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Posted by: mjfdl Member Level  Date: Monday, April 12, 2004 7:54:04 PM
In reply to: None Post # of 11086  Send a link via email Share on Facebook Tweet this post
Entremed's Past...Why all the excitement?

[Note the dates on these posts, still available at the ENMD Yahoo board.This was nearly six years ago!...yet FDA rules still prevent experimenting with the combination in humans.This post will be included in the subject header as a series of posts on Entremed's past...to better understand where we are going in the future.]*Post to subject header

Oncology Lesson # 1 Why all the excitem
by: hemoncdoc 06/23/98 05:51 pm
Msg: 2471 of 51625

"Been their, done that!" Are you so sure? Among the 2400+ msgs. no one has explained to the adv. invester why the NCI, oncologists, etc. are so excited about AS/ES. When a new drug or treatment is first tested in animals it is tested in mice inoculated with one of appox. 50+ standard tumor cell lines the NCI maintains for drug testing. These cell lines are used because they have been shown to be very predictable in regards to rate of tumor grow, tine to death of animal from inoculation etc. If a mouse is injected with a fixed tumor load you can usually predict to the day when the mouse will die. Inoculated mice are then treated with the test drug looking for any prolongation of life, shrinkage of tumor, and if applicable whether any animals are 'cured'. This method of testing is used to identify any drugs that can be given in physiologic doses and show a response without killing or severely injuring the animal. Very few drugs pass this test. Many compounds show activity in cell cultures [ cyanide would be a good example] but are too toxic in test animals. Some drugs, in some tumor types, if given early, [ say within 5 days of inoculation ] may actually cure the animal. Our most active chemotherapy drugs, radation therapy, monoclonal antibodies ect. tend to perform poorly if the tumor has grown to any significiant size. No known drug or treatment is effective in all tumor types, at any size or stage.
AS/ES has shown 100% effectiveness in all of the 50+ NCI tumor types tested to date! THIS HAS NEVER BEEN SEEN BEFORE !!! No other known drug or treatment has ever shown this degree of activity. This 100% activity has been seen in large bulky tumors well beyond the point of 'cure' with any other known agent or treatment. THIS HAS NEVER BEEN SEEN BEFORE !!!
These results have been obtained without any appricable toxicity. No myelosupression, weight loss, nephrotoxicity, neurotoxicity, hair loss, ect. ect. THIS HAS NEVER BEEN SEEN BEFORE !!!
There are many new and inovative approaches to the treatment of cancer in pre-clinical and clinical trials. No treatment or apporach has yeilded these results. NONE !!! These results are unprecendeted.
Repeated treatment cycles has resulted in no resistance developing to AS/ES. THIS HAS NEVER BEEN SEEN BEFORE!!!
http://finance.messages.yahoo.com/bbs?.mm=FN&action=m&board=7076815&tid=enmd&sid=707...

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