Thursday, April 20, 2017 9:11:30 AM
Abstract #1864: Feasibility of magnetic relaxometry for early ovarian cancer detection: Preliminary evaluation of sensitivity and specificity in cell culture and in mice Kelsey B. Mathieu, Zhen Lu, Hailing Yang, Lan Pang, Adam Kulp, John D. Hazle, Robert C. Bast, Jr.
The University of Texas MD Anderson Cancer Center, Houston, TX
Conclusion
MRX appears sufficiently sensitive to detect clusters of 1 million cells in culture or 10 million cells in mice with a high level of specificity.
Sensitivity may be improved using nanoparticles coated with antibodies against antigens that are overexpressed by a larger fraction of ovarian
cancers and will be the focus of future work. Efforts towards such evaluation have already begun with the conjugation of anti-CA125
antibodies to SPIONS and verification of binding to ovarian cancer cells through flow cytometry.
Our next step will be to perform MRX studies evaluating sensitivity and specificity of the anti-CA125 SPIONS in cell culture and in mice.
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