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biomaven0

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biomaven0

Re: mcbio post# 215287

Saturday, 11/18/2017 5:15:04 PM

Saturday, November 18, 2017 5:15:04 PM

Post# of 251468
>>Are RIP1 and RIPK1 one and the same?

Yes.

Necroptosis is an alternative cell death pathway different from the more familiar caspase-dependent apoptosis. It involves three kinases - RIPK1, MLKL and RIPK3 of which RIPK1 appears easiest to target. GSK has a RIPK1 compound in trials in IBD, so it has potential applications outside the CNS.

Peter
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