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Re: pearsby09 post# 18947

Friday, 12/15/2017 7:28:53 PM

Friday, December 15, 2017 7:28:53 PM

Post# of 232046
Pears, we were not an experienced company. That is why Tony was asked to step in with his high level experience at Gilead. Nader was making statements about timelines he couldn’t back up because he was in uncharted waters. The trial itself was/is in uncharted waters for both Pro-140 and the FDA. Both sides learned and made adjustments as the glitches in the protocol were revealed as the trial progressed - hence 300 to 150 to 30 and back to 50 patients. BP would have completed this Trial six months ago because of resources and experience. Gilead is playing their poker hand saying you got nothing - come back later and maybe we will throw you a bone - hoping Pro-140 drys up and goes away. Tony C is the reason why I’m in - he knows Milligan’s agenda and style and that he will not moved unless forced. Tony’s job is to derisk Pro-140 through the clinical process and proceed with the BLA checklist to create shareholder value and apply the heat to attract the first suitor.

On another front the protocol for the Combo Trial has nothing to do with the patient population Pro-140 will have access to. Seriously Pears you know better if you have all the experience you say you have in this space. Pro-140 is going to have its day with an established company that will utilize it as it should be - a much better alternative than the current cocktail.

The big picture is first get through the Combo Trial because the FDA says you want a shot at Mono first things first. So here we are on the cusp of clearing that hurdle to get to the meat which is a successful Mono Trial that gets a green light at 70% efficacy.

I understand your Murphy’s law conundrum - If shit can go wrong it most likely will. If it is overwhelming I’m out. That’s what I don’t get about you- why do you stay in with such little hope. IMO the Pro-140 glass is half full at the very least.
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