NorthWest Biotherapeutics Inc (NWBO)

[Barunuuk]

AVII

"The median OS of the group of 51 Information Arm patients as a whole is 18.3 months. About 30% of the patients (15 of the 51) lived beyond 2 years, and most of these patients (12 of the 15) remain alive. "

excerpt from news release, linked below: (so not 14 months)

http://www.prnewswire.com/news-releases/nw-bio-reports-promising-survival-data-in-51-gbm-patients-treated-with-dcvax-l-300056928.html

Using the information above we know

25 patients had OS < 18 months and 26 > 18 months. We also know 16 of the 25 indeterminates lived more than 21 months, and 3 others lived 30.1 months. And since 26 of the overall 51 lived more than 18 months, that leaves 7 patients that lived between 18 and 21 months. So depending on where these OS were, there could be minimal effect to the median value as the rest of the 37 patients all offset one another on each side of 21 months. Again, I don't believe that including these would have dropped the ICT-107 OS results drastically, we are talking about 7 patients between 2-3 months, therefore the median would be 20 instead of 21 months, or so. Therefore one could suggest ICT-107 mOS could have been 22 months instead of 21 months, but also could have had more pseudoprogressions and should have been 19 months. Again, as I said, I do not believe including them would effect the median value as much, but could effect the tail.