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staccani

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staccani

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Sunday, 06/11/2017 8:22:43 AM

Sunday, June 11, 2017 8:22:43 AM

Post# of 639
Indoximod vs Epacadostat
The main difference between the two is that Indoximod is mainly a IDO2 inhibitor, Epadostat a IDO1 inhibitor (like BMS's). Melanoma shows both IDO1 and IDO2 overexpression, whereas Pancreatic Cancer and AML have a significant IDO2 overexpression. IDO2 overxpression is high in some tumor types, for which Indoximod will have no or little competition: two of them are Pancreatic Cancer and AML, but
also gastric and colon cancers

http://www.sciencedirect.com/science/article/pii/S2452336417300201

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176891/

http://www.bloodjournal.org/content/126/23/1191?sso-checked=true
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