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In an attempt to get from point A to point B ie connecting the dots. What is the history of Takeda Pharmaceutical in the Heart field?

I found an article from June 15, 2015 where Takeda announced a collaboration with Sanford-Burnham to develop a drug at a Orlando facility
The deal was for 2 years and we are near that deadline now. I don't see any progress. In fact there is noise that Sanford-Burnham hasn't hired enough people in which the State had given them funds.

http://www.orlandosentinel.com/health/os-sanford-burnham-takeda-heart-failure-20150614-story.html

Local scientists are embarking on a research project in hopes of finding a new drug for treating heart failure.

Sanford-Burnham Medical Research Institute at Lake Nona has a struck a two-year partnership with Japanese pharmaceutical giant Takeda to explore new ways of slowing down and possibly reversing the disease.

"This partnership is focused on earlier processes of developing heart failure, before part of the heart is dead," said Dr. Daniel Kelly, scientific director at Sanford-Burnham. "And part of our interest relates to focusing on metabolism and the way the heart is able to produce energy from nutrients."

Financial terms of the partnership were not released.

Heart failure affects more than 5 million Americans, according to the Centers for Disease Control and Prevention. Nearly half of those with heart failure die within five years of diagnosis.

There's no cure for a failing heart. Current medications control heart rhythm, fluid intake or blood pressure. Surgery and implantable devices also are options for advance stages of the disease.

But Sanford-Burnham researchers have their eyes on a different pathway.

"The failing heart becomes an energy-starved heart, and we think we have ways to reverse that so the heart can continue to make and use its energy even as it's failing and becoming inefficient," Kelly said. "We want to reinvigorate the heart so it can start using its fuel again and stop this vicious cycle that leads to energy starvation and heart failure."

The new research project is years away before an actual drug. Basic scientists first find a biological pathway and proteins that are involved a disease process like heart failure. They try to find out how these proteins are disrupted, turned on or turned off.

They test hundreds of thousands of chemicals on those target proteins to see which ones have a specific and desired effect. They then develop those chemicals to stable compounds that could be used a drug, before running animal tests and human trials.

"This is one of the more exciting ones for me, one, because I'm a cardiologist and it's square in middle of heart disease, and the second exciting part is that it's a little closer to drug discovery this time," Kelly said.

While Dr. Kelly's team focuses in the biological research part of the collaboration, renowned structural biologist Fraydoon Rastinejad visualizes the proteins in three-dimensional models to explore their shapes, their atoms and their potential for accepting a drug.

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Sanford Burnham institute's Dr. Daniel Kelly to leave for UPenn job
Mar 10, 2017,
Lake Nona's Sanford Burnham Prebys Medical Discovery Institute announced it will bid farewell to one of top researchers — but a plan is in place to find a replacement.
http://www.bizjournals.com/orlando/news/2017/03/10/sanford-burnham-institutes-daniel-kelly-to-lead.html
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Sanford Burnham scientists worry about their future
November 1, 2016
http://www.orlandosentinel.com/health/os-sanford-burnham-faculty-20161101-story.html

As the state pushes to reclaim half of the $150 million it invested to lure Sanford Burnham to Orlando, one of the research institute's most prized assets — its intellectual talent pool — remains in flux.
......
Since May, when the institute's Lake Nona researchers learned that the La Jolla, Calif., leadership is looking for a strategy to leave Florida without their knowledge, tensions have been mounting.

Fifteen members of the faculty signed a letter in May, expressing their lack of confidence in the institute's leadership.