i appreciate your weighing in and adding color. i would imagine a good MD would discuss these risks and a well informed pt can then decide along w their doc the best first line drug. At 1/500,000 the risks are probably comparable to dying in a plane crash so really a no brainer IMO if you were otherwise predisposed to taking the drug for other reasons efficacy other SE profile and so forth. That said my impression is that not every doc gives pts this kind of granularity and autonomy to contribute to decision making (as they should), so it might still sway some prescribing patterns. Time will tell.
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