Anavex Life Sciences Corp (AVXL)

[F1ash]

DD overload.

I chose quotes I found relevant. Your results may differ. There are massive amounts of further information contained within the links I included. It’s a good read for those so inclined. I read ~80% of this and don’t even own a share of Anavex (long or short), so those of you who have large amounts of money here should definitely consider reading these imho.


“A recent series of papers described building a model of the sigma-1 receptor and mapping its active site by in silico methods and site-directed mutagenesis [51,52]. The initial model was constructed by homology modeling (PDB 3CIA, 1I24, 2Z2Z, 2Q8I), while its non-homologous part (the N-terminal segment) was constructed de novo. The computer simulation results are in good agreement with the currently available experimental data, and the model itself has been used to design and develop new, more specific synthetic ligands of the sigma-1 receptor [53,54].”

“Given the broad opportunities for using the sigma-1 receptor as a protein-based therapeutic target, the Laboratory of Molecular Neurodegeneration (LMN) of the Peter the Great St. Petersburg Polytechnic University is conducting comprehensive biophysical studies on the role of the sigma-1 receptor in the context of neuropathological research, using such methods as computer modeling, X-ray crystallography, and confocal microscopy.”

http://www.sciencedirect.com/science/article/pii/S2405722316300214


“Various studies have demonstrated that the Sig-1R is involved in maintaining cellular homeostasis and neuronal plasticity in the brain under physiological conditions and protecting the brain against cell loss due to injury or disease. Understanding the sig- nalling cascades regulated by the Sig-1R in acute or delayed neu- rodegeneration as well as in neuronal plasticity will aid the development of new pharmacological means to improve lost neurological function in acute brain injuries and neurodegenerative disorders.”

http://www.sciencedirect.com/science/article/pii/S134786131400019X


“By numerous animal studies, these actions of the sigma-1 receptors have been linked to the pathophysiology of certain human diseases such as depression, ischemia, drug abuse, pain, and cancer. Considering the current pharmacotherapy of neuropsychiatric diseases that largely depends on drugs developed based on the monoamine theory, the sigma-1 receptor is expected to serve as a molecule, which provides a novel target of “post-monoamine” drugs, thus bringing a new approach for treatment of patients suffering from neuropsychiatric diseases.”

“Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer. “

http://www.sciencedirect.com/science/article/pii/S134786131400022X

“Some antidepressants have the properties of the sigma-1 receptor ligands, modulating many neurotransmitter systems, which involves the antidepressant effect associated with the sigma-1 receptor. Indeed, the sigma-1 receptor agonists exhibit a significant antidepressant effect in various models [60]. “

“Additionally, by adjusting the levels of reactive oxygen species, the sigma-1 receptor controls the levels of Rac GTPase in the plasma membrane, thus responsible for the formation of spines in the hippocampus, which is a central brain region responsible for memory formation . Through regulating the level of reactive oxygen species the sigma-1 receptor also activates NF-?B transcription factor, which controls the expression of the Bcl-2 anti-apoptotic protein [7], and is therefore involved in supporting neuronal life. It was demonstrated on cortical cell cultures that SA4503, a sigma-1 receptor agonist, increased the number of surviving cells following oxidative stress through the suppression of the MAP kinase pathway and the expression of glutamate receptors [12].”

“Furthermore, recent studies have revealed the role of impaired calcium signaling in the pathogenesis of Alzheimer's and Huntington's diseases. In particular, changes in calcium homeostasis in the ER result in the disruption of synaptic connections in neurons [69]. The sigma-1 receptor is assumed to act as a sensor of normal calcium homeostasis. “

http://www.sciencedirect.com/science/article/pii/S2405722316300214