Anavex Life Sciences Corp (AVXL)

[OFP]

The following comes from the reference YOU supplied by Hayashi and Su:

Overexpression of
Sig-1R-EYFP (Figure 5E) or wild-type Sig-1Rs (data not
shown), however, suppressed ER stress-induced activa-
tion of sensor proteins PERK and ATF6 (Figure 5E). It is
unclear at present why Sig-1R overexpression did not af-
fect the activation of IRE1. Nevertheless, because ER
stress longer than 30 min can cause the redistribution of
Sig-1Rs to the entire ER (Figure 5D), it is possible that re-
distributed Sig-1Rs may play a role in the suppression of
misfolded proteins that cause UPR.
Inasmuch as Sig-1Rs can suppress UPR, we tested
whether dysfunction of Sig-1Rs might affect cell death/
survival. Results showed that knocking down of Sig-1Rs
significantly enhances apoptotic cell death induced by ei-
ther TG or glucose deprivation (Figure 5F).
Taken together, the above data confirm the chaperone
nature of Sig-1Rs at the ER.