Algernon Pharmaceuticals Inc (AGNPF)

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PITTCON CONFERENCE & EXPO 2017 McCormick Place Chicago, IL, USA





ABSTRACT

Basic Information

Abstract Number: 2440 - 7
Author Name: Michael T Costanzo - Breathtec Biomedical
Session Title: Metabolomics: Breath as a Sample for Clinical Analysis
Event Type: Symposia
Event Title: Towards Point-of-Care Diagnostic Screening for Breath Analysis Using FAIMS and FAIMS/MS

Presider Name: Richard A Yost Co-Author: Michael S Wei, Jared J Boock, Richard A Yost
Affiliation: University of Florida Affiliation: University of Florida, Cannabix Technologies Inc.

Date: Thursday, March 9, 2017
Start Time: 04:10 PM (Slot #7)
Location: W179b

Abstract Content

Since its inception, field asymmetric ion mobility spectrometry (FAIMS) has been envisioned as a field-portable device, as it affords less expense and greater simplicity than many similar methods. Portable FAIMS could provide in situ analysis, allowing researchers to bring the lab to the sample. Ideally, these are simple, robust devices that may be operated by non-professional personnel, yet still provide adequate data when in the field. While reducing the size and complexity tends to bring with it a loss of performance and accuracy, this is made up for by the incredibly high throughput and overall portability of the instrument. Moreover, the point-of-care (POC) FAIMS device can be brought back to the lab and coupled to a conventional mass spectrometer to provide the necessary method development and compound validation. However, to realize such a device, several considerations for miniaturization of the instrumentation must be discussed, as well as how the future of various applications may benefit from the development and acceptance of POC FAIMS.

In preliminary studies, numerous standards were analyzed by both home-built and commercially available FAIMS systems. Several components necessary for a miniaturized POC FAIMS device are currently under development; notably, a novel asymmetric square-waveform generator that is responsible for separation of ions by FAIMS, and a standalone detector which allows the FAIMS device to operate without the need for a mass spectrometer. These components were tested for function, efficiency, and reliability, and the data will be presented here.

ca.pittcon.org/Technical%20Program/tpabstra17.nsf/focus/13EB647AAA156C048525800B006D8D56?opendocument&nav=keyword&cat=Biomedical


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