Could Missling be using Part C as his secret (early) Phase 3 by taking Ariana feedback and confirming Ariana projections on the "current 32?"
ie. at a minimum, he should be able to escalate dosage on the "ongoing 25" to 50mg in case they were below it and didn't optimally respond, to then determine if observed effect matches Ariana's projections.
ie. on top of the "ongoing 25", Missling has the discretion to use Ariana's screening to pick his "new 7" and confirm if ALL of them "super-respond."
He will have almost 12 months of observations on them by now.