BC.
An anti-inflammatory drug first used as a painkiller more than a century ago, aspirin is now given to people at risk of heart attacks and strokes as well as patients with vascular disease. McMaster scientists played a key role in that previous research.

Three studies published last month in the medical journal The Lancet reported that taking an aspirin every day may significantly reduce the risk of many cancers and prevent tumors from spreading. The unanswered question was how this anti-cancer benefit occurs.
With many recent studies showing that metformin may be important for cancer prevention the authors' study raise the interesting possibility that aspirin may also be working in a similar manner; however, further studies are needed as the concentrations of salicylate used in the current study were higher than the cancer trials. Nonetheless, the researchers' results show the one thing that salicylates and metformin hold in common is their ability to activate AMPK.


Bull-markets are born on pessimism, grow on skepticism, mature on optimism and die on euphoria .. Sir John Templeton
Make your Life a Mission .... NOT an Intermission. † §|PL1|§
Public Reply | Private Reply | Keep | Last ReadPost New MsgNext 10 | Previous | Next
Follow Board Follow Board Keyboard Shortcuts Report TOS Violation
X
Current Price
Change
Volume
Detailed Quote - Discussion Board
Intraday Chart
+/- to Watchlist