Allergan Plc (AGN)

[north40000]

Further discussion of Dry Eye Syndrome[DES]:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127432/pdf/opth-10-2337.pdf


Eicosapentaenoic acid (EPA), docosahexaenoic acid
(DHA), and alpha linolenic acid (ALA) are the three omega-3
fatty acids that cannot be synthesized in the body and
have to be supplemented in diet. EPA and DHA modulate
prostaglandin metabolism toward anti-inflammatory
prostaglandin synthesis due to competitive inhibition of
the arachidonic acid pathway.48 Omega-3 supplementation
demonstrates an anti-inflammatory effect, inhibiting creation
of omega-6 prostaglandin precursors, preventing apoptosis
of the secretory epithelial cells in the lacrimal gland, and
clearing meibomitis, which allows for a healthier lipid layer
to protect the tear film and cornea.49
Therapeutic responses from topical anti-inflammatory
agents do not result in significant clinical improvement in
more than half the patients treated.35,50 This is evidenced by
moderate, or complete, regression of symptoms in only 43%,
or 57%, respectively, of dry eye patients with delayed clearance
following treatment with loteprednol.51 Similarly, treatment
with topical cyclosporine 0.1% for 6 months showed
only moderate response to treatment in 39% of symptomatic
dry eye patients.50....{more]