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Clinical Trial Data from Clinicaltrials.gov using search term low+dose+naltrexone
Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory ArthritisConditions: Osteoarthritis; Arthritis, Rheumatoid; Arthritis, Psoriatic
Interventions: Drug: Naltrexone; Drug: Placebo
Sponsor: VA Office of Research and Development
Not yet recruiting - verified December 2016
Immune Effects of Low-dose Naltrexone in ME/CFSCondition: Fatigue Syndrome, Chronic
Intervention: Drug: Naltrexone HCl
Sponsor: University of Alabama at Birmingham
Suspended - verified March 2017
Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism?Condition: Fibromyalgia
Interventions: Drug: Low dose naltrexone; Drug: Placebo
Sponsor: Rigshospitalet, Denmark
Recruiting - verified August 2016
Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Prior to First Dose of VIVITROL® (Naltrexone for Extended-Release Injectable Suspension)Condition: Opioid Use Disorder
Interventions: Drug: NTX/BUP; Drug: NTX/PBO-B; Drug: PBO-N/PBO-B
Sponsor: Alkermes, Inc.
Completed - verified February 2017
Low-Dose Naltrexone for the Treatment of Complex Regional Pain SyndromeCondition: Complex Regional Pain Syndrome
Interventions: Drug: LDN; Drug: Placebo
Sponsor: Stanford University
Recruiting - verified April 2016
Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed UseCondition: Alcohol Dependence
Intervention: Drug: nalmefene
Sponsor: H. Lundbeck A/S
Completed - verified December 2016
Low Dose Naltrexone (LDN) Immune MonitoringCondition: Fibromyalgia
Interventions: Drug: Low Dose Naltrexone; Drug: Placebo
Sponsor: Stanford University
Unknown status - verified April 2014
Neuropsychoanalytic Treatment of Failed Back Surgery Syndrome-Opioid DependenceCondition: Pain
Intervention: Behavioral: Neuropsychoanalytic therapy
Sponsors: State University of New York - Upstate Medical University; University at Buffalo
Completed - verified January 2015
Low-Dose Naltrexone (LDN) for Depression Relapse and RecurrenceConditions: Major Depressive Disorder; Depression, Unipolar; Recurrence; Relapse
Interventions: Drug: Naltrexone; Drug: Placebo
Sponsors: Massachusetts General Hospital; Boston Clinical Trials (BCT)
Completed - verified January 2017
Low Dose Naltrexone in Symptomatic Inflammatory Bowel DiseaseConditions: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis
Interventions: Drug: Low dose naltrexone; Drug: Placebo
Sponsor: Santa Barbara Cottage Hospital
Withdrawn - verified November 2014
Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese SubjectsConditions: Obesity; Overweight
Interventions: Drug: NB; Behavioral: CLI; Behavioral: Usual Care
Sponsor: Orexigen Therapeutics, Inc
Completed - verified November 2015
Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid DependenceCondition: Opiate Dependence
Interventions: Drug: very low dose naltrexone; Drug: extended release naltrexone; Drug: buprenorphine/naloxone
Sponsors: Paolo Mannelli; Alkermes, Inc.
Completed - verified April 2016
Low Dose Naltrexone for Metastatic Melanoma, Castrate Resistant Prostate Cancer and Renal CancerConditions: Melanoma; Prostate Cancer; Renal Cancer
Intervention: Drug: Naltrexone
Sponsor: Maria Constantinou
Terminated - verified July 2015
A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back PainConditions: Chronic Pain; Low Back Pain; Analgesia
Interventions: Drug: ALO-02; Drug: Placebo
Sponsor: Pfizer
Completed - verified August 2014
Effect of Naltrexone on Counterregulatory Mechanisms in HypoglycemiaCondition: Hypoglycemia
Interventions: Drug: Naltrexone High Dose; Drug: Naltrexone Low Dose
Sponsors: Yale University; National Institutes of Health (NIH)
Completed - verified February 2016
Low Dose Naltrexone for Glioma PatientsCondition: Malignant Glioma
Interventions: Drug: LDN; Drug: Placebo
Sponsor: Katy Peters
Completed - verified June 2015
N-acetylcysteine Plus Naltrexone for the Treatment of Alcohol DependenceCondition: Alcoholism
Interventions: Drug: N-acetylcysteine + high-dose naltrexone (150 mg); Drug: High-dose naltrexone (150 mg) alone; Drug: Low-dose naltrexone (50 mg) alone
Sponsor: VA Office of Research and Development
Completed - verified February 2017
Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+Condition: HIV Seropositivity
Interventions: Other: ARV's + Placebo; Drug: Naltrexone; Drug: Naltrexone + ARV's
Sponsor: The Ojai Foundation
Completed - verified August 2010
Conversion to Embeda With Rescue TrialConditions: Chronic Disease; Pain
Intervention: Drug: morphine sulfate and naltrexone hydrochloride (EMBEDA)
Sponsor: Pfizer
Terminated - verified October 2012
Naltrexone and Hypoglycemia in Type 1 DiabetesConditions: Type 1 Diabetes; Hypoglycemia Unawareness
