Powerball numbers for 04/22/2017 are: 21 39 41 48 63 Powerball 6 Powerplay 3X The estimated Grand Prize was $90,000,000 ($56,300,000 cash). There was no Grand Prize Winner. The next Powerball drawing will be on Wednesday, April 26th, 2017 with an estimated Grand Prize of $100,000,000 ($62,500,000 cash). http://www.powerball.com/pb_home.asp