Interventions: Drug: Naltrexone; Drug: Naltrexone
Sponsors: University of Minnesota - Clinical and Translational Science Institute; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); American Diabetes Association
Completed - verified June 2016
Low Dose Naltrexone for the Treatment of Juvenile Primary Fibromyalgia SyndromeCondition: Fibromyalgia
Intervention: Drug: Low Dose Naltrexone
Sponsor: Stanford University
Withdrawn - verified December 2015
Pilot Trial of Naltrexone for Obesity in Women With SchizophreniaConditions: Obesity; Schizophrenia; Schizoaffective Disorder
Interventions: Drug: Naltrexone 25mg; Other: Placebo
Sponsors: Yale University; Ethel F. Donaghue Women's Health Investigator Program at Yale
Completed - verified August 2016
The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking LapseCondition: Smoking
Interventions: Drug: naltrexone; Drug: varenicline; Drug: placebo
Sponsors: Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed - verified November 2016
Effects of Low-dose Naltrexone in Combination With a Range of Smoked MarijuanaCondition: Marijuana Smoking
Interventions: Drug: Naltrexone; Drug: marijuana
Sponsors: New York State Psychiatric Institute; Research Foundation for Mental Hygiene, Inc.; National Institute on Drug Abuse (NIDA)
Completed - verified October 2016
Study to Evaluate the Subjective Effects of PTI-801 in Non-Physically Dependent Subjects With a History of Drug AbuseCondition: Opioid-Related Disorders
Intervention: Drug: oxycodone and naltrexone
Sponsor: Pain Therapeutics
Completed - verified March 2016
The Efficacy of Low Dose Naltrexone Therapy in Children With Crohn's DiseaseCondition: Crohn's Disease
Interventions: Drug: Naltrexone; Other: Placebo, sugar pill
Sponsor: Penn State University
Completed - verified May 2013
The Effects of Naltrexone on Ac
tive Crohn's DiseaseConditions: Inflammation; Crohn's Disease
Interventions: Drug: Naltrexone-HCl; Drug: Placebo
Sponsors: Penn State University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); The Broad Foundation
Completed - verified May 2013
Effects of Low Dose Naltrexone in FibromyalgiaConditions: Fibromyalgia; Persian Gulf Syndrome
Interventions: Drug: Low Dose Naltrexone; Drug: Placebo - sugar pill
Sponsors: Stanford University; American Fibromyalgia Syndrome Association
Completed - verified September 2015
Naltrexone for Heavy Drinking in Young AdultsConditions: Alcohol Consumption; Alcoholic Intoxication; Alcoholism; Alcohol-induced Disorders
Interventions: Behavioral: BASICS counseling; Drug: naltrexone; Drug: placebo naltrexone
Sponsors: Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed - verified July 2014
A Randomized Placebo-Controlled, Crossover-Design Study of the Effects of Low Dose NaltrexoneCondition: Multiple Sclerosis
Interventions: Drug: 4.5 mg Naltrexone; Drug: Naltrexone
Sponsor: University of California, San Francisco
Completed - verified February 2007
Effects of a Range of Naltrexone Doses in Combination With Smoked MarijuanaCondition: Marijuana Smoking
Interventions: Drug: Naltrexone; Drug: Marijuana
Sponsors: New York State Psychiatric Institute; Research Foundation for Mental Hygiene, Inc.; National Institute on Drug Abuse (NIDA)
Completed - verified October 2016
Trial of Low-Dose Naltrexone for Children With Pervasive Developmental Disorder (PDD)Condition: Pervasive Developmental Disorder
Intervention: Drug: low dose naltrexone
Sponsors: Hadassah Medical Organization; Jerusalem Institute for Child Development
Unknown status - verified April 2006
Addition of Naltrexone to Methadone TaperConditions: Heroin Dependence; Opioid-Related Disorders; Substance-Related Disorders
Interventions: Drug: Naltrexone; Drug: Placebo comparator; Drug: naltrexone; Drug: naltrexone
Sponsor: National Institute on Drug Abuse (NIDA)
Completed - verified August 2008
Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight GainConditions: Smoking; Nicotine Dependence
Interventions: Drug: Naltrexone; Drug: Bupropion
Sponsors: Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed - verified January 2013
Targeted Interventions for Weight-Concerned SmokersCondition: Nicotine Dependence
Interventions: Drug: Naltrexone; Drug: Transdermal nicotine replacement; Behavioral: Behavioral counseling
Sponsors: Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed - verified January 2013
Rapid Opiate Detoxification and Naltrexone Induction Using Buprenorphine - 2Condition: Opioid-Related Disorders
Intervention: Drug: Buprenorphine
Sponsors: University of California, Los Angeles; National Institute on Drug Abuse (NIDA)
Completed - verified January 2016
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